2. Immunology/Inflammation Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. TROP2 Antibody-Drug Conjugates (ADCs) Topoisomerase
  4. Datopotamab deruxtecan

Datopotamab deruxtecan  (Synonyms: DS-1062; Dato-DXd)

Cat. No.: HY-141598 Purity: 99.54%
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Datopotamab deruxtecan (DS-1062; Dato-DXd) is a trophoblast cell surface antigen 2 (TROP2)-directed antibody-drug conjugate (ADC). Datopotamab deruxtecan has a potent antitumor activity.

For research use only. We do not sell to patients.

Datopotamab deruxtecan Chemical Structure

Datopotamab deruxtecan Chemical Structure

CAS No. : 2238831-60-0

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5 mg USD 3800 In-stock
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Based on 1 publication(s) in Google Scholar

Datopotamab deruxtecan Related Antibodies

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Description

Datopotamab deruxtecan (DS-1062; Dato-DXd) is a trophoblast cell surface antigen 2 (TROP2)-directed antibody-drug conjugate (ADC). Datopotamab deruxtecan has a potent antitumor activity[1].

IC50 & Target[1]

Topoisomerase I

 

In Vitro

Datopotamab deruxtecan (Dato-DXd; 100 μg/mL) binds specifically to TROP2 and was internalized into tumor cells followed by intracellular trafficking to lysosome and Deruxtecan release, which induced DNA damage and apoptosis in TROP2-expressing tumor cells in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Datopotamab deruxtecan Related Antibodies
In Vivo

Datopotamab deruxtecan (Dato-DXd; 6 mg/kg) shows potent antitumor activity with tumor regression in several TROP2-expressing xenograft tumors including NSCLC patient-derived xenograft (PDX) models. Safety profiles of Datopotamab deruxtecan in rats and cynomolgus monkeys are acceptable[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

149000 (average)

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Datopotamab deruxtecan]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.54%

COA (231 KB) RP-HPLC (197 KB) Others (187 KB)

Handling Instructions (2659 KB)
References
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Datopotamab deruxtecan Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Datopotamab deruxtecan2238831-60-0DS-1062 Dato-DXdDS1062DS 1062TROP2Antibody-Drug Conjugates (ADCs)TopoisomeraseEGP-1M1S1GA733-1Antibody-Drug ConjugatesADCantitumorDeruxtecan,Inhibitorinhibitorinhibit

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