2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton
  3. ROCK
  4. Rhodblock 6

Rhodblock 6 is a Rho kinase (ROCK) inhibitor that inhibits phospho-MRLC (myosin regulatory light chain) localization.

For research use only. We do not sell to patients.

Rhodblock 6 Chemical Structure

Rhodblock 6 Chemical Structure

CAS No. : 886625-06-5

Size Price Stock Quantity
1 mg USD 180 In-stock
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Rhodblock 6 Related Antibodies

Top Publications Citing Use of Products

View All ROCK Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Rhodblock 6 is a Rho kinase (ROCK) inhibitor that inhibits phospho-MRLC (myosin regulatory light chain) localization[1].

In Vitro

Rhodblock 6 (1-30 μM) inhibits ROCK activity robustly and in a dose-dependent manner. Rhodblock 6 also inhibits its human ortholog, ROCK I, and Rhodblock 6 (100 μM; 20 h) causes the disruption of stress fibers in human HeLa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rhodblock 6 Related Antibodies
Molecular Weight

215.25

Formula

C12H13N3O
CAS No.
Unlabeled CAS

Appearance

Solid

Color

Pale purple to purple

SMILES

O=C(NC1=CC2=C(C=C1)NN=C2)C3CCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (580.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6458 mL 23.2288 mL 46.4576 mL
5 mM 0.9292 mL 4.6458 mL 9.2915 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6458 mL 23.2288 mL 46.4576 mL 116.1440 mL
5 mM 0.9292 mL 4.6458 mL 9.2915 mL 23.2288 mL
10 mM 0.4646 mL 2.3229 mL 4.6458 mL 11.6144 mL
15 mM 0.3097 mL 1.5486 mL 3.0972 mL 7.7429 mL
20 mM 0.2323 mL 1.1614 mL 2.3229 mL 5.8072 mL
25 mM 0.1858 mL 0.9292 mL 1.8583 mL 4.6458 mL
30 mM 0.1549 mL 0.7743 mL 1.5486 mL 3.8715 mL
40 mM 0.1161 mL 0.5807 mL 1.1614 mL 2.9036 mL
50 mM 0.0929 mL 0.4646 mL 0.9292 mL 2.3229 mL
60 mM 0.0774 mL 0.3871 mL 0.7743 mL 1.9357 mL
80 mM 0.0581 mL 0.2904 mL 0.5807 mL 1.4518 mL
100 mM 0.0465 mL 0.2323 mL 0.4646 mL 1.1614 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Rhodblock 6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rhodblock 6886625-06-5Rhodblock6Rhodblock-6ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKmyosin regulatory light chainMRLCRho kinasephosphorylationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Rhodblock 6
Cat. No.:
HY-126913
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.