2. NF-κB
  3. Keap1-Nrf2
  4. Dimethyl fumarate-d6

Dimethyl fumarate-d6 is a deuterium labeled Dimethyl fumarate. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression[1][2][3][4][5][6].

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Dimethyl fumarate-d<sub>6</sub> Chemical Structure

Dimethyl fumarate-d6 Chemical Structure

CAS No. : 66487-95-4

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1 mg USD 150 In-stock
5 mg USD 380 In-stock
10 mg USD 640 In-stock
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Based on 1 publication(s) in Google Scholar

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Dimethyl fumarate-d6 Related Antibodies

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Description

Dimethyl fumarate-d6 is a deuterium labeled Dimethyl fumarate. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression[1][2][3][4][5][6].

Molecular Weight

150.16

Formula

C6H2D6O4
CAS No.
Unlabeled Cas

624-49-7
Appearance

Solid

Color

White to off-white

SMILES

O=C(OC([2H])([2H])[2H])/C=C/C(OC([2H])([2H])[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : ≥ 10 mg/mL (66.60 mM)

DMSO : ≥ 5 mg/mL (33.30 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 2 mg/mL (13.32 mM)

DMF:PBS(pH 7.2)(1:1) : ≥ 0.5 mg/mL (3.33 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.6596 mL 33.2978 mL 66.5956 mL
5 mM 1.3319 mL 6.6596 mL 13.3191 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.49%

COA (246 KB) HNMR (200 KB) RP-HPLC (193 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF:PBS(pH 7.2)(1:1) / Ethanol / DMSO / DMF 1 mM 6.6596 mL 33.2978 mL 66.5956 mL 166.4891 mL
Ethanol / DMSO / DMF 5 mM 1.3319 mL 6.6596 mL 13.3191 mL 33.2978 mL
10 mM 0.6660 mL 3.3298 mL 6.6596 mL 16.6489 mL
DMSO / DMF 15 mM 0.4440 mL 2.2199 mL 4.4397 mL 11.0993 mL
20 mM 0.3330 mL 1.6649 mL 3.3298 mL 8.3245 mL
25 mM 0.2664 mL 1.3319 mL 2.6638 mL 6.6596 mL
30 mM 0.2220 mL 1.1099 mL 2.2199 mL 5.5496 mL
DMF 40 mM 0.1665 mL 0.8324 mL 1.6649 mL 4.1622 mL
50 mM 0.1332 mL 0.6660 mL 1.3319 mL 3.3298 mL
60 mM 0.1110 mL 0.5550 mL 1.1099 mL 2.7748 mL
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Dimethyl fumarate-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethyl fumarate-d666487-95-4Keap1-Nrf2Inhibitorinhibitorinhibit

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