2. Cell Cycle/DNA Damage Cytoskeleton
  3. PAK
  4. NVS-PAK1-C

NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM).

For research use only. We do not sell to patients.

NVS-PAK1-C Chemical Structure

NVS-PAK1-C Chemical Structure

CAS No. : 2250019-95-3

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5 mg USD 390 In-stock
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Based on 1 publication(s) in Google Scholar

NVS-PAK1-C Related Antibodies

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Description

NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM)[1].

IC50 & Target[1]

PAK1

0.007 μM (Kd)

PAK2

0.4 μM (Kd)

PAK1

5 nM (IC50)

PAK2

270 nM (IC50)

In Vitro

NVS-PAK1-1 potently inhibits autophosphorylation of PAK1 (S144) at 0.25 µM in the Su86.86 cell line and MEK S289 phosphorylation with an IC50=0.21 µM in Su86.86 cells in which PAK2 is downregulated[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NVS-PAK1-C Related Antibodies
Molecular Weight

465.90

Formula

C22H23ClF3N5O
CAS No.
Unlabeled Cas

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C[C@@H](NC2=NC3=CC(F)=CC=C3N(CC(F)F)C4=CC=C(Cl)C=C42)CC1)N(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

COA (253 KB)

Handling Instructions (2659 KB)
References
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NVS-PAK1-C Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NVS-PAK1-C2250019-95-3PAKp21 activated kinasesPAK1Su86.86dephosphorylatedphosphorylatedprobeATP-competitiveInhibitorinhibitorinhibit

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