2. Stem Cell/Wnt
  3. Smo
  4. Purmorphamine

Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM.

For research use only. We do not sell to patients.

Purmorphamine Chemical Structure

Purmorphamine Chemical Structure

CAS No. : 483367-10-8

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Purmorphamine Related Antibodies

Top Publications Citing Use of Products

    Purmorphamine purchased from MedChemExpress. Usage Cited in: Cancer Med. 2018 Nov;7(11):5704-5715.  [Abstract]

    The Hh signaling pathway is involved in DHA induced inhibition of cell proliferation. A and B, CCK8 assay of SKOV3 and SKOV3-IP cells is conducted following treatment with purmorphamine, DHA or a combination of DHA and purmorphamine for 48 h. C and D, SKOV3 and SKOV3‐IP cells are treated with GANT61, DHA, or a combination of DHA and GATN61 for 48 h, while controls are treated with DMSO. CCK8 assay is used to analyze cell viability of SKOV3 and SKOV3-IP cells.

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    Description

    Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM[1].

    In Vitro

    Purmorphamine (GMP) (1.5 μM, 1 week) can generate embryoid bodies (EBs) from human iPS cells (hiPS2) and hESCs (HSF1)[1].
    Purmorphamine (GMP) (1.5 μM) converts hPSCs to NKX2-1 positive MGE cells[2].
    Purmorphamine (GMP) (2 μM, day 28-35) promotes ventralization of the brain spheroids in differentiation process from hiPSCs[3].
    Purmorphamine (GMP) (1 μM) together with retinoic acid (RA, 2 μM) promotes hiPSC differentiation into functional neural tissue, indicated by the expression of neuronal marker β-tubulin III (βT-III)[4].
    Purmorphamine (GMP) (day5-7) induces hESCs differentiation into dopaminergic (DA) neurons[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Purmorphamine Related Antibodies
    Molecular Weight

    520.62

    Formula

    C31H32N6O2
    CAS No.
    Unlabeled CAS

    SMILES

    N1(C2=CC=C(NC3=NC(OC4=CC=CC5=C4C=CC=C5)=NC6=C3N=CN6C7CCCCC7)C=C2)CCOCC1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Purmorphamine Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Purmorphamine (GMP)483367-10-8SmoSmoothenedGMPcell therapydifferentiatecardiachiPSCsstem cellhESCneuronInhibitorinhibitorinhibit

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