2. Protein Tyrosine Kinase/RTK Anti-infection Autophagy
  3. Bcr-Abl PDGFR c-Kit SARS-CoV Autophagy
  4. Imatinib-d4

Imatinib-d4  (Synonyms: STI571 d4; CGP-57148B d4)

Cat. No.: HY-15463S1 Purity: 99.97%
COA Handling Instructions

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Imatinib-d4 is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2].

For research use only. We do not sell to patients.

Imatinib-d<sub>4</sub> Chemical Structure

Imatinib-d4 Chemical Structure

CAS No. : 1134803-16-9

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1 mg USD 250 In-stock
5 mg USD 550 In-stock
10 mg USD 960 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Imatinib-d4 is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2].

Molecular Weight

497.63

Formula

C29H27D4N7O
CAS No.
Unlabeled CAS

152459-95-5
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C4=C([2H])C([2H])=C(CN5CCN(C)CC5)C([2H])=C4[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (25.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 10 mg/mL (20.10 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0095 mL 10.0476 mL 20.0953 mL
5 mM 0.4019 mL 2.0095 mL 4.0191 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.97%

COA (246 KB) HNMR (116 KB) RP-HPLC (375 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.0095 mL 10.0476 mL 20.0953 mL 50.2381 mL
5 mM 0.4019 mL 2.0095 mL 4.0191 mL 10.0476 mL
10 mM 0.2010 mL 1.0048 mL 2.0095 mL 5.0238 mL
15 mM 0.1340 mL 0.6698 mL 1.3397 mL 3.3492 mL
20 mM 0.1005 mL 0.5024 mL 1.0048 mL 2.5119 mL
DMSO 25 mM 0.0804 mL 0.4019 mL 0.8038 mL 2.0095 mL
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Imatinib-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imatinib-d41134803-16-9STI571 d4CGP-57148B d4Bcr-AblPDGFRc-KitSARS-CoVAutophagyPlatelet-derived growth factor receptorSCFRCD117SARS coronavirusdeuteriumImatinibtyrosinekinasesautophosphorylationInhibitorinhibitorinhibit

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