2. PI3K/Akt/mTOR
  3. mTOR
  4. P-2281

P-2281 is a mTOR inhibitor with anticancer and anti-inflammatory efficacies. P-2281 suppresses dextran sulfate sodium (DSS)-induced colitis by inhibiting T cell function and is efficacious in a murine model of human colitis.

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P-2281 Chemical Structure

P-2281 Chemical Structure

CAS No. : 1112994-35-0

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1 mg USD 195 In-stock
5 mg USD 480 In-stock
10 mg USD 690 In-stock
25 mg USD 1180 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

P-2281 is a mTOR inhibitor with anticancer and anti-inflammatory efficacies. P-2281 suppresses dextran sulfate sodium (DSS)-induced colitis by inhibiting T cell function and is efficacious in a murine model of human colitis[1].

Molecular Weight

209.63

Formula

C9H8ClN3O
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

CC(C(NC1=CC=C(N=C1)C#N)=O)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (596.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7703 mL 23.8515 mL 47.7031 mL
5 mM 0.9541 mL 4.7703 mL 9.5406 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7703 mL 23.8515 mL 47.7031 mL 119.2577 mL
5 mM 0.9541 mL 4.7703 mL 9.5406 mL 23.8515 mL
10 mM 0.4770 mL 2.3852 mL 4.7703 mL 11.9258 mL
15 mM 0.3180 mL 1.5901 mL 3.1802 mL 7.9505 mL
20 mM 0.2385 mL 1.1926 mL 2.3852 mL 5.9629 mL
25 mM 0.1908 mL 0.9541 mL 1.9081 mL 4.7703 mL
30 mM 0.1590 mL 0.7951 mL 1.5901 mL 3.9753 mL
40 mM 0.1193 mL 0.5963 mL 1.1926 mL 2.9814 mL
50 mM 0.0954 mL 0.4770 mL 0.9541 mL 2.3852 mL
60 mM 0.0795 mL 0.3975 mL 0.7951 mL 1.9876 mL
80 mM 0.0596 mL 0.2981 mL 0.5963 mL 1.4907 mL
100 mM 0.0477 mL 0.2385 mL 0.4770 mL 1.1926 mL
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P-2281 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P-22811112994-35-0P2281P 2281mTORMammalian target of RapamycinmTOR inhibitoranticanceranti-inflammatory efficaciescolitisInhibitorinhibitorinhibit

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