ER degrader 4

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ER degrader 4 is a selective and orally active estrogen receptor degrader. ER degrader 4 has anti-tumor activity.

For research use only. We do not sell to patients.

ER degrader 4 Chemical Structure

CAS No. : 2913192-39-7

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Description

ER degrader 4 is a selective and orally active estrogen receptor degrader. ER degrader 4 has anti-tumor activity^[1].

In Vitro

ER degrader 4 (Compound 22h) inhibits MCF-7 cell proliferation with an IC₅₀ of 0.20 μM^[1].
ER degrader 4 (1 nM-10 μM, 24 h) degrades ER in MCF-7 cells dose-dependently^[1].
ER degrader 4 (10 μM, 24 h) decreases the gene expression levels of GREB1, PGR, and TFF1 in MCF-7 cells^[1].
ER degrader 4 (10 μM, 24 h) arrests MCF-7 cells in G0/G1 phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[7]

Cell Line:	MCF-7 cell
Concentration:	1 nM, 100 nM, 1 μM and 10 μM
Incubation Time:	24 h
Result:	Degraded ER dose-dependently, shows maximum degradation at 10 μM.

In Vivo

ER degrader 4 (Compound 22h) (30 mg/kg, oral gavage) inhibits tumor growth in a MCF-7 xenograft model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MCF-7 xenograft model^[3]
Dosage:	30 mg/kg
Administration:	Oral gavage
Result:	Significantly inhibited tumor growth with no significant body weight loss. Reduces protein level of Ki67, ER, and PR in resected xenograft tumors.

Molecular Weight

446.49

Formula

C₂₆H₁₉FO₄S

CAS No.

2913192-39-7

Unlabeled Cas

SMILES

O=C(C1=C(C=C(C=C1)C)C)C(SC2=CC(F)=CC=C23)=C3OC4=CC=C(C=C4)/C=C/C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xie YQ, et al. Design, synthesis and structure-activity relationship of novel oxime ether strobilurin derivatives containing substituted benzofurans. Pest Manag Sci. 2015 Mar;71(3):404-14. [Content Brief]

ER degrader 4 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ER degrader 42913192-39-7ER degrader4ER degrader-4Estrogen Receptor/ERRCancerMCF-7tumorInhibitorinhibitorinhibit

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