1. Immunology/Inflammation Anti-infection
  2. Toll-like Receptor (TLR) Antibiotic
  3. FSL-1

FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.

For research use only. We do not sell to patients.

FSL-1 Chemical Structure

FSL-1 Chemical Structure

CAS No. : 322455-70-9

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Description

FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection[1][2].

IC50 & Target[1][2]

TLR2

 

TLR6

 

In Vitro

FSL-1 significantly reduces HSV-2 replication in vitro. FSL-1 reduces HSV-2 replication in human vaginal epithelial cells (EC)[1].
FSL-1 induces significant resistance to experimental genital HSV-2 infection through elaboration of a specific cytokine response profile[1].
FSL-1 enhances phagocytosis of bacteria by macrophages through a Toll-like receptor 2-mediated signalling pathway[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: V11I, V12I or V19I immortalized human vaginal EC
Concentration: 6 μg or 0.1 μg
Incubation Time: Added at 24, 6 or just prior to HSV-2 inoculation (104pfu/well)
Result: The 6 μg does produced significant reductions when delivered at 24 or 6 h prior to HSV-2 inoculation. The 0.1 μg dose produced reduced HSV-2 replication at 24 or 6 h prior to viral challenge.
Molecular Weight

1666.16

Formula

C84H140N14O18S

CAS No.
Unlabeled CAS

Sequence

Ser-(2,3-Bispalmitoyloxypropyl)-Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe

Sequence Shortening

S-(2,3-Bispalmitoyloxypropyl)-CGDPKHPKSF

SMILES

O=C([C@H]1N(CCC1)C([C@H](CC(O)=O)NC(CNC([C@@H](N)CSCC(COC(CCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCC)=O)=O)=O)=O)N[C@@H](CCCCN)C(N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
FSL-1
Cat. No.:
HY-P2036
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