dimer

By Targets:	ADC Cytotoxin (6) Adrenergic Receptor (1) Amyloid-β (1) Apoptosis (6) Bacterial (1) BCRP (1) Biochemical Assay Reagents (8) Btk (5) Caspase (2) Cytochrome P450 (2) DNA Alkylator/Crosslinker (5) DNA Stain (1) Dopamine Receptor (1) Drug Metabolite (2) Drug-Linker Conjugates for ADC (4) Endogenous Metabolite (5) Fluorescent Dye (6) Fungal (2) GLP Receptor (2) HIV (1) HSP (1) Isotope-Labeled Compounds (3) Keap1-Nrf2 (1) Liposome (1) LOX-1 (1) LXR (1) Microtubule/Tubulin (4) Molecular Glues (1) Neurokinin Receptor (1) NF-κB (8) Oxytocin Receptor (2) P-glycoprotein (1) PD-1/PD-L1 (2) Phosphodiesterase (PDE) (1) PKC (1) Potassium Channel (1) PROTAC Linkers (2) Raf (1) RAR/RXR (1) Reactive Oxygen Species (1) Sodium Channel (1) STING (4) TAM Receptor (2) TGF-beta/Smad (1) TRP Channel (1) Vasopressin Receptor (2)
By Research Areas:	Cancer (44) Cardiovascular Disease (5) Endocrinology (7) Infection (7) Inflammation/Immunology (18) Metabolic Disease (11) Neurological Disease (5)
Click Chemistry:	PROTAC Synthesis (2) Alkynes (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148424

*PBD dimer-2*	ADC Cytotoxin	Cancer
PBD dimer-2 (compound 2c) is a C8-linked pyrrolobenzodiazepine dimer. PBD dimer-2 can span an extra base pair and cross-link the 5′-Pu-GA(T/A)TC-Py sequence. PBD dimer-2 can be used as a payload for antibody–agent conjugates (ADCs), and it can be used for the research of cancer .

HY-141514

MSA-2 dimer 1 Publications Verification	STING	Inflammation/Immunology Cancer
MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (K_d=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide .

HY-138291

Ethoxyquin dimer	Others	Inflammation/Immunology
Ethoxyquin dimer is a dimer of Ethoxyquin (HY-B1425). Ethoxyquin dimer is an antioxidant. Ethoxyquin dimer can more readily accumulate in liver and adipose tissue compared with Ethoxyquin. Ethoxyquin above 10?mg/kg shows hepatotoxicity in mice .

HY-136113

Ibrutinib dimer	Btk	Cancer
Ibrutinib dimer is a Dimer of Ibrutinib. Ibrutinib dimer is an impurity of Ibrutinib . Ibrutinib is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM .

HY-139673

BG dimer

Fluorescent Dye Others

BG dimer is a molecular dimer organic luminogen with aggregation-induced emission.
HY-141736S

Acetaminophen dimer-d6

Isotope-Labeled Compounds Others

Acetaminophen dimer-d₆ is the deuterium labeled Acetaminophen dimer[1].

BG dimer	Fluorescent Dye	Others
BG dimer is a molecular dimer organic luminogen with aggregation-induced emission.

*Acetaminophen dimer-d6*	Isotope-Labeled Compounds	Others
Acetaminophen dimer-d₆ is the deuterium labeled Acetaminophen dimer[1].

HY-N10638

*N-Acetyldopamine dimer-2*	Reactive Oxygen Species NF-κB	Inflammation/Immunology
N-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity .

HY-N10637

*N-Acetyldopamine dimer-1*	Others	Others
N-Acetyldopamine dimer-1 is a 2-(3',4'-dihydroxyphenyl)-1,4-benzodioxane derivative. N-Acetyldopamine dimer-1 is optically active, can be isolated from crude agent "Zentai," a cast-off shell of the cicada of Cryptotympana sp. (Cicadidae) .

HY-N10646

N-Acetyldopamine dimer-3

Others Metabolic Disease

N-Acetyldopamine dimer-3 (compound 11) is a natural product that can be found in Aspongopus chinensis .

*N-Acetyldopamine dimer-3*	Others	Metabolic Disease
N-Acetyldopamine dimer-3 (compound 11) is a natural product that can be found in Aspongopus chinensis .

HY-131449

*Terazosin dimer* impurity dihydrochloride**	Adrenergic Receptor	Others
Terazosin dimer impurity dihydrochloride, a dimer of Terazosin, is an impurity of Terazosin. Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist .

