Huntingtin

By Targets:	Huntingtin (8) Amylases (1) Amyloid-β (1) Apoptosis (1) Atg8/LC3 (3) ATTECs (2) Autophagy (4) Beclin1 (1) Cholinesterase (ChE) (1) GPR52 (1) Necroptosis (1) P-glycoprotein (1) Raf (1) RIP kinase (1) α-synuclein (1)
By Research Areas:	Inflammation/Immunology (2) Neurological Disease (15)

Targets Recommended: Huntingtin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-132579A

Tominersen sodium RG6042 sodium; IONIS-HTTRx sodium	Huntingtin	Neurological Disease
Tominersen sodium is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen sodium can be used for the research of Huntington’s disease (HD) .

HY-132579

Tominersen RG6042; IONIS-HTTRx	Huntingtin	Neurological Disease
Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD) .

HY-132593A

Rovanersen sodium WVE-120101 sodium	Huntingtin	Neurological Disease
Rovanersen sodium is an antisense oligonucleotide that specifically targets mutated mRNA copies of the huntington (HTT) gene without affecting healthy mRNA of HTT gene, thereby preventing the production of faulty *Huntingtin* protein. Rovanersen sodium can be used for huntington’s disease research .

HY-156103

mHTT-IN-2	Huntingtin	Neurological Disease
mHTT-IN-2 (compound 27) is a potent inhibitor (EC₅₀=0.066 μM) of mutant huntingtin (mHTT). mHTT-IN-2 reduces canonical splicing of HTT RNA exons [49-50] and is a splicing regulator of the huntingtin (HTT) gene. mHTT-IN-2 exhibits inhibitory activity in vitro and in vivo in human HD stem cells and mouse BACHD models. mHTT-IN-2 may be used in the study of branaplam-related peripheral neuropathy .

HY-10542A

(Z)-GW 5074	Atg8/LC3 Raf	Neurological Disease
(Z)-GW 5074 is a compound which interacts with both *mHTT (mutant huntingtin* protein) and LC3, but not but not with the wild-type HTT protein. (Z)-GW 5074 inhibits c-Raf**, shows no effect on autophagy, and is effective for neurodegenerative disorder .

HY-N2099

Onjisaponin B	Autophagy	Neurological Disease
Onjisaponin B is a natural product derived from Polygala tenuifolia. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells, and exbibits potential therapeutic effects on Parkinson disease and Huntington disease .

HY-150245

mHTT-IN-1	Huntingtin	Neurological Disease
mHTT-IN-1 (Example 1) is a potent mutant huntingtin (mHTT) inhibitor. mHTT is toxic and a major cause of the inherited autosomal dominant neurodegenerative disorder, Huntington's disease (HD). mHTT-IN-1 conducts the reduction of mHTT with an EC₅₀ value of 46 nM .

HY-161461

E234G HYPE-IN-1

Amylases Neurological Disease

E234G HYPE-IN-1 (Compound I2.10) is an AMPylase inhibitor with low cytotoxicity towards human cell lines .

E234G HYPE-IN-1	Amylases	Neurological Disease
E234G HYPE-IN-1 (Compound I2.10) is an AMPylase inhibitor with low cytotoxicity towards human cell lines .

HY-132593

Rovanersen WVE-120101	Huntingtin	Neurological Disease
Rovanersen (WVE-120101) is an antisense oligonucleotide that specifically targets mutated mRNA copies of the huntington (HTT) gene without affecting healthy mRNA of HTT gene, thereby preventing the production of faulty *Huntingtin* protein. Rovanersen can be used for huntington’s disease research .

HY-16009

Buntanetap (+)-Phenserine; ANVS401	Cholinesterase (ChE) Amyloid-β α-synuclein Huntingtin	Neurological Disease Inflammation/Immunology
Buntanetap ((+)-Phenserine) is a multiple neurotoxic protein translation inhibitor with oral activity, including amyloid precursor protein (APP), α-synuclein (αSYN) and huntingtin protein (HTT). Buntanetap has anti-inflammatory effects and can be used in the study of Alzheimer's disease and Parkinson's disease .

HY-145468

GPR52 antagonist-1	GPR52	Neurological Disease
GPR52 antagonist-1 (Compound 43) is a GPR52 antagonist with an IC₅₀ of 0.63 μM. GPR52 antagonist-1 reduces mHTT (mutant huntingtin protein) levels by targeting GPR52 and promotes survival of mouse primary striatal neurons .

