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Isoforms Recommended:	DYRK2

Results for "

DYRK2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Casein Kinase (1) CDK (4) DYRK (11) GSK-3 (1) Haspin Kinase (3) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Metabolic Disease (1) Neurological Disease (2)

Inhibitors & Agonists

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147066

Dyrk1A-IN-4	DYRK	Cancer
Dyrk1A-IN-4 (compound 48) is a potent and orally active *DYRK1A* and *DYRK2* inhibitor with IC₅₀s of 2 nM and 6 nM, respectively. Dyrk1A-IN-4 has anticancer effects .

HY-RS04098

DYRK2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DYRK2 Human Pre-designed siRNA Set A contains three designed siRNAs for DYRK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DYRK2 Human Pre-designed siRNA Set A DYRK2 Human Pre-designed siRNA Set A

HY-RS04099

Dyrk2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dyrk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dyrk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dyrk2 Mouse Pre-designed siRNA Set A Dyrk2 Mouse Pre-designed siRNA Set A

HY-RS04100

Dyrk2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dyrk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dyrk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dyrk2 Rat Pre-designed siRNA Set A Dyrk2 Rat Pre-designed siRNA Set A

HY-161014

DYRK2-IN-1

DYRK Cancer

DYRK2-IN-1 (Compd 54) is an orally bioavailable DYRK2 inhibitor, with an IC₅₀ of 14 nM. DYRK2-IN-1 (Compd 54) can be used in the study of prostate cancer .

DYRK2-IN-1	DYRK	Cancer
DYRK2-IN-1 (Compd 54) is an orally bioavailable *DYRK2* inhibitor, with an IC₅₀ of 14 nM. DYRK2-IN-1 (Compd 54) can be used in the study of prostate cancer .

HY-110320

LDN-209929 dihydrochloride	Haspin Kinase DYRK	Cancer
LDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC₅₀=55 nM) with180-fold selectivity verses DYRK2 (IC₅₀=9.9 μM). LDN-209929 is a optimized analogue of LDN-192960 (HY-13455) ^[2].

HY-13455

LDN-192960 2 Publications Verification	Haspin Kinase DYRK	Cancer
LDN-192960 is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC₅₀s of 10 nM and 48 nM, respectively .

HY-13455A

LDN-192960 hydrochloride 2 Publications Verification	Haspin Kinase DYRK	Cancer
LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC₅₀s of 10 nM and 48 nM, respectively .

HY-105309

GSK-626616 3 Publications Verification	DYRK	Cardiovascular Disease
GSK-626616 is a potent, orally bioavailable inhibitor of *DYRK3* (IC₅₀=0.7 nM). GSK-626616 inhibits other members of the DYRK family (e.g., DYRK1A and DYRK2) with similar potency, which is a potential therapy for the treatment of anemia .

HY-111379

EHT 5372	DYRK CDK GSK-3	Neurological Disease Metabolic Disease Cancer
EHT 5372 is a highly potent and selective inhibitor of *DYRK's* family kinases with IC₅₀s of 0.22, 0.28, 10.8, 93.2, 22.8, 88.8, 59.0, 7.44, and 221 nM for *DYRK1A, DYRK1B, DYRK2, DYRK*3, CLK1, CLK2, CLK4, GSK-3α, and GSK-3β, respectively ^[2].

HY-155723

Leucettinib-92	CDK DYRK	Others
Leucettinib-92 (compound 92) is an inhibitor of DYRK/CLK kinase, The IC₅₀s are 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM (CLK3), 124 nM (DYRK1A), 204 nM (DYRK1B), 0.16 μM (DYRK2), respectively. 1.0 μM (DYRK3), 0.52 μM (DYRK4), 2.78 μM (GSK3) .

HY-156816

ON 108600	Casein Kinase DYRK	Cancer
ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC₅₀s for *DYRK1A/DYRK*B, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity .

HY-117049

Leucettine L41	CDK DYRK	Neurological Disease
Leucettine L41 is a potent inhibitor of *dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3* (IC₅₀s = 0.04, 0.035, 0.015, and 4.5 µM, respectively) . Leucettine L41 prevents lipid peroxidation and the accumulation of reactive oxygen species (ROS) induced by Aβ_25-35 in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity. Leucettine L41 also prevents memory deficits induced by Aβ_25-35 in the same model ^[2].

HY-112296

T025 2 Publications Verification	CDK Apoptosis DYRK	Cancer
T025 is an orally active and highly potent inhibitor of Cdc2-like kinase (CLKs), with K_d values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5 and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B and DYRK2, respectively. T025 induces caspase-3/7-mediated cell apoptosis. T025 reduces CLK-dependent phosphorylation. T025 exerts anti-proliferative activities in both hematological and solid cancer cell lines (IC₅₀ values: 30-300 nM). T025 has an anti-tumor efficiency, mainly for MYC-driven disease research .

Cat. No.	Compare	Product Name	Species	Source

HY-P701672

	DYRK2 Protein, Human (GST) DYRK2; Dual specificity tyrosine-phosphorylation-regulated kinase 2	Human	E. coli
	DYRK2 is a multifunctional serine/threonine protein kinase that complexly controls multiple cellular processes, including the mitotic cell cycle, cell proliferation, apoptosis, cytoskeletal organization, and neurite outgrowth. DYRK2 operates downstream of ATM to phosphorylate p53/TP53 at the “Ser-46” site, leading to DNA damage-induced apoptosis. DYRK2 Protein, Human (GST) is the recombinant human-derived DYRK2 protein, expressed by E. coli , with N-GST labeled tag. The total length of DYRK2 Protein, Human (GST) is 600 a.a., .


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