HY-P5213

*Vasopressin Dimer* (parallel) (TFA)**	Vasopressin Receptor Oxytocin Receptor	Endocrinology
Vasopressin Dimer (parallel) TFA is a parallel dimer of Vasopressin (HY-B1811). Vasopressin Dimer (parallel) TFA can activate four G protein-coupled receptors, V1aR, V1bR, V2R, and OTR .

HY-142217S

Quetiapine dimer impurity-d8

Drug Metabolite Isotope-Labeled Compounds Others

Quetiapine dimer impurity-d₈ is the deuterium labeled Quetiapine dimer impurity[1].

*Quetiapine dimer* impurity-d8**	Drug Metabolite Isotope-Labeled Compounds	Others
Quetiapine dimer impurity-d₈ is the deuterium labeled Quetiapine dimer impurity[1].

HY-P5214

*Vasopressin Dimer* (anti-parallel) (TFA)**	Vasopressin Receptor Oxytocin Receptor	Endocrinology
Vasopressin Dimer (anti-parallel) TFA is an anti-parallel dimer of Vasopressin (HY-B1811). Vasopressin Dimer (anti-parallel) TFA can activate four G protein-coupled receptors, V1aR, V1bR, V2R, and OTR .

HY-W033466

Dichloro(benzene)ruthenium(II) dimer Benzeneruthenium(II) chloride dimer	Biochemical Assay Reagents	Others
Benzeneruthenium(II) Chloride Dimer is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W012515

1,3-Dihydroxyacetone dimer	Biochemical Assay Reagents	Others
1,3-Dihydroxyacetone dimer can be used as an aldose, serving as a model compound for studying the structure and function of carbohydrates. 1,3-Dihydroxyacetone dimer is a kind of biological materials or organic compounds that are widely used in life science research .

HY-143859S

Metoprolol dimer-d10

Isotope-Labeled Compounds Others

Metoprolol dimer-d₁₀ is the deuterium labeled Nitrosotetracaine[1].

*Metoprolol dimer-d10*	Isotope-Labeled Compounds	Others
Metoprolol dimer-d₁₀ is the deuterium labeled Nitrosotetracaine[1].

HY-141410

*Fluticasone dimer* impurity**	Drug Metabolite	Others
Fluticasone dimer impurity is a dimeric impurity of Fluticasone Propionate . Fluticasone propionate is a corticosteroid with comparatively high receptor affinity and topical activity .

HY-101127

SGD-1882

PBD dimer
ADC Cytotoxin Cancer

SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.

SGD-1882 PBD dimer	ADC Cytotoxin	Cancer
SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.

HY-W033577

Tricarbonyldichlororuthenium(II) dimer CORM-2	Others	Inflammation/Immunology
Tricarbonyldichlororuthenium(II) dimer is a pharmacological donor of CO releasing. CO releases from Tricarbonyldichlororuthenium(II) dimer prevents gastric mucosal oxidative damage induced by ischemia/reperfusion (I/R) improving gastric blood flow (GBF), decreasing DNA oxidation and inflammatory response on systemic level .

HY-153804

Naphthyridine carbamate dimer NCD	Molecular Glues	Others
Naphthyridine caebamate dimer (NCD) is a DNA molecular glue that induces designed structural changes in target functional DNA to modulate function .

HY-N9150

Shizukaol A

Others Others

Shizukaol A is an sesquiterpene dimer that can be isolated from Chloranthus japonicas .

Shizukaol A	Others	Others
Shizukaol A is an sesquiterpene dimer that can be isolated from Chloranthus japonicas .

HY-133022

trans-2-Undecenoic acid (E)-2-Undecenoic acid; (E)-Undec-2-enoic acid	Others	Metabolic Disease
trans-2-Undecenoic acid ((E)-2-Undecenoic acid) is an α,β-unsaturated carboxylic acid and is characterized by acid dimers. The corresponding dimers are connected via intermolecular hydrogen bonds of the carboxylic groups C=O···H-O .

HY-W025817

Citrazinic acid	Fluorescent Dye	Others
Citrazinic acid is a weakly fluorescent compound whose optical properties are dependent on aggregation states and chemical environment. Citrazinic acid strongly tends to form dimers at high concentrations .

HY-N10766

Ampelopsin F	Others	Others
Ampelopsins F is a bridged plant oligostilbene that can be isolated from Ampelopsis brevipedunculata var. hancei roots. Ampelopsins F is a resveratrol dimer .

