Search Result

Results for "

factor B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Akt (1) AMPK (1) Antibiotic (6) Apoptosis (11) Arp2/3 Complex (1) Bacterial (8) Bcl-2 Family (1) Calcineurin (1) CD28 (1) CFTR (2) Complement System (12) COX (3) EGFR (2) Endogenous Metabolite (3) Enterovirus (2) ERK (3) Eukaryotic Initiation Factor (eIF) (2) Factor Xa (7) FGFR (3) HIF/HIF Prolyl-Hydroxylase (6) Histone Demethylase (1) Histone Methyltransferase (1) HSP (1) IFNAR (1) IKK (1) Insulin Receptor (3) Interleukin Related (1) Isotope-Labeled Compounds (2) JNK (1) Keap1-Nrf2 (3) Leukotriene Receptor (1) Ligands for E3 Ligase (5) Lipoxygenase (1) mAChR (1) Molecular Glues (5) mTOR (1) NF-κB (9) NO Synthase (1) Nuclear Hormone Receptor 4A/NR4A (1) p38 MAPK (1) PAI-1 (1) Parasite (2) PDGFR (2) PGE synthase (1) Phosphatase (2) Platelet-activating Factor Receptor (PAFR) (2) PROTACs (1) RABV (1) Ras (1) SF3B1 (1) Sirtuin (1) STAT (1) Thrombin (6) TNF Receptor (4) Trk Receptor (1) VEGFR (2)
By Research Areas:	Cancer (38) Cardiovascular Disease (9) Infection (15) Inflammation/Immunology (35) Metabolic Disease (9) Neurological Disease (16)

By Targets:

5-HT Receptor (1)

Akt (1)

AMPK (1)

Antibiotic (6)

Apoptosis (11)

Arp2/3 Complex (1)

Bacterial (8)

Bcl-2 Family (1)

Calcineurin (1)

CD28 (1)

CFTR (2)

Complement System (12)

COX (3)

EGFR (2)

Endogenous Metabolite (3)

Enterovirus (2)

ERK (3)

Eukaryotic Initiation Factor (eIF) (2)

Factor Xa (7)

FGFR (3)

HIF/HIF Prolyl-Hydroxylase (6)

Histone Demethylase (1)

Histone Methyltransferase (1)

HSP (1)

IFNAR (1)

IKK (1)

Insulin Receptor (3)

Interleukin Related (1)

Isotope-Labeled Compounds (2)

JNK (1)

Keap1-Nrf2 (3)

Leukotriene Receptor (1)

Ligands for E3 Ligase (5)

Lipoxygenase (1)

mAChR (1)

Molecular Glues (5)

mTOR (1)

NF-κB (9)

NO Synthase (1)

Nuclear Hormone Receptor 4A/NR4A (1)

p38 MAPK (1)

PAI-1 (1)

Parasite (2)

PDGFR (2)

PGE synthase (1)

Phosphatase (2)

Platelet-activating Factor Receptor (PAFR) (2)

PROTACs (1)

RABV (1)

Ras (1)

SF3B1 (1)

Sirtuin (1)

STAT (1)

Thrombin (6)

TNF Receptor (4)

Trk Receptor (1)

VEGFR (2)

By Research Areas:

Cancer (38)

Cardiovascular Disease (9)

Infection (15)

Inflammation/Immunology (35)

Metabolic Disease (9)

Neurological Disease (16)

100

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

163

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136556

Factor B-IN-1

Complement System Inflammation/Immunology

Factor B-IN-1 is a Factor B inhibitor extracted from patent WO2013164802A1, Example 24 .

Factor B-IN-1	Complement System	Inflammation/Immunology
Factor B-IN-1 is a Factor B inhibitor extracted from patent WO2013164802A1, Example 24 .

HY-147605

Factor B-IN-3	Complement System	Inflammation/Immunology
Factor B-IN-3 (Example 3 target compound) is a potent *complement factor* B** inhibitor. Factor B-IN-3 can be used for the research of diseases related to inflammation and immunity .

HY-147606

Factor B-IN-4	Complement System	Inflammation/Immunology
Factor B-IN-4 (Example 13 target compound) is a potent *complement factor* B inhibitor, with an IC₅₀** of 1 μM. Factor B-IN-4 can be used for the research of diseases related to inflammation and immunity .

HY-147604

Factor B-IN-2	Complement System	Inflammation/Immunology
Factor B-IN-2 (Example 1 target compound) is a potent *complement factor* B inhibitor, with an IC₅₀** of 1.5 μM. Factor B-IN-2 can be used for the research of diseases related to inflammation and immunity .

HY-147607

Factor B-IN-5	Complement System	Inflammation/Immunology
Factor B-IN-5 (Example 5 target compound) is a potent *complement factor* B inhibitor, with an IC₅₀** of 1.2 μM. Factor B-IN-5 can be used for the research of diseases related to inflammation and immunity .

HY-N8118

Euphorbia factor L7b

Others Others

Euphorbia factor L7b is an isolathyrolditerpene compound .

*Euphorbia factor* L7b**	Others	Others
Euphorbia factor L7b is an isolathyrolditerpene compound .

HY-127105A

Iptacopan hydrochloride 3 Publications Verification LNP023 hydrochloride	Complement System	Metabolic Disease Inflammation/Immunology
LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor. LNP023 shows direct, reversible, and high-affinity binding to human factor B with a K_D of 7.9 nM. LNP023 inhibits factor B with an IC₅₀ value of 10 nM .

HY-148370A

IONIS-FB-LRx sodium RG6299 sodium	Complement System	Others
IONIS-FB-LRx sodium is a specific antisense oligonucleotide (ASO) targeting *complement factor* B (CFB)**. IONIS-FB-LRx sodium effectively reduces circulating levels of CFB, and can be used for geographic atrophy (GA) research .

HY-148370

IONIS-FB-LRx RG6299	Complement System	Others
IONIS-FB-LRx is a specific antisense oligonucleotide (ASO) targeting *complement factor* B (CFB)**. IONIS-FB-LRx effectively reduces circulating levels of CFB. IONIS-FB-LRx can be used for geographic atrophy (GA) research .

HY-127105

Iptacopan 3 Publications Verification LNP023	Complement System	Metabolic Disease Inflammation/Immunology
Iptacopan (LNP023) is a first-in-class, orally bioavailable, highly potent and highly selective factor B inhibitor with an IC₅₀ value of 10 nM. Iptacopan shows direct, reversible, and high-affinity binding to human factor B with a K_D of 7.9 nM. Iptacopan targets the underlying cause of complement 3 glomerulopathy (C3G) .

