2. PROTAC
  3. PROTAC Linkers
  4. (+)-Biotin-ONP

(+)-Biotin-ONP  (Synonyms: (+)-Biotin 4-nitrophenyl ester)

Cat. No.: HY-130888
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(+)-Biotin-ONP is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

(+)-Biotin-ONP Chemical Structure

(+)-Biotin-ONP Chemical Structure

CAS No. : 33755-53-2

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250 mg USD 80 In-stock
500 mg USD 128 In-stock
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(+)-Biotin-ONP Related Antibodies

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Description

(+)-Biotin-ONP is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl-Chain

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(+)-Biotin-ONP Related Antibodies
Molecular Weight

365.40

Formula

C16H19N3O5S
CAS No.
Unlabeled Cas

Appearance

Solid

Color

White to off-white

SMILES

O=C(OC1=CC=C([N+]([O-])=O)C=C1)CCCC[C@@H]2SC[C@]([C@]2([H])N3)([H])NC3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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(+)-Biotin-ONP Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-Biotin-ONP33755-53-2(+)-Biotin 4-nitrophenyl esterPROTAC LinkersInhibitorinhibitorinhibit

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