HY-139718

IMD-biphenylB	NF-κB	Inflammation/Immunology
IMD-biphenylB is a potent imidazoquinolinone-NF-κB immunomodulator dimer that inhibits tumor proliferation while induces low systemic inflammation and reduces adjuvant toxicity.

HY-W441004

DSPE-Thiol	Liposome	Others
DSPE-Thiol is a phophalipid capped with thiol group. The thiol capped head can selectively react with maleimide. DSPE-Thiol can also be used for the preparation of phospholipid dimers .

HY-B2224

Thiamine disulfide	HIV Endogenous Metabolite	Infection Metabolic Disease
Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity .

HY-101161

SG3199 2 Publications Verification	DNA Alkylator/Crosslinker ADC Cytotoxin	Cancer
SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249) .

HY-N8404

Chlorahololide C	Potassium Channel	Inflammation/Immunology
Chlorahololide C, a lindenane sesquiterpenoid dimer, is isolated from Chloranthus holostegius. Chlorahololide C is a potent and selective potassium channel blocker, with an IC₅₀ of 3.6 μM .

HY-101160

SG2057 DRG16	DNA Alkylator/Crosslinker ADC Cytotoxin	Cancer
SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent .

HY-128952

Tesirine 2 Publications Verification SG3249	Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker	Cancer
Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .

HY-120397

Bis-propargyl-PEG4	PROTAC Linkers	Infection Cancer
Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers . Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-77490A

1,3-Butanediol	Endogenous Metabolite	Cardiovascular Disease Neurological Disease
1,3-Butanediol, an ethanol dimer providing a source of calories for human nutrition. 1,3-Butanediol is converted in the body to β-hydroxybutyrate and has cerebral protective and hypoglycaemic effect .

HY-N6310

Talaromycesone A	Bacterial	Infection
Talaromycesone A is an oxaphenalenone dimer compound. Talaromycesone A exhibits potent antibacterial activities with an IC₅₀ of 3.70 μM, against human pathogenic Staphylococcus strains. Talaromycesone A displays potent acetylcholinesterase inhibitory activities with an IC₅₀ of 7.49 μM .

HY-D1660

Acridine homodimer NSC 219743	DNA Stain	Others
Acridine homodimer (NSC 219743), acridine dimer, is a fluorescence dye. Acridine homodimer emits a blue-green fluorescence when bound to DNA. Acridine homodimer has extremely high affinity for AT-rich regions of nucleic acids, can be used for chromosome banding .

HY-114348

N,N'-Diacetyl-L-cystine DiNAC; (Ac-Cys-OH)2	Others	Cardiovascular Disease
N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits .

HY-112636

Astrophloxine	Amyloid-β	Others
Astrophloxine is a fluorescent imaging probe capable of targeting antiparallel dimers. Astrophloxine can be used to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples of Alzheimer's disease (AD) mice .

HY-16182A

Ecamsule disodium	Biochemical Assay Reagents	Others
Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression .

HY-D0916

*Thiazole orange dimer* YOYO 1** YOYO 1; YOYO1	Fluorescent Dye
Thiazole orange dimer YOYO 1 is a green fluorescent dye used for DNA staining. It belongs to the monomethine cyanine dye family and is a tetracationic homodimer of oxazole yellow (abbreviated as YO, hence the name YOYO), usually provided as a tetraiodide salt. In aqueous buffer, the free YOYO-1 dye (λmax 458 nm; λmax 564 nm) has a very low fluorescence quantum yield, but after binding to double-stranded DNA through diintercalation, the fluorescence intensity is increased by 3200 times (λmax 489 nm; λmax 509 nm).

HY-N7980

Rubipodanone A	NF-κB	Cancer
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

HY-16182

Ecamsule	Biochemical Assay Reagents	Others
Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .

HY-N10577

Chlorfortunone A	TGF-beta/Smad	Cancer
Chlorfortunone A is a novel sesquiterpenoid dimers, can be isolated from the roots of Chloranthus fortunei. Chlorfortunone A inhibits transforming growth factor (TGF)-β activity .

HY-111009

Swinholide A	Fungal	Infection
Swinholide A is the actin-binding marine polyketide and dimerizes actin with the K_d of ~ 50 nM . Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity .

HY-N12704

N-Acetyldopamine dimers B

Others Others

N-Acetyldopamine dimers B is the dimer form of N-Acetyldopamine (HY-N7493) .

N-Acetyldopamine dimers B	Others	Others
N-Acetyldopamine dimers B is the dimer form of N-Acetyldopamine (HY-N7493) .

