2. Gene
  3. TIE1 - tyrosine kinase with immunoglobulin like and EGF like domains 1 Gene

TIE1 - tyrosine kinase with immunoglobulin like and EGF like domains 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TIE; JTK14; LMPHM11

Gene ID: 7075 | Gene type: protein coding

About TIE1

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:43,300,982-43,323,108 (from NCBI)

This gene has 10 transcripts (splice variants), 204 orthologues, 53 paralogues and is associated with 1 phenotype. Broad expression in placenta (RPKM 23.3), fat (RPKM 19.2) and 21 other tissues.

Summary

This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

TIE1 Products(2)

mRNA Protein Name
NM_001253357.2 NP_001240286.1 tyrosine-protein kinase receptor Tie-1 isoform 2
NM_005424.5 NP_005415.1 tyrosine-protein kinase receptor Tie-1 isoform 1 precursor

TIE1 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (135 - 197)

hEGF

hEGF: Human growth factor-like EGF (243 - 255)

Ig_2

Ig_2: Immunoglobulin domain (370 - 443)

fn3

fn3: Fibronectin type III domain (455 - 531)

fn3

fn3: Fibronectin type III domain (557 - 631)

fn3

fn3: Fibronectin type III domain (645 - 728)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (840 - 1106)

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  • 1138 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase receptor Tie-1

tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1

Recombinant TIE1 Proteins

Cat. No. Product Name Accession Purity
HY-P71362 TIE-1 Protein, Human (HEK293, His) P35590 (A22-Q760) ≥95%

Related Diseases

Diseases Alias
Lymphatic Malformation 11

LMPHM11
Angiosarcoma

Hemangiosarcoma
Malignant Renovascular Hypertension

Secondary Malignant Renovascular Hypertension
Primary Lymphedema

Lymphedema Primary
Inflammatory Breast Carcinoma

Inflammatory Breast Cancer

Inflammatory Carcinoma Of Breast

Mastitis Carcinomatosa

Breast Cancer, Inflammatory

Inflammatory Breast Neoplasms

Inflammatory Adenocarcinoma Of Breast
Breast Angiosarcoma

Angiosarcoma Of The Breast

Hemangiosarcoma Of The Breast

Primary Angiosarcoma Of Breast
Periodontosis

Periodontitis, Juvenile

Parodontosis

Paradentosis
Lymphangiosarcoma

Skin Lymphangiosarcoma

Stewart Treves Syndrome

Lymphangiosarcoma Of Stewart And Treves

Malignant Lymphangioendothelioma

Stewart-Treves Syndrome
Hemangioma

Hemangiomas
Malignant Secondary Hypertension
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14514 TIAL1 Human Pre-designed siRNA Set A / Unkown
HY-RS14520 TIE1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TIE1 VGNC VGNC:47366
Mus musculus TIE1 MGD MGI:99906
Bos taurus TIE1 VGNC VGNC:35861
Rattus norvegicus TIE1 RGD RGD:621642
Felis catus TIE1 VGNC VGNC:80380
Macaca mulatta TIE1 VGNC VGNC:78355
Others TIE1 NCBI