2. GPCR/G Protein Neuronal Signaling
  3. CGRP Receptor
  4. PHM-27 (human)

PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC50 of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism.

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PHM-27 (human) Chemical Structure

PHM-27 (human) Chemical Structure

CAS No. : 87403-73-4

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5 mg USD 320 In-stock
10 mg USD 510 In-stock
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Based on 1 publication(s) in Google Scholar

PHM-27 (human) Related Antibodies

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Description

PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC50 of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism[1][2][3].

IC50 & Target

EC50: 11 nM (human calcitonin receptor)[2]
Molecular Weight

2985.41

Formula

C135H214N34O40S
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

Sequence

{His}{Ala}{Asp}{Gly}{Val}{Phe}{Thr}{Ser}{Asp}{Phe}{Ser}{Lys}{Leu}{Leu}{Gly}{Gln}{Leu}{Ser}{Ala}{Lys}{Lys}{Tyr}{Leu}{Glu}{Ser}{Leu}{Met}-NH2
Sequence Shortening

HADGVFTSDFSKLLGQLSAKKYLESLM-NH2
SMILES

[HADGVFTSDFSKLLGQLSAKKYLESLM-NH2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (33.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3350 mL 1.6748 mL 3.3496 mL
5 mM 0.0670 mL 0.3350 mL 0.6699 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3350 mL 1.6748 mL 3.3496 mL 8.3741 mL
5 mM 0.0670 mL 0.3350 mL 0.6699 mL 1.6748 mL
10 mM 0.0335 mL 0.1675 mL 0.3350 mL 0.8374 mL
15 mM 0.0223 mL 0.1117 mL 0.2233 mL 0.5583 mL
20 mM 0.0167 mL 0.0837 mL 0.1675 mL 0.4187 mL
25 mM 0.0134 mL 0.0670 mL 0.1340 mL 0.3350 mL
30 mM 0.0112 mL 0.0558 mL 0.1117 mL 0.2791 mL
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PHM-27 (human) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PHM-27 (human)87403-73-4CGRP ReceptorCalcitonin gene-related peptide receptorCalcitonindiabetespreprovasoactiveintestinalpolypeptideglucoseautocrineInhibitorinhibitorinhibit

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