HY-125772

Acetyl podocarpic acid anhydride Acetylpodocarpic dimer; APD	LXR	Cardiovascular Disease
Acetyl podocarpic acid anhydride is a potent, semisynthetic liver X receptor(LXR) agonist derived from extracts of the mayapple. Acetyl podocarpic acid anhydride has the potential to be useful for the prevention and research of atherosclerosis, especially in the context of low HDL levels .

HY-139714

IMD-vanillin

NF-κB Cancer

IMD-vanillin is a novel imidazoquinolinone-NF-κB immunomodulator dimers.

IMD-vanillin	NF-κB	Cancer
IMD-vanillin is a novel imidazoquinolinone-NF-κB immunomodulator dimers.

HY-126649

Bacillosporin C	Others	Infection
Bacillosporin C is an oxaphenalenone dimer originally isolated from T. bacillosporus. Bacillosporin C, an anhydride, is formed from the lactone bacillosporin D in the mangrove endophytic fungus SBE-14. Similar oxaphenalenone dimers have antibiotic activity and inhibit acetylcholinesterase.

HY-150265

TNH

TMP-NVOC linker-Halo
Others Others

TNH is a dimer that can enter living cells and recruit proteins into cellular structures .

HY-145736A

β-Glucuronide-dPBD-PEG5-NH2 TFA	Drug-Linker Conjugates for ADC Apoptosis	Cancer
β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity .

HY-145736

β-Glucuronide-dPBD-PEG5-NH2	Drug-Linker Conjugates for ADC Apoptosis	Cancer
β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 has antitumor activity .

Cat. No.	Product Name	Type

HY-D1815

Allophycocyanin 1 Publications Verification APC Dye	Dyes
Allophycocyanin (APC Dye) is a light-harvesting protein, containing strongly coupled dimers of chromophores. Allophycocyanin serve as a minimal system to examine photosynthetic energy transfer. Allophycocyanin strongly absorbs far-red light (FRL), and expresses during acclimation to low light, likely associates with chlorophyll a-containing photosystem I .

HY-131010

Flutax-2 (5/6-mixture)	Dyes
Flutax-2 (5/6-mixture) is an active fluorescent derivative of paclitaxel. Flutax-2 (5/6-mixture) binds to a polymerized α,β tubulin dimer. Excitation/emission wavelength: 496/524 nm. Paclitaxel, a diterpenoid secondary metabolite produced by Taxus species, can be used for the research of a variety of cancers .

HY-D0916

Thiazole orange dimer YOYO 1

YOYO 1; YOYO1

Dyes

Thiazole orange dimer YOYO 1 is a green fluorescent dye used for DNA staining. It belongs to the monomethine cyanine dye family and is a tetracationic homodimer of oxazole yellow (abbreviated as YO, hence the name YOYO), usually provided as a tetraiodide salt. In aqueous buffer, the free YOYO-1 dye (λmax 458 nm; λmax 564 nm) has a very low fluorescence quantum yield, but after binding to double-stranded DNA through diintercalation, the fluorescence intensity is increased by 3200 times (λmax 489 nm; λmax 509 nm).

Cat. No.	Product Name	Type

HY-W033466

Dichloro(benzene)ruthenium(II) dimer Benzeneruthenium(II) chloride dimer	Biochemical Assay Reagents
Benzeneruthenium(II) Chloride Dimer is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W441004

DSPE-Thiol	Drug Delivery
DSPE-Thiol is a phophalipid capped with thiol group. The thiol capped head can selectively react with maleimide. DSPE-Thiol can also be used for the preparation of phospholipid dimers .

HY-NP021

*Human D-dimer* protein** D dimer protein; D dimer antigen; Human D-dimer protein	Native Proteins
Human D-dimer protein is a good surrogate biomarker of thrombosis. Human D-dimer protein is the end product of fibrinolysis .

HY-W012515

1,3-Dihydroxyacetone dimer	Carbohydrates
1,3-Dihydroxyacetone dimer can be used as an aldose, serving as a model compound for studying the structure and function of carbohydrates. 1,3-Dihydroxyacetone dimer is a kind of biological materials or organic compounds that are widely used in life science research .