HY-N10431

Stigmane B	Keap1-Nrf2	Neurological Disease
Stigmane B (Compound 2) is a *nuclear factor* E2-related factor (Nrf2) activator. Stigmane B downregulates apoptosis and reactive oxygen species (ROS)** generation, and increases antioxidant enzyme activities. Stigmane B shows neuroprotective effects .

HY-122700

Factor D inhibitor 6	Complement System	Inflammation/Immunology
Factor D inhibitor 6 is a potent, highly selective and orally active factor D (FD) inhibitor with an IC₅₀ of 30 nM and a K_d of 6 nM. Factor D inhibitor 6 is inactive against factor B, lassical and lectin complement-pathway activation, and a broad assay panel of receptors, ion channels, kinases and proteases .

HY-160048

PEG40K unconjugated/naked AX102 sodium	PDGFR	Cancer
PEG40K unconjugated/naked AX102 sodium is AX102 without PEG40K conjugation. AX102 is a DNA oligonucleotide aptamer for platelet-derived growth factor PDGF-B. AX102 is 34 bases in length, selectively binds platelet-derived growth factor B (PDGF-B), and causes tumor vessel regression .

HY-B0441

Tobramycin 5+ Cited Publications Nebramycin factor 6; Deoxykanamycin B	Bacterial Antibiotic	Infection Cancer
Tobramycin (Nebramycin Factor 6) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms .Tobramycin can be used to pneumonia research caused by Pseudomonas aeruginosa .

HY-111492

DIM-C-pPhOCH3

Nuclear Hormone Receptor 4A/NR4A Cancer

DIM-C-pPhOCH₃ is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor.

DIM-C-pPhOCH3	Nuclear Hormone Receptor 4A/NR4A	Cancer
DIM-C-pPhOCH₃ is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor.

HY-N11640

Methyl Ganoderic acid B	Others	Neurological Disease
Methyl Ganoderic acid B is a triterpenoid, that can be isolated from Ganoderma lucidum. Methyl Ganoderic acid B has nerve growth factor-like neuronal survival-promoting effects .

HY-N12566

Erinacin B	Others	Neurological Disease
Erinacin B is a active product that can be extracts from the mycelia of Hericium erinaceum. Erinacin B shows potent stimulating activity of nerve growth factor (NGF)-synthesis .

HY-P9952

Belimumab 2 Publications Verification LymphoStat B	TNF Receptor	Inflammation/Immunology
Belimumab (LymphoStat B) is a human IgG1λ monoclonal antibody that inhibits *B-cell activating factor* (BAFF)**. Belimumab can be used for systemic lupus erythematosus (SLE) research .

HY-111053

P11	Others	Cancer
P11 is a selective inhibitor of platelet-activating factor acetylhydrolases (PAFAHs) 1b2 and 1b3 that impairs cancer cell survival. P11 exhibits IC₅₀ values of ~40 and 900 nM for PAFAH1b2 and 1b3, respectively .

HY-N10009

Cudraflavone B	NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin	Inflammation/Immunology
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of *nuclear factor* κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1**. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells .

HY-100540

Golgicide A 3 Publications Verification GCA	Enterovirus	Infection Cancer
Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1 . Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species .

HY-P99298

Lampalizumab RG 7417; TNX 234; Anti-CFD Recombinant Antibody	Complement System	Inflammation/Immunology
Lampalizumab (RG 7417) is a humanised monoclonal antibody targeting complement Factor D in the alternative complement pathway. Lampalizumab binds an exosite and sterically blocks Factor B access to the active site. Lampalizumab can be used for age-related macular degeneration (AMD) research .

HY-126307

Urolithin B 3 Publications Verification	NF-κB JNK ERK Akt AMPK Endogenous Metabolite	Inflammation/Immunology
Urolithin B is one of Ellagitannins' slow microbial products, and has anti-inflammatory and anti-inflammatory effects. Urolithin B suppresses NF-κB activity. Urolithin B suppresses JNK, ERK and Akt's oxidation, and increases AMPK's oxidation. Urolithin B is also a quantitative change factor for bone and skin quality.

HY-153480

ARC19499 BAX499	Factor Xa	Others
ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

HY-153480A

ARC19499 sodium BAX499 sodium	Factor Xa	Others
ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

HY-124875

Arylsulfonamide 64B HIF inhibitor 64B	HIF/HIF Prolyl-Hydroxylase	Neurological Disease
Arylsulfonamide 64B (HIF inhibitor 64B) is an inhibitor of the hypoxia-induced factor (HIF). Arylsulfonamide 64B inhibits hypoxia/HIF-induced expression of c-Met and CXCR4 and reduces primary tumor growth and metastasis of uveal melanoma mouse model .

HY-B0441A

Tobramycin sulfate 5+ Cited Publications Nebramycin factor 6 sulfate; Deoxykanamycin B sulfate	Bacterial Antibiotic	Infection Cancer
Tobramycin sulfate (Nebramycin Factor 6 sulfate) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms .

HY-110154

NSC636819	Histone Demethylase	Cancer
NSC636819 is a competitive and selective inhibitor of *KDM4A/KDM4B. KDM4A/KDM4B are potential progression factors* for prostate cancer. NSC636819 has the potential for the research of cancer diseases, especially prostate cancer .

HY-129973

4-Chlorophenylurea NSC-12971; 4-Chlorophenylurea	Others	Others
4-Chlorophenylurea is metabolite of diflubenzuron (HY-B1973). 4-Chlorophenylurea can be used to form factor Xa inhibitors .

HY-N11920

Kadsurenin B	Platelet-activating Factor Receptor (PAFR)	Infection Neurological Disease Inflammation/Immunology
Kadsurenin B is a PAF (platelet-activating factor) antagonist with neuroprotective activity. Kadsurenin B has a wide range of pharmacological research potential, such as antibacterial, anti-inflammatory, neuroprotective, antioxidant, antiplatelet aggregation, cytotoxic, antiparasitic, etc .

HY-112648

Stafib-2	STAT	Others
Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b, with an IC₅₀ of 82 nM and 1.7 μM for *STAT5b* and STAT5a, respectively. Stafib-2 exhibits poor cell permeability .

HY-111547

M1001	HIF/HIF Prolyl-Hydroxylase	Cancer
M1001 is a weak hypoxia-inducible factor-2α (HIF-2α) agonist. M1001 can bind to the HIF-2α PAS-B domain, with a K_d of 667 nM. M1001 can be used in chronic kidney disease research .

