2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Resiquimod

Resiquimod (R848) (GMP) is Resiquimod (HY-13740) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist. Resiquimod (GMP) can induce human mMDSC to mature into inflammatory macrophages.

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Resiquimod Chemical Structure

Resiquimod Chemical Structure

CAS No. : 144875-48-9

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Resiquimod Related Antibodies

Top Publications Citing Use of Products

54 Publications Citing Use of MCE Resiquimod

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    Resiquimod purchased from MedChemExpress. Usage Cited in: Cancer Gene Ther. 2023 Feb 13.  [Abstract]

    Resiquimod (10-200 μM) reduces E-cadherin and Wnt5a expression in a dose-dependent manner.

    Resiquimod purchased from MedChemExpress. Usage Cited in: Cytokine. 2017 Nov;99:310-315.  [Abstract]

    IL-23 production by macrophages after stimulation with LPS or Resiquimod M1 macrophages (day 9) were stimulated with LPS (10 ng) or Resiquimod (5 μM) for 6 h and IL-23 protein is measured by ELISA.

    Resiquimod purchased from MedChemExpress. Usage Cited in: J Interferon Cytokine Res. 2016 Sep;36(9):563-72.  [Abstract]

    With the stimulus of agonists LPS, ODN2006, Poly (I: C), and R848, the mRNA levels of goOASL in PBMCs are significantly upregulated in LPS- and Poly (I: C)-treated groups, and extremely upregulated in ODN2006- and R848-treated groups.

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    Description

    Resiquimod (R848) (GMP) is Resiquimod (HY-13740) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist. Resiquimod (GMP) can induce human mMDSC to mature into inflammatory macrophages[1][2][3].

    IC50 & Target[1]

    TLR7

     

    TLR8

     

    In Vitro

    Resiquimod (GMP) (3 µg/mL, 5 days) induces human mMDSC to mature into inflammatory macrophage (MACinflam)[1].
    Resiquimod (GMP) (3 µg/mL, 3 days) produces IL-6 and IL-12 in human mMDSC[1].
    Resiquimod (GMP) (2.5 µg/mL, 7 days) transdifferentiaes memory B cells to IgG producing plasma cells[2].
    Resiquimod (GMP) (5 µg/mL, 5 days) induces the differentiation of MDSCs into mature myeloid cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Resiquimod Related Antibodies
    Clinical Trial
    Molecular Weight

    314.38

    Formula

    C17H22N4O2
    CAS No.
    Unlabeled CAS

    SMILES

    OC(C)(C)CN1C(COCC)=NC2=C1C3=CC=CC=C3N=C2N
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Resiquimod Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Resiquimod (GMP)144875-48-9R848 (GMP) S28463 (GMP)Toll-like Receptor (TLR)GMPcell therapydifferentiationMDSCmacrophagemyeloid cellInhibitorinhibitorinhibit

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