HY-154920

Dehydro-L-(+)-ascorbic acid dimer	Biochemical Assay Reagents
Dehydro-L-(+)-ascorbic acid dimer is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W019734

[Rh(Cp-)Cl2]2 Pentamethylcyclopentadienylrhodium(III) chloride dimer	Biochemical Assay Reagents
[Rh(Cp*)Cl2]2 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W018845

[Ir(Cp-)Cl2]2 Pentamethylcyclopentadienyliridium(III) chloride,dimer	Biochemical Assay Reagents
[Ir(Cp-)Cl2]2 is used as a precursor of hydrogenation catalyst for asymmetric transfer of ketones. [Ir(Cp-)Cl2]2 is an environmentally friendly catalyst for amine synthesis.

HY-W001951

Dirhodium tetraacetate Tetrakis(acetato)dirhodium(II); Rhodium(II) acetate dimer	Biochemical Assay Reagents
Dirhodium tetraacetate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W008260

[Ir(cod)Cl]2 Chloro-1,5-cyclooctadiene iridium(I) dimer	Biochemical Assay Reagents
[Ir(cod)Cl]2 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name	Target	Research Area

HY-P3222

Oxytocin antiparallel dimer	Peptides	Endocrinology
Oxytocin antiparallel dimer is the disulfide-bridged homo peptide dimer. Oxytocin dimer has oxytocin and vasopressin-like activity with less toxic than oxytocin .

HY-P3215

Oxytocin parallel dimer	Peptides	Endocrinology
Oxytocin parallel dimer is the disulfide-bridged homo peptide dimer. Oxytocin dimer has oxytocin and vasopressin-like activity with less toxic than oxytocin .

HY-P3215A

*Oxytocin parallel dimer* TFA**	Peptides	Endocrinology
Oxytocin parallel dimer TFA is the disulfide-bridged homo peptide dimer. Oxytocin dimer has oxytocin and vasopressin-like activity with less toxic than oxytocin .

HY-P10332

WL 47 dimer	Peptides	Others
WL 47 dimer (ligand 1) is a caveolin-1 (CAV-1) ligand with high affinity, selectivity and oligomer dissociation activity. WL 47 dimer simultaneously occupies two binding sites of CAV-1, inducing the dissociation of oligomers. WL 47 dimer has 7500-fold improved affinity compared to its T20 parent ligand and an 80% decrease in sequence length. WL 47 dimer can be used to permit targeted study of CAV-1 function .

HY-P3222A

*Oxytocin antiparallel dimer* TFA**	Peptides	Endocrinology
Oxytocin antiparallel dimer TFA is the disulfide-bridged homo peptide dimer. Oxytocin dimer has oxytocin and vasopressin-like activity with less toxic than oxytocin .

HY-P4957

*Octreotide dimer* (parallel)**	Peptides	Others
Octreotide dimer parallel is a dimer parallel of Octreotide. Octreotide (HY-P0036) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue .

HY-P5213

*Vasopressin Dimer* (parallel) (TFA)**	Vasopressin Receptor Oxytocin Receptor	Endocrinology
Vasopressin Dimer (parallel) TFA is a parallel dimer of Vasopressin (HY-B1811). Vasopressin Dimer (parallel) TFA can activate four G protein-coupled receptors, V1aR, V1bR, V2R, and OTR .

HY-P5214

*Vasopressin Dimer* (anti-parallel) (TFA)**	Vasopressin Receptor Oxytocin Receptor	Endocrinology
Vasopressin Dimer (anti-parallel) TFA is an anti-parallel dimer of Vasopressin (HY-B1811). Vasopressin Dimer (anti-parallel) TFA can activate four G protein-coupled receptors, V1aR, V1bR, V2R, and OTR .

HY-P3432

DfTat	Peptides	Others
DfTat is a dimer of the prototypical cell-penetrating peptide TAT. DfTat can deliver small molecules, peptides and proteins into live cells with a particularly high efficiency. DfTat labeled with the rhodamine can be used as a tracer for easy detection .

HY-P5340

Amyloid-Forming peptide GNNQQNY	Peptides	Others
Amyloid-Forming peptide GNNQQNY is a biological active peptide. (This is a heptapeptide from the N-terminal prion-determining domain of the yeast protein Sup35 that forms amyloid fibrils. The availability of its detailed atomic oligomeric structure makes it a good model for studying the early stage of aggregation. The GNNQQNY dimer forms three stable sheet structures. in-register parallel, off-register parallel, and anti-parallel. The in-register parallel dimer, which is close to the amyloid beta-sheet structure, has few interpeptide hydrogen bonds, making hydrophobic interactions more important and increasing the conformational entropy compared to the anti-parallel sheet.)