HY-P99010

Bemarituzumab	FGFR	Cancer
Bemarituzumab is a first-in-class, humanized IgG1 monoclonal antibody against *FGFR2b* (a FGF receptor). Bemarituzumab blocks fibroblast growth factors from binding and activating FGFR2b. Bemarituzumab has the potential for cancer research .

HY-160047

AX102 sodium	PDGFR	Cancer
AX102 sodium is a 34 bp length nucleotide aptamer modified at the 5' end with a 40 kDa polyethylene glycol moiety. AX102 selectively binds platelet-derived growth factor B (PDGF-B) and causes tumor vessel regression .

HY-100540A

(Rac)-Golgicide A (Rac)-GCA	Enterovirus	Infection
(Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A. Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1 .Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species .

HY-N10313

Dehydrobruceine B	Bcl-2 Family Keap1-Nrf2 Apoptosis	Cancer
Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce apoptosis via mitochondrial method. Dehydrobruceine B increases *apoptosis-inducing factor* (AIF) and Bax expression and suppresses Keap1-Nrf2** .

HY-117359

UCD38B hydrochloride	PAI-1 Apoptosis	Cancer
UCD38B hydrochloride is a cell permeant, competitive enzymatic uPA inhibitor with an IC₅₀ value of 7 μM. UCD38B hydrochloride targets intracellular uPA causing mistrafficking of uPA into perinuclear mitochondria, reducing the mitochondrial membrane potential, and followed by the release of apoptotic inducible factor (AIF). UCD38B hydrochloride induces apoptosis .

HY-N3938

Gelsemiol	Others	Neurological Disease
Gelsemiol is the main active ingredient in Verbena littoralis H. B. K.. Gelsemiol enhanced nerve growth factor (NGF) -induced axonal elongation in PC12D cells .

HY-P1799

[pTyr5] EGFR (988-993)	Phosphatase	Others
[pTyr5] EGFR (988-993) is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B) .

HY-P99465

Befovacimab BAY 1093884	Thrombin	Cardiovascular Disease
Befovacimab (BAY 1093884) is a fully human monoclonal IgG2 antibody able to bind to *tissue factor* pathway inhibitor (TFPI)**. Befovacimab can be used for haemophilia A/B research .

HY-P1799A

[pTyr5] EGFR (988-993) (TFA)	Phosphatase	Others
[pTyr5] EGFR (988-993) TFA is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) TFA is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B) .

HY-P3503

Vosoritide BMN 111	FGFR	Others
Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to *NPR-B* (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (*fibroblast growth factor* receptor 3**). Vosoritide can be used in achondroplasia and dwarfism research .

HY-N0784

Ginkgolide B 3 Publications Verification BN-52021	Platelet-activating Factor Receptor (PAFR) Apoptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments .

HY-P1108

Astressin 2B	CFTR	Others
Astressin 2B is a potent and selective *corticotropin-releasing factor* receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2**-mediated inhibition of gastric emptying .

HY-N4171

Dihydrocucurbitacin B	Apoptosis	Inflammation/Immunology
Dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, inhibits nuclear factor of activated T cells (NFAT), induces cell cycle arrested in the G0 phase, and inhibits delayed type hypersensitivity .

HY-P1108A

Astressin 2B TFA	CFTR	Others
Astressin 2B TFA is a potent and selective *corticotropin-releasing factor* receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B TFA antagonizes CRF2**-mediated inhibition of gastric emptying .

HY-N6701

Dihydrocytochalasin B	Arp2/3 Complex	Cancer
Dihydrocytochalasin B (H2CB) is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B; does not inhibit glucose transport . Dihydrocytochalasin B (H2CB) disrupts the actin structure and inhibits the ability of growth factors to stimulate DNA synthesis, reversibly blocks initiation of DNA synthesis . Dihydrocytochalasin B (H2CB) inhibits active calcium transport and causes a Ca ²⁺increase in the mucosal scrapings .

HY-N8936

Narchinol B	Others	Inflammation/Immunology
Narchinol B (Compound 4) is a sesquiter penoid compound. Narchinol B has anti-inflammatory effects. Narchinol B works by inhibiting proinflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as proinflammatory cytokines, such as interleukin-1b, IL-6, and tumor necrosis factor-α (TNF-α). Narchinol B significantly inhibits LPS-induced overproduction of NO in BV2 cells (IC₅₀=2.43 μM) .

HY-125021

2BAct 1 Publications Verification	Eukaryotic Initiation Factor (eIF)	Neurological Disease
2BAct is a highly selective, and orally active *eIF2B* (eukaryotic initiation factor 2B) activator with an EC₅₀ of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495) .

HY-P99563

Tibulizumab LY 3090106	TNF Receptor Interleukin Related	Inflammation/Immunology
Tibulizumab (LY 3090106) is a tetravalent bispecific monoclonal antibody targeting B-cell activating factor (BAFF) and IL-17A with Kd values of 60 pM and 14 pM, respectively. Tibulizumab can be used for autoimmune disease research .

Cat. No.	Product Name

HY-L014

NF-κB Signaling Compound Library

809 compounds

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.

MCE owns a unique collection of 809 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

HY-L156

Autoimmune Disease Compound Library

461 compounds

Autoimmune disease is a pathological disease characterized by inflammatory disorders targeting autoantigens. The routine treatment of autoimmune diseases suppresses general immune function to regulate uncontrolled inflammation. The current targeted immunotherapy suppresses the main pro-inflammatory signaling pathways by blocking inflammatory cytokines, cell surface molecules, and intracellular kinases. As key participants in innate immunity, macrophages and dendritic cells (DCs) are crucial for Ag presentation and pro-inflammatory cytokine production, such as TNF and IL-1 β、 IL-6, IL-23, B cell activating factor (BAFF), and the proliferation-inducing ligand (APRIL, also known as TNFSF13A).

MCE designs a unique collection of 461 autoimmune disease-related compounds, covering multiple targets and subtypes, such as TNF Receptor, IFNAR, JAK, Btk, TLR, IL-6, IL-17, IL-23, etc. It is a useful tool for screening autoimmune disease drugs.

HY-L101

Anti-Liver Cancer Compound Library

1,828 compounds

Liver cancer is one of the leading malignancies which occupies the second position in cancer deaths worldwide, becoming serious threat to human health. Hepatocellular carcinoma (HCC), also known as hepatoma is the most common type accounting for approximately 90% of all liver cancers.

