1. Metabolic Enzyme/Protease Anti-infection Cytoskeleton Cell Cycle/DNA Damage
  2. HIF/HIF Prolyl-Hydroxylase Parasite Microtubule/Tubulin Antibiotic
  3. Fenbendazole-d3

Fenbendazole-d3 is a deuterium labeled Fenbendazole. Fenbendazole-d3 is a HIF-1α agonist and activates the HIF-1α-related GLUT1 pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53[1][2][3][4].

For research use only. We do not sell to patients.

Fenbendazole-d<sub>3</sub> Chemical Structure

Fenbendazole-d3 Chemical Structure

CAS No. : 1228182-47-5

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Based on 2 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Fenbendazole-d3 is a deuterium labeled Fenbendazole. Fenbendazole-d3 is a HIF-1α agonist and activates the HIF-1α-related GLUT1 pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53[1][2][3][4].

In Vitro

Fenbendazole-d3 (20 µM; for 48 h) reverses the inhibiting influence exerted by miR-143-5p on proliferation, colony-forming capacity, and migration[1].
Fenbendazole-d3 (10 µM; for 48 h) elevates the protein expression levels of HIF-1α and GLUT1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: BT-549 and MCF-7 cells
Concentration: 20 µM
Incubation Time: For 48 h
Result: Reversed the inhibiting influence exerted by miR-143-5p on proliferation, colony-forming capacity, and migration.

Western Blot Analysis[1]

Cell Line: BT-549 and MCF-7 cells
Concentration: 10 µM
Incubation Time: For 48 h
Result: Elevated the protein expression levels of HIF-1α and GLUT1.
Molecular Weight

302.37

Formula

C15H10D3N3O2S

CAS No.
Unlabeled CAS

43210-67-9

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(OC([2H])([2H])[2H])NC1=NC2=CC=C(SC3=CC=CC=C3)C=C2N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (16.54 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 5 mg/mL (16.54 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3072 mL 16.5360 mL 33.0721 mL
5 mM 0.6614 mL 3.3072 mL 6.6144 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.46%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 3.3072 mL 16.5360 mL 33.0721 mL 82.6802 mL
5 mM 0.6614 mL 3.3072 mL 6.6144 mL 16.5360 mL
10 mM 0.3307 mL 1.6536 mL 3.3072 mL 8.2680 mL
15 mM 0.2205 mL 1.1024 mL 2.2048 mL 5.5120 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Fenbendazole-d3
Cat. No.:
HY-B0413S
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