2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. Enzalutamide-d6

Enzalutamide-d6  (Synonyms: MDV3100-d6)

Cat. No.: HY-70002S1 Purity: 99.74%
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Enzalutamide-d6 is a deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells[1].

For research use only. We do not sell to patients.

Enzalutamide-d<sub>6</sub> Chemical Structure

Enzalutamide-d6 Chemical Structure

CAS No. : 1443331-94-9

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1 mg USD 180 In-stock
5 mg USD 750 In-stock
10 mg USD 1350 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Enzalutamide-d6:

Enzalutamide-d6 Related Antibodies

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Description

Enzalutamide-d6 is a deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells[1].

Molecular Weight

470.47

Formula

C21H10D6F4N4O2S
CAS No.
Unlabeled CAS

915087-33-1
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC)C1=CC=C(N(C(N2C3=CC=C(C#N)C(C(F)(F)F)=C3)=S)C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C2=O)C=C1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMF : ≥ 25 mg/mL (53.14 mM)

DMSO : ≥ 20 mg/mL (42.51 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 0.5 mg/mL (1.06 mM)

DMF:PBS (pH 7.2) (1:4) : ≥ 0.2 mg/mL (0.43 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1255 mL 10.6277 mL 21.2553 mL
5 mM 0.4251 mL 2.1255 mL 4.2511 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO / DMF 1 mM 2.1255 mL 10.6277 mL 21.2553 mL 53.1384 mL
DMSO / DMF 5 mM 0.4251 mL 2.1255 mL 4.2511 mL 10.6277 mL
10 mM 0.2126 mL 1.0628 mL 2.1255 mL 5.3138 mL
15 mM 0.1417 mL 0.7085 mL 1.4170 mL 3.5426 mL
20 mM 0.1063 mL 0.5314 mL 1.0628 mL 2.6569 mL
25 mM 0.0850 mL 0.4251 mL 0.8502 mL 2.1255 mL
30 mM 0.0709 mL 0.3543 mL 0.7085 mL 1.7713 mL
40 mM 0.0531 mL 0.2657 mL 0.5314 mL 1.3285 mL
DMF 50 mM 0.0425 mL 0.2126 mL 0.4251 mL 1.0628 mL
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Enzalutamide-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enzalutamide-d61443331-94-9MDV3100-d6Androgen ReceptordeuteriumcancerLNCaPprostatecellsInhibitorinhibitorinhibit

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