Current evidence indicates that during hepatocarcinogenesis, two main pathogenic mechanisms prevail: (1) cirrhosis associated with hepatic regeneration after tissue damage caused by hepatitis infection, toxins or metabolic influences, and (2) mutations occurring in single or multiple oncogenes or tumor suppressor genes. Both mechanisms have been linked with alterations in several important cellular signaling pathways. These include the RAF/MEK/ERK pathway, PI3K/AKT/mTOR pathway, WNT/b-catenin pathway, insulin-like growth factor pathway, c-MET/HGFR pathway , etc.

MCE offers a unique collection of 1,828 compounds with identified and potential anti-liver cancer activity. MCE anti-liver cancer compound library is a useful tool for anti-liver cancer drugs screening and other related research.

Cat. No.	Product Name	Target	Research Area

HY-P3206

Serum thymic factor Thymulin; Thymic factor	Peptides	Inflammation/Immunology
Serum thymic factor (Thymulin) is a zinc-dependent immunomodulatory peptide. Serum thymic factor induces hyperalgesia. Serum thymic factor protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor has anti-diabetic, analgesic and anti-inflammatory effects .

HY-P1799

[pTyr5] EGFR (988-993)	Phosphatase	Others
[pTyr5] EGFR (988-993) is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B) .

HY-P1799A

[pTyr5] EGFR (988-993) (TFA)	Phosphatase	Others
[pTyr5] EGFR (988-993) TFA is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) TFA is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B) .

HY-P3503

Vosoritide BMN 111	FGFR	Others
Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to *NPR-B* (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (*fibroblast growth factor* receptor 3**). Vosoritide can be used in achondroplasia and dwarfism research .

HY-P1108

Astressin 2B	CFTR	Others
Astressin 2B is a potent and selective *corticotropin-releasing factor* receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2**-mediated inhibition of gastric emptying .

HY-P1108A

Astressin 2B TFA	CFTR	Others
Astressin 2B TFA is a potent and selective *corticotropin-releasing factor* receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B TFA antagonizes CRF2**-mediated inhibition of gastric emptying .

HY-P2093

S961	Insulin Receptor	Metabolic Disease
S961 is an high-affinity and selective insulin receptor (IR) antagonist with IC₅₀s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .

HY-P2093B

S961 acetate 4 Publications Verification	Insulin Receptor	Metabolic Disease
S961 acetate is an high-affinity and selective insulin receptor (IR) antagonist with IC₅₀s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .

HY-P1237

C-Type Natriuretic Peptide (CNP) (1-22), human 1 Publications Verification	Peptides	Cardiovascular Disease Neurological Disease Metabolic Disease
C-Type Natriuretic Peptide (CNP) (1-22), human, a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .

HY-P2093A

S961 TFA	Insulin Receptor	Metabolic Disease
S961 TFA is an high-affinity and selective insulin receptor (IR) antagonist with IC₅₀s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .

HY-P1237A

C-Type Natriuretic Peptide (CNP) (1-22), human TFA 1 Publications Verification	Peptides	Cardiovascular Disease Neurological Disease Metabolic Disease
C-Type Natriuretic Peptide (CNP) (1-22), human (TFA),a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .

HY-P5457

BMP-2 Epitope (73-92)	Peptides	Others
BMP-2 Epitope (73-92) is a biological active peptide. (This is amino acids 73 to 92 fragment of bone morphogenetic protein (BMP) knuckle epitope. It is a member of transforming growth factor beta (TGF-b). This peptide fragment is able to raise alkaline phosphate activity in murine multipotent mesenchymal cells.)

HY-P2324

Gramicidin A	Bacterial HIF/HIF Prolyl-Hydroxylase Antibiotic	Infection Cancer
Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α) .

HY-P2324A

Gramicidin A TFA	Antibiotic Bacterial	Infection
Gramicidin A (TFA) is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A (TFA) is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A (TFA) induces degradation of hypoxia inducible factor 1 α (HIF-1α) .

HY-P10223

Cyclo(CRVIIF)	HIF/HIF Prolyl-Hydroxylase	Cancer
Cyclo CRVIIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains K_D of 65 and 123 μM, respectively .

HY-P10222

Cyclo(CRLLIF)	HIF/HIF Prolyl-Hydroxylase	Cancer
Cyclo CRLLIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains K_D of 14.5 and 10.2 μM, respectively .

Cat. No.	Product Name	Target	Research Area

HY-P9952

Belimumab 2 Publications Verification LymphoStat B	TNF Receptor	Inflammation/Immunology
Belimumab (LymphoStat B) is a human IgG1λ monoclonal antibody that inhibits *B-cell activating factor* (BAFF)**. Belimumab can be used for systemic lupus erythematosus (SLE) research .

HY-P99840

Dalcinonacog alfa

CB-2679d; DalcA; ISU-304
Inhibitory Antibodies Others

Dalcinonacog alfa is a recombinant FIX factor that can be used in the study of Haemophilia B .

HY-112935

Nonacog alfa BAX326; Coagulation factor IX [Recombinant]	Inhibitory Antibodies	Others
Nonacog alfa (BAX326) is a recombinant human factor IX that can be used for the research of haemophilia B .

HY-P990378

Anti-Complement Factor P/Properdin Antibody

Inhibitory Antibodies Inflammation/Immunology
HY-P990377

Anti-Complement Factor B Antibody

Inhibitory Antibodies Inflammation/Immunology

HY-P99298

Lampalizumab RG 7417; TNX 234; Anti-CFD Recombinant Antibody	Complement System	Inflammation/Immunology
Lampalizumab (RG 7417) is a humanised monoclonal antibody targeting complement Factor D in the alternative complement pathway. Lampalizumab binds an exosite and sterically blocks Factor B access to the active site. Lampalizumab can be used for age-related macular degeneration (AMD) research .

HY-P99010

Bemarituzumab	FGFR	Cancer
Bemarituzumab is a first-in-class, humanized IgG1 monoclonal antibody against *FGFR2b* (a FGF receptor). Bemarituzumab blocks fibroblast growth factors from binding and activating FGFR2b. Bemarituzumab has the potential for cancer research .

HY-P99465

Befovacimab BAY 1093884	Thrombin	Cardiovascular Disease
Befovacimab (BAY 1093884) is a fully human monoclonal IgG2 antibody able to bind to *tissue factor* pathway inhibitor (TFPI)**. Befovacimab can be used for haemophilia A/B research .

HY-P99563

Tibulizumab LY 3090106	TNF Receptor Interleukin Related	Inflammation/Immunology
Tibulizumab (LY 3090106) is a tetravalent bispecific monoclonal antibody targeting B-cell activating factor (BAFF) and IL-17A with Kd values of 60 pM and 14 pM, respectively. Tibulizumab can be used for autoimmune disease research .

