(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) 

(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) is a CRF antagonist. (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) prevents the IL-1a induced Luteinizing hormone (LH) inhibition^[1].

3553.12

C₁₅₉H₂₆₇N₄₉O₄₃

150646-45-0

{d-Phe}-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-{Nle}-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-{Leu(α-Me)}-{Nle}-Glu-Ile-Ile-NH2

{d-Phe}-HLLREVLE-{Nle}-ARAEQLAQQAHSNRK-{Leu(α-Me)}-{Nle}-EII-NH2

CC[C@H](C)[C@@H](C(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC([C@H](CCCC)NC([C@@](CC(C)C)(C)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CC1=CN=CN1)NC([C@H](C)NC([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CCCC)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](N)CC2=CC=CC=C2)=O)CC3=CN=CN3)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Feng YJ, et al. An inhibitory effects of interleukin-1a on basal gonadotropin release in the ovariectomized rhesus monkey: reversal by a corticotropin-releasing factor antagonist. Endocrinology. 1991 Apr;128(4):2077-82.  [Content Brief]