2. GPCR/G Protein
  3. GnRH Receptor
  4. Fsh receptor-binding inhibitor fragment(bi-10)

Fsh receptor-binding inhibitor fragment(bi-10) 

Cat. No.: HY-P4190 Purity: 99.61%
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FSH receptor-binding inhibitor fragment(bi-10) is a potent FSH antagonist. FSH receptor-binding inhibitor fragment(bi-10) blocks the binding of FSH to FSHR, and alteres FSH action at the receptor level. FSH receptor-binding inhibitor fragment(bi-10) results in the suppression of ovulation and causes follicular atresia of mice. FSH receptor-binding inhibitor fragment(bi-10) has the potential for utilizing to restrain the carcinogenesis of ovarian cancer by down-regulating overexpression of FSHR and ERβ in the ovaries.

For research use only. We do not sell to patients.

Fsh receptor-binding inhibitor fragment(bi-10) Chemical Structure

Fsh receptor-binding inhibitor fragment(bi-10) Chemical Structure

CAS No. : 163973-98-6

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1 mg USD 55 In-stock
5 mg USD 130 In-stock
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Based on 1 publication(s) in Google Scholar

Fsh receptor-binding inhibitor fragment(bi-10) Related Antibodies

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Description

FSH receptor-binding inhibitor fragment(bi-10) is a potent FSH antagonist. FSH receptor-binding inhibitor fragment(bi-10) blocks the binding of FSH to FSHR, and alteres FSH action at the receptor level. FSH receptor-binding inhibitor fragment(bi-10) results in the suppression of ovulation and causes follicular atresia of mice. FSH receptor-binding inhibitor fragment(bi-10) has the potential for utilizing to restrain the carcinogenesis of ovarian cancer by down-regulating overexpression of FSHR and ERβ in the ovaries[1].

In Vivo

FSH receptor-binding inhibitor fragment(bi-10) (10, 20, 30, 40 mg/kg; Intramuscularly injection; once a day for five consecutive days) with high dose (30 mg/kg to 40 mg/kg) can suppress ovarian and follicular development, and attenuate expression levels of ERβ and FSHR mRNAs and proteins in the ovaries, additionally inhibit E2 production[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Prepuberty Kunming female mice of 21-days old and body weight of 22.3±1.52g[1]
Dosage: 10, 20, 30, 40 mg/kg
Administration: Intramuscularly injection; once a day for five consecutive days
Result: Could attenuate FSH promoting effect on the follicular development, resulting in the poor maturation of ovarian follicles.
High dose (40mg/kg) treatment blocked the follicle development of mice.
High dose of FRBI (40mg/kg) treatment blocked the follicle development of mice.
Molecular Weight

1058.06

Formula

C42H67N13O19
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

Sequence

Thr-Glu-Asn-Leu-Glu-Pro-Asn-Gly-Glu-Gly-NH2
Sequence Shortening

TENLEPNGEG-NH2
SMILES

C[C@@H](O)[C@H](N)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CCC(O)=O)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (94.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9451 mL 4.7256 mL 9.4513 mL
5 mM 0.1890 mL 0.9451 mL 1.8903 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9451 mL 4.7256 mL 9.4513 mL 23.6281 mL
5 mM 0.1890 mL 0.9451 mL 1.8903 mL 4.7256 mL
10 mM 0.0945 mL 0.4726 mL 0.9451 mL 2.3628 mL
15 mM 0.0630 mL 0.3150 mL 0.6301 mL 1.5752 mL
20 mM 0.0473 mL 0.2363 mL 0.4726 mL 1.1814 mL
25 mM 0.0378 mL 0.1890 mL 0.3781 mL 0.9451 mL
30 mM 0.0315 mL 0.1575 mL 0.3150 mL 0.7876 mL
40 mM 0.0236 mL 0.1181 mL 0.2363 mL 0.5907 mL
50 mM 0.0189 mL 0.0945 mL 0.1890 mL 0.4726 mL
60 mM 0.0158 mL 0.0788 mL 0.1575 mL 0.3938 mL
80 mM 0.0118 mL 0.0591 mL 0.1181 mL 0.2954 mL
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Fsh receptor-binding inhibitor fragment(bi-10) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fsh receptor-binding inhibitor fragment(bi-10)163973-98-6GnRH ReceptorGonadotropin releasing hormone receptorGNRHRFSHFSHRovulationfollicular atresiacarcinogenesisovarian cancerERβInhibitorinhibitorinhibit

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