HY-P99666

Interferon alfa	IFNAR	Infection
Albinterferon alfa-2b is a type I interferon that activates novel genes and exerts potent antiviral and antiproliferative activity on target cells. Signaling by Albinterferon alfa-2b requires receptor-dependent activation of Stat1 and Stat2 to form a heterodimeric STAT that binds to the DNA-binding protein IRF-9 (p48) and forms ISGF-3 (IFN-stimulated gene factor 3). The driver genes are then further activated by ISGF-3 to achieve antiviral function .

HY-P99961

Tifcemalimab JS004	CD28	Cancer
Tifcemalimab (JS004) is a humanized anti-BTLA (B and T lymphocyte attenuation factor) monoclonal antibody. Tifcemalimab blocks the interaction of HVEM-BTLA by binding to BTLA, and thus blocks the inhibitory signaling pathway mediated by BTLA. Tifcemalimab can be used in research of cancer .

HY-P99220

Tabalumab LY2127399	TNF Receptor	Inflammation/Immunology
Tabalumab (LY2127399) is a human anti-BAFF (B-cell activating factor) monoclonal antibody (IgG4 type) with neutralising activity against membrane bound and soluble BAFF. Tabalumab can be used in studies of autoimmune diseases such as rheumatoid arthritis, renal failure and systemic lupus erythematosus .

HY-P99583

Suvratoxumab MEDI4893	Bacterial	Infection Inflammation/Immunology
Suvratoxumab (MEDI4893) is a long-acting, high-affinity human anti-α-toxin monoclonal antibody (IgG1κ type). Suvratoxumab potently neutralizes α-toxin, a key S. aureus virulence factor. Suvratoxumab improves survival and reduces lung injury in an immunocompromised mice model of pneumonia. Suvratoxumab also enhances the antibacterial activity of Vancomycin (HY-B0671) or Linezolid (HY-10394) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8118

*Euphorbia factor* L7b**	other families Classification of Application Fields Terpenoids Source classification Other Diseases Diterpenoids Plants Disease Research Fields	Others
Euphorbia factor L7b is an isolathyrolditerpene compound .

HY-B0441

Tobramycin 5+ Cited Publications Nebramycin factor 6; Deoxykanamycin B	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic
Tobramycin (Nebramycin Factor 6) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms .Tobramycin can be used to pneumonia research caused by Pseudomonas aeruginosa .

HY-N10431

Stigmane B	Zea mays L. Terpenoids Gramineae Source classification Diterpenoids Plants	Keap1-Nrf2
Stigmane B (Compound 2) is a *nuclear factor* E2-related factor (Nrf2) activator. Stigmane B downregulates apoptosis and reactive oxygen species (ROS)** generation, and increases antioxidant enzyme activities. Stigmane B shows neuroprotective effects .

HY-N11640

Methyl Ganoderic acid B	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Others
Methyl Ganoderic acid B is a triterpenoid, that can be isolated from Ganoderma lucidum. Methyl Ganoderic acid B has nerve growth factor-like neuronal survival-promoting effects .

HY-N12566

Erinacin B	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Others
Erinacin B is a active product that can be extracts from the mycelia of Hericium erinaceum. Erinacin B shows potent stimulating activity of nerve growth factor (NGF)-synthesis .

HY-N10009

Cudraflavone B	Structural Classification Brosimopsis oblongifolia Source classification Phenols Polyphenols Plants Moraceae	NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of *nuclear factor* κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1**. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells .

HY-126307

Urolithin B 3 Publications Verification	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields	NF-κB JNK ERK Akt AMPK Endogenous Metabolite
Urolithin B is one of Ellagitannins' slow microbial products, and has anti-inflammatory and anti-inflammatory effects. Urolithin B suppresses NF-κB activity. Urolithin B suppresses JNK, ERK and Akt's oxidation, and increases AMPK's oxidation. Urolithin B is also a quantitative change factor for bone and skin quality.

HY-B0441A

Tobramycin sulfate 5+ Cited Publications Nebramycin factor 6 sulfate; Deoxykanamycin B sulfate	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic
Tobramycin sulfate (Nebramycin Factor 6 sulfate) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms .

HY-N11920

Kadsurenin B	Structural Classification Source classification Lignans Piperaceae Phenylpropanoids Plants Piper kadsura (Choisy) Ohwi	Platelet-activating Factor Receptor (PAFR)
Kadsurenin B is a PAF (platelet-activating factor) antagonist with neuroprotective activity. Kadsurenin B has a wide range of pharmacological research potential, such as antibacterial, anti-inflammatory, neuroprotective, antioxidant, antiplatelet aggregation, cytotoxic, antiparasitic, etc .

HY-N10313

Dehydrobruceine B	Structural Classification Natural Products Microorganisms Source classification	Bcl-2 Family Keap1-Nrf2 Apoptosis
Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce apoptosis via mitochondrial method. Dehydrobruceine B increases *apoptosis-inducing factor* (AIF) and Bax expression and suppresses Keap1-Nrf2** .

HY-N3938

Gelsemiol	Structural Classification Iridoids Terpenoids Source classification Populus tomentosa Plants Salicaceae	Others
Gelsemiol is the main active ingredient in Verbena littoralis H. B. K.. Gelsemiol enhanced nerve growth factor (NGF) -induced axonal elongation in PC12D cells .

HY-N0784

Ginkgolide B 3 Publications Verification BN-52021	Structural Classification Classification of Application Fields Ginkgoaceae Terpenoids Source classification Diterpenoids Plants Endogenous metabolite Disease Research Fields Ginkgo biloba Cancer	Platelet-activating Factor Receptor (PAFR) Apoptosis
Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments .

HY-N4171

Dihydrocucurbitacin B	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	Apoptosis
Dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, inhibits nuclear factor of activated T cells (NFAT), induces cell cycle arrested in the G0 phase, and inhibits delayed type hypersensitivity .

HY-N8936

Narchinol B	Structural Classification Terpenoids Sesquiterpenes Source classification Nardostachys jatamansi (D. Don) DC. Plants Valerianaceae	Others
Narchinol B (Compound 4) is a sesquiter penoid compound. Narchinol B has anti-inflammatory effects. Narchinol B works by inhibiting proinflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as proinflammatory cytokines, such as interleukin-1b, IL-6, and tumor necrosis factor-α (TNF-α). Narchinol B significantly inhibits LPS-induced overproduction of NO in BV2 cells (IC₅₀=2.43 μM) .