HY-P10438

Tat-braftide	Raf	Cancer
Tat-braftide is a peptide inhibitor designed to block the dimerization of BRAF, thereby inhibiting its kinase activity. The destruction of BRAF dimer by Tat-braftide makes BRAF protein more susceptible to proteasome degradation, directly inhibits the activity of BRAF kinase, and reduces the activation of MAPK signaling pathway. Tat-braftide can be used for the role of RAF kinase in MAPK signaling pathway and for the study of BRAF mutant cancers .

HY-108795A

Albiglutide fragment TFA GLP-1-Gly8 TFA; GLP-1 (7-36) analog TFA	GLP Receptor	Metabolic Disease
Albiglutide fragment (GLP-1 (7-36) analog) TFA is an active fragment of Albiglutide (7-36) and a glucagon-like peptide-1 (GLP-1) analog (a long-acting GLP-1 receptor agonist). Albiglutide is produced by the fusion of DPP-4 resistant GLP-1 dimer with the human albumin gene. Moreover, Albiglutide fragment TFA significantly reduces glycosylated hemoglobin (A1C) and is used in type 2 diabetes (T2D) studies .

HY-108795

Albiglutide fragment GLP-1-Gly8; GLP-1 (7-36) analog	GLP Receptor	Metabolic Disease
Albiglutide fragment (GLP-1 (7-36) analog) is an active fragment of Albiglutide (7-36) and a glucagon-like peptide-1 (GLP-1) analog (a long-acting GLP-1 receptor agonist). Albiglutide is produced by the fusion of DPP-4 resistant GLP-1 dimer with the human albumin gene. Moreover, Albiglutide fragment significantly reduces glycosylated hemoglobin (A1C) and is used in type 2 diabetes (T2D) studies .

HY-P1441A

Mambalgin 1 TFA	Sodium Channel
Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC₅₀ values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.

HY-P3801

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) DiMe-C7	Neurokinin Receptor	Others Neurological Disease Metabolic Disease
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats .

Cat. No.	Product Name	Target	Research Area

HY-P9991

Osemitamab TST001	Inhibitory Antibodies	Cancer
Osemitamab is an IgG1 antibody targeting to human claudin-18.2. Osemitamab consists of human-Mus musculus monoclonal TST001 γ1-chain, disulfide with human-Mus musculus monoclonal TST001 κ-chain, dimer (ACI). Osemitamab in combination with Capecitabine (HY-B0016) and Oxaliplatin (HY-17371), can be used for G/GEJ cancer study .

HY-P99463

Batiraxcept AVB-S6-500	TAM Receptor	Cancer
Batiraxcept (AVB-S6-500) is a highly potent and specific AXL inhibitor, a recombinant fusion protein dimer containing the extracellular domain of human AXLM and human immunoglobulin G1 heavy chain (Fc). Batiraxcept binds to GAS6 and inhibits the interaction of GAS6 with AXL, thereby substantially reducing AXL signaled invasion and migration of highly metastatic cells in vitro and inhibiting metastatic disease in nonclinical models of aggressive human cancers. Batiraxcept is available for studies in advanced or metastatic clear cell renal cell carcinoma (ccRCC) and platinum sensitive recurrent ovarian cancer .

HY-P99734

Mipasetamab uzoptirine ADCT-601	TAM Receptor	Cancer
Mipasetamab uzoptirine (ADCT-601) is an AXL-targeted antibody-drug conjugates (ADCs). Mipasetamab uzoptirine consists of a humanized anti-AXL antibody, a cleavable linker and the potent pyrrolobenzodiazepine (PBD) dimer cytotoxin SG3199. Mipasetamab uzoptirine can be used for the research of cancers .

HY-P99668

Iparomlimab	PD-1/PD-L1	Cancer
Iparomlimab is an anti-human PD-1/CD279/PDCD1 IgG4κ antibody. Iparomlimab also targets to human monoclonal PSB103 γ4-chain, disulfided with human monoclonal PSB103 κ-chain to form a dimer. Iparomlimab can be used for Oncology research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9150

Shizukaol A	Structural Classification Terpenoids Sesquiterpenes Source classification Chloranthaceae Chloranthus japonicus Sieb. Plants	Others
Shizukaol A is an sesquiterpene dimer that can be isolated from Chloranthus japonicas .

HY-B2224

Thiamine disulfide	Infection Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	HIV Endogenous Metabolite
Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity .

HY-N8404

Chlorahololide C	Classification of Application Fields Chloranthus holostegius (Hand.-Mazz.) Pei et Shan Terpenoids Sesquiterpenes Source classification Chloranthaceae Plants Disease Research Fields Inflammation/Immunology	Potassium Channel
Chlorahololide C, a lindenane sesquiterpenoid dimer, is isolated from Chloranthus holostegius. Chlorahololide C is a potent and selective potassium channel blocker, with an IC₅₀ of 3.6 μM .

HY-77490A

1,3-Butanediol	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1,3-Butanediol, an ethanol dimer providing a source of calories for human nutrition. 1,3-Butanediol is converted in the body to β-hydroxybutyrate and has cerebral protective and hypoglycaemic effect .

HY-N10766

Ampelopsin F	Structural Classification Vitis coignetiae Source classification Phenols Polyphenols Plants Vitaceae	Others
Ampelopsins F is a bridged plant oligostilbene that can be isolated from Ampelopsis brevipedunculata var. hancei roots. Ampelopsins F is a resveratrol dimer .

HY-N6310

Talaromycesone A	Infection Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields	Bacterial
Talaromycesone A is an oxaphenalenone dimer compound. Talaromycesone A exhibits potent antibacterial activities with an IC₅₀ of 3.70 μM, against human pathogenic Staphylococcus strains. Talaromycesone A displays potent acetylcholinesterase inhibitory activities with an IC₅₀ of 7.49 μM .

HY-N7980

Rubipodanone A	Quinones Classification of Application Fields Rubia podantha Source classification Rubiaceae Plants Naphthalene Quinones Disease Research Fields Cancer	NF-κB
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

HY-N10577

Chlorfortunone A	Structural Classification Terpenoids Sesquiterpenes Chloranthaceae Plants Chloranthus fortunei (A. Gray) Solms-Laub	TGF-beta/Smad
Chlorfortunone A is a novel sesquiterpenoid dimers, can be isolated from the roots of Chloranthus fortunei. Chlorfortunone A inhibits transforming growth factor (TGF)-β activity .

HY-111009

Swinholide A	Infection Structural Classification Natural Products Classification of Application Fields Animals Source classification Marine natural products Sponge Disease Research Fields	Fungal
Swinholide A is the actin-binding marine polyketide and dimerizes actin with the K_d of ~ 50 nM . Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity .

HY-N12704

N-Acetyldopamine dimers B	Structural Classification Animals Source classification Phenols Polyphenols	Others
N-Acetyldopamine dimers B is the dimer form of N-Acetyldopamine (HY-N7493) .

HY-N3393

Lethedioside A	Aquilaria agallocha Roxb. Structural Classification Flavonoids Flavones Thymelaeaceae Source classification Plants	Others
Lethedioside A is an Enhancer of split 1 (Hes1) dimer inhibitor with an IC₅₀ value of 9.5 μM .

HY-N1350

Riligustilide	Structural Classification Natural Products Source classification Plants Umbelliferae Echinacea angustifolia DC.	Others
Riligustilide (compound 2) is a kind of phthalide dimer. Riligustilide can be isolated from the radix of Angelica sinensis .

HY-N7697B

Chitobiose dihydrochloride	Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields Saccharides	Others
Chitobiose dihydrochloride, a chitosan oligosaccharide, is a dimer of β-1,4-linked glucosamine units .

HY-N3671

Cycloshizukaol A	Structural Classification Chloranthus serratus (Thunb.) Roem. et Schult. Terpenoids Sesquiterpenes Source classification Chloranthaceae Plants	Others
Cycloshizukaol A is a symmetrical cyclic lindenane dimer with C2 symmetry. Cycloshizukaol A can be isolated from the root of Chloranthus serratus .

HY-N2083

Handelin	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Genista vuralii A.Duran & Dural Plants Compositae Inflammation/Immunology Disease Research Fields	NF-κB
Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production .

HY-N7697F

Chitobiose	Polysaccharides Microorganisms Classification of Application Fields Animals Source classification Other Diseases Disease Research Fields Saccharides	Others
Chitobiose, a chitosan oligosaccharide, is a dimer of β-1,4-linked glucosamine units . Chitobiose has orally activity and high antioxidant activity .

HY-N3574

Chloramultilide B	Structural Classification Chloranthus serratus (Thunb.) Roem. et Schult. Terpenoids Sesquiterpenes Source classification Chloranthaceae Plants	Fungal
Chloramultilide B is a lindenane dimer that can be isolated from Chloranthus serratus. Chloramultilide B has inhibitory activities against Candida albicans and C.parapsilosis with a MIC value of 0.068 μM .

