Pandinotoxin Kα 

Pandinotoxin Kα, isolated from the venom of Pandinus imperator, is the inhibitor of A-type potassium channel^[1].

4033.71

C₁₆₉H₂₆₇N₅₃O₄₈S₇

185529-64-0

Thr-Ile-Ser-Cys-Thr-Asn-Pro-Lys-Gln-Cys-Tyr-Pro-His-Cys-Lys-Lys-Glu-Thr-Gly-Tyr-Pro-Asn-Ala-Lys-Cys-Met-Asn-Arg-Lys-Cys-Lys-Cys-Phe-Gly-Arg (Disulfide bridge: Cys4-Cys25,Cys10-Cys30,Cys14-Cys32)

TISCTNPKQCYPHCKKETGYPNAKCMNRKCKCFGR (Disulfide bridge: Cys4-Cys25,Cys10-Cys30,Cys14-Cys32)

O=C(NC(C(C)CC)C(NC(CO)C(N[C@H](CSSCC(C(NC(CCSC)C(NC(CC(N)=O)C(NC(CCCNC(N)=N)C(NC1CCCCN)=O)=O)=O)=O)NC2=O)C(NC(C(O)C)C(N[C@@H](CC(N)=O)C(N3C(CCC3)C(N[C@@H](CCCCN)C(NC(CCC(N)=O)C(NC(CSSCC(C(NC4CCCCN)=O)NC1=O)C(NC(CC5=CC=C(C=C5)O)C(N6C(CCC6)C(NC(CC7=CNC=N7)C(N[C@H](CSSCC(C(NC(CC8=CC=CC=C8)C(NCC(NC(CCCNC(N)=N)C(O)=O)=O)=O)=O)NC4=O)C(NC(CCCCN)C(N[C@H](CCCCN)C(NC(CCC(O)=O)C(N[C@H]([C@H](O)C)C(NCC(N[C@@H](CC9=CC=C(C=C9)O)C(N%10[C@@H](CCC%10)C(NC(CC(N)=O)C(NC(C)C(NC2CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. T C Tenenholz, et al. Solution Structure for Pandinus Toxin K-α (PiTX-Kα), a Selective Blocker of A-Type Potassium Channels. Biochemistry. 1997 Mar 11;36(10):2763-71.  [Content Brief]

  [2]. Targeting Kai-Zheng Duan, et al. A-type K(+) channels in primary sensory neurons for bone cancer pain in a rat model. Pain.2012 Mar;153(3):562-574.  [Content Brief]