HY-B1746

Pyridoxamine 5′-phosphate	Structural Classification Alkaloids Human Gut Microbiota Metabolites Neurological Disease Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Pyridoxamine 5′-phosphate is the active form of vitamin B6 bound to phosphoric acid. Pyridoxamine 5′-phosphate is the aminated form of pyridoxal 5'-phosphate hydrate (HY-W011727A) and as co-factor of a variety of enzymes central metabolite, potent antioxidant, vitamin B6 vitamer and enzyme substrate. Pyridoxamine 5′-phosphate can be interconverted with pyridoxal 5'-phosphate hydrate .

HY-N2056

11-Keto-beta-boswellic acid 11-Keto-β-boswellic acid	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Boswellia serrata Plants Burseraceae Disease Research Fields Cancer	Lipoxygenase Leukotriene Receptor NF-κB
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and *nuclear factor-kappa B (NF-κB)* activation and tumor necrosis factor alpha generation production .

HY-N1184

Tagitinin F	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Tithonia diversifolia A. Gray. Compositae	NF-κB
Tagitinin F is a sesquiterpene with potent anti-inflammatory properities and nuclear factor-kappa B inhibition. Tagitinin F inhibits ipopolysaccharide-induced myeloperoxidase activity in human neutrophils. Tagitinin F decreases the secretion of inflammatory products without inducing apoptosis in neutrophils .

HY-N2106

Dehydroevodiamine	Alkaloids Structural Classification Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Source classification Rutaceae Plants Inflammation/Immunology Disease Research Fields Indole Alkaloids	NF-κB COX PGE synthase NO Synthase
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes . Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells .

HY-N0527

Pentagalloylglucose Maximum Cited Publications 10 Publications Verification Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose	Infection Structural Classification other families Classification of Application Fields Anti-aging Source classification Phenols Polyphenols Plants Disease Research Fields	Parasite RABV
Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is a gallotannin isolated from various plants. It suppressed interleukin (IL)-4 induced signal pathway in B cell, and inhibited IgE production partially caused by increasing a population of Treg cells in conjunction with Treg-inducing factors. Pentagalloylglucose possesses significant anti-rabies virus (RABV) activity.

HY-N6769

Radicicol 3 Publications Verification Monorden	Structural Classification Antifungal Classification of Application Fields Source classification Marine natural products Anti-parasitic Disease Research Infection Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Disease Research Fields Marine microorganism	HSP Bacterial Antibiotic Parasite
Radicicol is an inhibitor of Hsp90 with an IC₅₀ value < 1 μM, and leads to proteasomal degradation . Radicicol exhibits inhibition on PDK with IC₅₀s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB . Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC₅₀ value of 16.04 μM .

HY-N0632

Esculentoside A 2 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Phytolacca acinosa Roxb. Plants Inflammation/Immunology Disease Research Fields Phytolaccaceae	COX NF-κB
Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta . Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models , has selective inhibitory activity towards cyclooxygenase-2 (COX-2) . Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways .

HY-N0787

Cryptochlorogenic acid 1 Publications Verification 4-Caffeoylquinic acid; 4-O-Caffeoylquinic acid	Structural Classification Classification of Application Fields Source classification Plants Moraceae Endogenous metabolite Simple Phenylpropanols Other Diseases Phenols Polyphenols Phenylpropanoids Disease Research Fields Morus alba Linn.	Endogenous Metabolite NF-κB Keap1-Nrf2 mTOR HIF/HIF Prolyl-Hydroxylase
Cryptochlorogenic acid (4-Caffeoylquinic acid) is a naturally occurring phenolic acid compound with oral effectiveness, anti-inflammatory, antioxidant and anti-cardiac hypertrophy effects. Alleviating LPS (HY-D1056) and ISO (HY-B0468) by regulating proinflammatory factor expression, inhibiting NF-κB activity, promoting Nrf2 nuclear transfer, and regulating PI3Kα/Akt/ mTOR / HIF-1α signaling pathway Induced physiological stress response .

HY-N9736

6,4'-Dihydroxy-7-methoxyflavanone	Structural Classification Flavonoids Dalbergia odorifera T. Chen Flavones Leguminosae Source classification Plants	Calcineurin
6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis .

Cat. No.	Product Name	Chemical Structure

HY-A0003S

Lenalidomide-d5

Lenalidomide-d₅ is deuterium labeled Lenalidomide. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells[1][2].

HY-A0003S2

Lenalidomide-13C5,15N

Lenalidomide- ¹³C₅, ¹⁵N is ¹⁵N and ¹³C labeled Lenalidomide (HY-A0003). Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83239

Complement factor B Antibody (YA2984)

C3/C5 convertase; Complement factor B; PBF2; Properdin factor B
WB Human
HY-P81497

Trefoil Factor 3 Antibody (YA1242)

hITF; hP1.B; InTinal trefoil factor; ITF; mITF; P1B; Polypeptide P1.B; TFF3; TFI; TREFOIL; Trefoil factor 3
IHC-P Human
HY-P82882

VEGFB Antibody (YA2627)

VEGFB; VRF; Vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VRF
WB Human, Mouse
HY-P81438

Nampt Antibody (YA1183)

Nicotinamide phosphoribosyltransferase; NAmPRTase; Nampt; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; Visfatin
IHC-P Human

HY-P81312

	*Transcription Initiation Factor* IIB Antibody (YA1054)** General transcription factor IIB; General transcription factor TFIIB; gtf2b; RNA polymerase II transcription factor IIB; S300 II; S300-II; TF IIB; TF2B; TF2B_HUMAN; TFIIB; Transcription initiation factor IIB.	WB	Human, Mouse, Monkey

HY-P81312A

	*Transcription Initiation Factor* IIB Antibody (YA1055)** General transcription factor IIB; General transcription factor TFIIB; gtf2b; RNA polymerase II transcription factor IIB; S300 II; S300-II; TF IIB; TF2B; TF2B_HUMAN; TFIIB; Transcription initiation factor IIB.	WB, IP	Human, Mouse, Rat

HY-P81811

	PDGF B Antibody (YA1556) PDGFB; PDGF2; SIS; Platelet-derived growth factor subunit B; PDGF subunit B; PDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Proto-oncogene c-Sis; Becaplermin	WB, IHC-P	Human, Mouse, Rat

HY-P81235

	IL-4 Antibody Interleukin-4; IL4; IL 4; B cell growth factor 1; B cell IgG differentiation factor; B Cell Stimulatory factor 1; BCGF 1; BCGF1; Binetrakin; BSF 1; BSF1; HCGF; Hodgkin’s Cell Growth factor; IA Inducing factor; IGG1 induction factor; Il4e12; Interleukin 4; Interleukin 4, isoform 1; Interleukin4; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MCGF2; MFF; MGC79402; Pitrakinra; T cell growth factor 2; TCGF2; IL4_MOUSE; B-cell stimulatory factor 1; BSF-1.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	IL-4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 14 kDa, targeting to IL-4. It can be used for WB、ELISA、IHC-P、IHC-F、IF assays with tag free, in the background of Transfected.