HY-130778

N,N'-Diacetylchitobiose	Structural Classification Microorganisms Classification of Application Fields Animals Source classification Other Diseases Disease Research Fields Saccharides	Endogenous Metabolite
N,N'-Diacetylchitobiose is a dimer of β(1,4) linked N-acetyl-D glucosamine. N,N'-Diacetylchitobiose is the hydrolysate of chitin and can be used as alternative carbon source by E. coli .

HY-N4299

Caesappanin C	Classification of Application Fields Leguminosae Caesalpinia sappan L. Source classification Other Phenylpropanoids Phenols Polyphenols Metabolic Disease Phenylpropanoids Plants Disease Research Fields	Others
Caesappanin C, a biphenyl dimer from the ethanolic extract of the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro. Caesappanin C has the potential to stimulate bone formation and regeneration .

HY-N2344

Procyanidin A1 1 Publications Verification Proanthocyanidin A1	Flavonoids other families Classification of Application Fields Functional Molecules Source classification Research of Health Products Phenols Polyphenols Plants Biflavones Disease Research Fields Inflammation/Immunology	PKC
Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca ²⁺ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects .

HY-N0282

Demecolcine 3 Publications Verification	Alkaloids Structural Classification other families Classification of Application Fields Other Alkaloids Source classification Plants Inflammation/Immunology Disease Research Fields	Microtubule/Tubulin Apoptosis
Demecolcine is a potent mitotic inhibitor with an IC₅₀ value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .

HY-N3841

ε-Viniferin 1 Publications Verification epsilon-Viniferin	Structural Classification Stilbenes Classification of Application Fields Source classification Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae Inflammation/Immunology Disease Research Fields	Cytochrome P450
ε-Viniferin (epsilon-Viniferin), the dimer of Resveratrol and can be isolated from Vitis vinifera, displays a potent inhibitory for all the CYP activities, with K_i values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant, anti-inflammatory, anti-diabetic, and anti-neurodegenerative capacity .

HY-N12235

Sarglaroids F	Structural Classification Ketones, Aldehydes, Acids Source classification Sarcandra glabra (Thunb.) Nakai Chloranthaceae Plants	Caspase
Sarglaroids F (compound 6) is an anti-inflammatory agent isolated from the roots of Grass Coral. Sarglaroids F inhibits LPS/ATP-induced IL-1β release by affecting K+ efflux and reducing Caspase-1(P20) levels. Sarglaroids F is not cytotoxic to RAW264.7 cells .

HY-N3841A

δ-Viniferin	Structural Classification Source classification Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae	Cytochrome P450
δ-Viniferin is a resveratrol dehydrodimer, an isomer of ε-Viniferin (HY-N3841) . ε-Viniferin (epsilon-Viniferin), the dimer of Resveratrol, displays a potent inhibitory for all the CYP activities, with K_i values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant, anti-inflammatory, anti-diabetic, and anti-neurodegenerative capacity.

HY-N0282R

Colcemid (Standard)	Alkaloids Structural Classification other families Other Alkaloids Source classification Plants	Microtubule/Tubulin Apoptosis
Colcemid (Standard) is the analytical standard of Colcemid. This product is intended for research and analytical applications. Colcemid (Demecolcine) is a potent mitotic inhibitor with an IC₅₀ value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .

HY-N11894

1,3,6-Trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside	Quinones Structural Classification Rubia podantha Anthraquinones Source classification Rubiaceae Plants	Others
1,3,6-Trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside ( Compound 20) is a quinone compound that can be isolated from the roots and rhizomes of Madder .

Cat. No.	Product Name	Chemical Structure

HY-141736S

Acetaminophen dimer-d6

Acetaminophen dimer-d₆ is the deuterium labeled Acetaminophen dimer[1].
HY-142217S

Quetiapine dimer impurity-d8

Quetiapine dimer impurity-d₈ is the deuterium labeled Quetiapine dimer impurity[1].
HY-143859S

Metoprolol dimer-d10

Metoprolol dimer-d₁₀ is the deuterium labeled Nitrosotetracaine[1].

Cat. No.	Product Name		Classification

HY-120397

Bis-propargyl-PEG4		Alkynes PROTAC Synthesis
Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers . Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133191

Bis-propargyl-PEG2		PROTAC Synthesis Alkynes
Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers . Bis-propargyl-PEG2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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