HY-150236

FITC-labeled Tominersen sodium	Huntingtin	Neurological Disease
FITC-labeled Tominersen (sodium) is the Tominersen labeled with FITC. Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD).

HY-143792

HTT-D3	P-glycoprotein	Neurological Disease
HTT-D3 is a potent and orally active huntingtin (HTT) splicing modulator. HTT-D3 acts by promoting the inclusion of a pseudoexon containing a premature termination codon (stop-codon psiExon), leading to HTT mRNA degradation and reduction of HTT levels. HTT-D3 reduces p-glycoprotein (P-gp) efflux, and can be uesd for Huntington's disease research .

HY-130258

LC3-mHTT-IN-AN1	Atg8/LC3 ATTECs Autophagy	Neurological Disease
LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons .

HY-130259

LC3-mHTT-IN-AN2	Atg8/LC3 ATTECs Autophagy	Neurological Disease
LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons .

HY-134050

Apostatin-1 Apt-1	RIP kinase Autophagy Apoptosis Beclin1 Necroptosis	Inflammation/Immunology
Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 can bind with TRADD-N (K_D=2.17 μM), disrupting its binding to both TRADD-C and TRAF2. Apostatin-1 modulates the ubiquitination of RIPK1 and beclin 1. Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin .

HY-125172

PolyQ aggregation inhibitor C2-8 Polyglutamine Aggregation inhibitor III	Others	Others
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC₅₀s=25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease.

Cat. No.	Product Name	Type

HY-150236

FITC-labeled Tominersen sodium	Dyes
FITC-labeled Tominersen (sodium) is the Tominersen labeled with FITC. Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2099

Onjisaponin B	Triterpenes Neurological Disease Classification of Application Fields Terpenoids Source classification Polygalaceae Plants Disease Research Fields Polygala tenuifolia Willd.	Autophagy
Onjisaponin B is a natural product derived from Polygala tenuifolia. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells, and exbibits potential therapeutic effects on Parkinson disease and Huntington disease .

HY-130259

LC3-mHTT-IN-AN2	Structural Classification other families Source classification Coumarins Phenols Polyphenols Phenylpropanoids Plants	Atg8/LC3 ATTECs Autophagy
LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons .

Cat. No.	Compare	Product Name	Species	Source

HY-P71405

	UBE2K Protein, Human (GST) Ubiquitin-Conjugating Enzyme E2 K; Huntingtin-Interacting Protein 2; HIP-2; Ubiquitin Carrier Protein; Ubiquitin-Conjugating Enzyme E2-25 kDa; Ubiquitin-Conjugating Enzyme E2(25K); Ubiquitin-Conjugating Enzyme E2-25K; Ubiquitin-Protein Ligase; UBE2K; HIP2; LIG	Human	E. coli
	UBE2K Protein, a vital component of the ubiquitin-proteasome system, functions as an E2 ubiquitin-conjugating enzyme, crucial for attaching ubiquitin to diverse substrates. In vitro, UBE2K catalyzes 'Lys-48'-linked polyubiquitin chains, particularly with or without the BRCA1-BARD1 E3 ligase complex. It participates in the selective degradation of short-lived proteins, including endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. UBE2K exhibits ubiquitination activity towards targets like huntingtin and p53/TP53, and potentially NF-kappa-B. Its role in viral infections involves contributing to MHC class I heavy chain degradation and participating in HPV E7 protein-dependent degradation of RB1. UBE2K Protein, Human (GST) is the recombinant human-derived UBE2K protein, expressed by E. coli, with N-GST labeled tag. The total length of UBE2K Protein, Human (GST) is 200 a.a., with molecular weight of ~45.0 kDa.


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HY-P80188

	Huntingtin Antibody	WB, IHC-P, FC	Human, Mouse, Rat
	Huntingtin Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 348 kDa, targeting to Huntingtin. It can be used for WB,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P81778

HIP1 Antibody (YA1523)

HIP 1; hip1; HIP1/PDGFRB fusion gene; HIPI; Huntingtin interacting protein 1
WB, ICC/IF, IP Human, Mouse, Rat

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Huntingtin

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