HY-P81410

MEF2B Antibody (YA1155)

MEF2B; XMEF2; Myocyte-specific enhancer factor 2B; RSRFR2; Serum response factor-like protein 2
IHC-P Human

HY-P81123

	OPG Antibody MGC29565; OCIF; OPG; Osteoclastogenesis Inhibitory factor; TNFRSF 11B; TNFRSF11B; TR 1; TR1; Tumor Necrosis factor Receptor Superfamily Member 11b; TR11B_HUMAN.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	OPG Antibody is an unconjugated, approximately 43 kDa, rabbit-derived, anti-OPG polyclonal antibody. OPG Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, and predicted: dog, cow background without labeling.

HY-P80722

	IL-4 Antibody (YA343) IL4; Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra	WB	Human, Mouse, Rat
	IL-4 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 17 kDa, targeting to IL-4. It can be used for WB assays with tag free, in the background of Transfected.

HY-P80764

	NF-KB p105 Antibody (YA700) NFKB1; Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	WB	Human, Mouse, Rat
	NF-KB p105 Antibody (YA700) is a non-conjugated and Mouse origined monoclonal antibody about 105 kDa, targeting to NF-KB p105 (5E3). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P81049

	Phospho-NFKB1(Ser337) Antibody NFKB1; NF-KB; Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Nuclear factor NF-kappa-B p50 subunit; NFkB p105 / p50; NFkB p105/p50; nuclear factor kappa B subunit 1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappabeta	WB, IHC-P, IHC-F, FC, ICC/IF, ELISA	Human, Mouse
	Phospho-NFKB1 p105/p50 (Ser337) Antibody is an unconjugated, approximately 50&120 kDa, rabbit-derived, anti-NFKB1 p105/p50 (Ser337) polyclonal antibody. Phospho-NFKB1 p105/p50 (Ser337) Antibody can be used for: WB, IHC-P, ICC/IF expriments in human, mouse, rat background without labeling.

HY-P81736

	APAF1 Antibody (YA1481) APAF; APAF-1; APAF1; apoptotic peptidase activating factor 1; apoptotic protease activating factor 1; Apoptotic protease-activating factor 1; CED4; DKFZp781B1145; KIAA0413	WB, IHC-P, ICC/IF	Human, Mouse

HY-P82107

Rel B Antibody (YA1852)

RELB; Transcription factor RelB; I-Rel
WB, IP Human, Mouse, Rat

HY-P80719

	IKK beta Antibody IKBKB; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB	WB, ICC/IF	Human, Mouse, Rat
	IKK beta Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 87 kDa, targeting to IKK beta. It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P82259

Elongation factor 1 gamma Antibody (YA2004)

EEF1G; EF1G; Elongation factor 1-gamma; EF-1-gamma; eEF-1B gamma
WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

HY-P82511

	SF3B1 Antibody (YA2256) SF3B1; SAP155; Splicing factor 3B subunit 1; Pre-mRNA-splicing factor SF3b 155 kDa subunit; SF3b155; Spliceosome-associated protein 155; SAP 155	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

HY-P80723

	IL-6 Antibody IL6; IFNB2; Interleukin-6; IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2	WB, IHC-P, ELISA	Human
	IL-6 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 24 kDa, targeting to IL-6. It can be used for WB,IHC-P,ELISA assays with tag free, in the background of Human.

HY-P81426

	SF3B3 Antibody (YA1171) SF3B3; KIAA0017; SAP130; Splicing factor 3B subunit 3; Pre-mRNA-splicing factor SF3b 130 kDa subunit; SF3b130; STAF130; Spliceosome-associated protein 130; SAP 130	IHC-P	Human

HY-P81121

	NGFB Antibody NGF; Beta nerve growth factor; NGF-beta; Beta nerve growth factor precursor; Beta NGF; HSAN5; MGC161426; MGC161428; Nerve growth factor beta; Nerve growth factor beta polypeptide; Nerve growth factor beta subunit; NGF B; NID67; NGF beta; NGF-B; NGF_HUMAN. NGF-β; NGF β; NGFβ; β NGF; β-NGF; .	ELISA, IHC-P, IHC-F, ICC/IF	Human, Rat, Dog
	NGFB Antibody is an unconjugated, approximately 13/32 kDa, rabbit-derived, anti-NGFB polyclonal antibody. NGFB Antibody can be used for: ELISA, IHC-P, IHC-F, ICC, IF expriments in human, rat, dog, and predicted: mouse, chicken, pig, cow, horse, rabbit background without labeling.

HY-P82467

BOB1 Antibody (YA2212)

BOB 1; BOB-1; OBF 1; OBF1; OCA B; OCA-B; OCAB; OCT binding factor 1; Pou2af1
WB, IHC-P, ICC/IF, FC Human

HY-P81475

	TCF3 / E2A Antibody (YA1220) TCF3; BHLHB21, E2A, ITF1; Transcription factor E2-alpha; Class B basic helix-loop-helix protein 21 (bHLHb21); Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; Transcription factor 3 (TCF-3); Transcription factor ITF-1	IHC-P	Human

HY-P82636

BMP15 Antibody (YA2381)

BMP15; GDF9B; Bone morphogenetic protein 15; BMP-15; Growth/differentiation factor 9B; GDF-9B
WB, FC Human, Mouse, Rat

HY-P80763

	NF-KB p100 Antibody NFKB2; LYT10; Nuclear factor NF-kappa-B p100 subunit; DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Oncogene Lyt-10; Lyt10	WB, ICC/IF, IP	Human, Mouse, Rat
	NF-KB p100 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 97 kDa, targeting to NF-KB p100. It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P83616

Factor H Antibody (YA3361)

AHUS1; AMBP1; ARMD4; ARMS1; beta1H; CFH; CFHL3; complement factor H; isoform b; factor H; factor H like 1; FHL1; HF1; HF2; HUS
WB, ICC/IF Human

HY-P83008

	IL-12 beta Antibody (YA2753) IL12B; NKSF2; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2	WB	Human

HY-P81243

	F2 Antibody Des-gamma-carboxy (abnormal)prothrombin; Des-Gamma-carboxy-prothrombin; coagulation factor II (thrombin); Coagulation factor II; DCP; factor II; Prepro coagulation factor II; Prothrombin; prothrombin B-chain; PT; RPRGL2; serine protease; THPH1; THRB; THRB_HUMAN; Thrombin heavy chain.	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat

HY-P83443

	SDF1 Antibody (YA3188) CXCL12; SDF1; SDF1A; SDF1B; Stromal cell-derived factor 1; SDF-1; hSDF-1; C-X-C motif chemokine 12; Intercrine reduced in hepatomas; IRH; hIRH; Pre-B cell growth-stimulating factor; PBSF	WB, ICC/IF	Human

HY-P83223

	NME2 Antibody (YA2968) NME2; NM23B; Nucleoside diphosphate kinase B; NDK B; NDP kinase B; C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB; nm23-H2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

HY-P81765

	BAFF Antibody (YA1510) TNFSF13B; BAFF; BLYS; TALL1; TNFSF20; ZTNF4; Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1; CD257	FC, ELISA	Human

HY-P82126

	IKK alpha/beta Antibody (YA1871) CHUK; IKKA; TCF16; Inhibitor of nuclear factor kappa-B kinase subunit alpha; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B	WB, ICC/IF, IP	Human, Mouse, Rat

HY-P82852

PAX5 Antibody (YA2597)

PAX5; Paired box protein Pax-5; B-cell-specific transcription factor; BSAP
WB, IHC-P, ICC/IF, FC Human, Mouse

HY-P83618

	Plasma Kallikrein Antibody (YA3363) Fletcher factor; kallikrein B plasma; Kallikrein B1; Kininogenin; KLK3; KLKB1; PKK; PKKD; Plasma kallikrein light chain; PPK; Prekallikrein	WB, IHC-P, IP	Human, Rat

HY-P82180

	PDGFR beta Antibody (YA1925) PDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-deri	WB, IP	Human, Mouse, Rat

HY-P81306

	SAFB1 Antibody (YA1042) SAFB; HAP; HET; SAFB1; Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding protein	WB, ICC/IF, ChIP	Human

HY-P81306A

	SAFB1 Antibody (YA1043) SAFB; HAP; HET; SAFB1; Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding protein	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse

HY-P83563

Ubiquitin Conjugation Factor E4 B Antibody (YA3308)

E4; UFD2; HDNB1; UBOX3; UFD2A
WB, ICC/IF Human, Rat
HY-P81420

GRB7 Antibody (YA1165)

B47; Epidermal growth factor receptor GRB 7; GRB7 adapter protein; GRB7
IHC-P Human

HY-P81866

	IKK epsilon Antibody (YA1611) IKBKE; IKKE; IKKI; KIAA0151; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; Inducible I kappa-B kinase; IKK-i	WB, IHC-P, ICC/IF, FC	Human

HY-P83317

	Phospho-PDGFR beta (Tyr740) Antibody (YA3062) PDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-deri	WB, ICC/IF	Mouse, Rat

HY-P83064

Transcription Factor 4 Antibody (YA2809)

E2-2; ITF2; PTHS; SEF2; ITF-2; SEF-2; TCF-4; SEF2-1; SEF2-1A; SEF2-1B; bHLHb19
WB, IHC-P, FC, ChIP Human
HY-P81756

BCMA Antibody (YA1501)

TNFRSF17; BCM; BCMA; Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269
FC, ELISA Human

HY-P80936

	YB1 Antibody YBX1; NSEP1; YB1; Nuclease-sensitive element-binding protein 1; CCAAT-binding transcription factor I subunit A; CBF-A; DNA-binding protein B; DBPB; Enhancer factor I subunit A; EFI-A; Y-box transcription factor; Y-box-binding protein 1; YB-	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	YB1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 36 kDa, targeting to YB1. It can be used for WB,IHC-P,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P81124

	RANKL/CD254 Antibody OPGL; CD254; hRANKL2; ODF; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL; Receptor activator of nuclear factor kappa B ligand; sOdf; SOFA; TNF related activation induced cytokine; TNFSF 11; TNFSF11; TRANCE; Tumor necrosis factor ligand superfamily member 11; Osteoprotegerin Ligand; TNF11_HUMAN.	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse
	RANKL/CD254 Antibody is an unconjugated, approximately 35 kDa, rabbit-derived, anti-RANKL/CD254 polyclonal antibody. RANKL/CD254 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, and predicted: rat, dog background without labeling.

HY-P82727

NR5A2 Antibody (YA2472)

B1-binding factor; B1F2; CPF; CYP7A promoter-binding factor; FTF; FTZ F1; FTZ F1beta; FTZ-F1; FTZ-F1beta; hB1F 2; hB1F-2; LRH1; Nr5a2
WB Human, Mouse, Rat

HY-P81184

	CD80 Antibody (YA3386) Activation B7-1 antigen; B lymphocyte activation antigen B7; B7; B7-1; B7-1 antigen; BB1; CD28 antigen ligand 1; CD28LG; CD28LG1; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 antigen; CD80 molecule; CD80_HUMAN; Costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; LAB7; T-lymphocyte activation antigen CD80; CD80_RAT.	WB, IHC-P, FC, ICC/IF	Human, Mouse
	CD80 Antibody is an unconjugated, approximately 30 kDa, mouse-derived, anti-CD80 monoclonal antibody. CD80 Antibody can be used for: WB, IHC-P,FC ICC expriments in mouse,human, and predicted: rat background without labeling.

HY-P81840

	Peroxiredoxin 2 Antibody (YA1585) PRDX2; NKEFB; TDPX1; Peroxiredoxin-2; Natural killer cell-enhancing factor B; NKEF-B; PRP; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1	WB, IHC-P	Human, Mouse, Rat

HY-P81239

	Phospho-NF-κB p65 (Ser276) Antibody NF-kB p65 (phospho S276); p-NF-kB p65 (phospho S276); RELA(phospho S276); NF kB P65; NF-kB p65; NF kB P65; NF-κBp65; p65 NF kappaB; p65 NFkB; RELA; Transcription factor p65; v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)); V Rel Avian Reticuloendotheliosis Viral Oncogene Homolog A; v rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A; p65NFKB; Avian reticuloendotheliosis viral (v rel) oncogene homolog A; MGC131774; NFKB 3; NFKB3; Nuclear factor NF Kappa B p65 Subunit; Nuclear factor of kappa light polypeptide gene enhancer in B cells 3; Nuclear factor Of Kappa Light Polypeptide Gene Enhancer In B Cells. NFκB-p65; NFκB p65; NF κB-p65; NFκBp65	ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat,

HY-P83496

	SMARCA2 Antibody (YA3241) SMARCA2; BAF190B; BRM; SNF2A; SNF2L2; Probable global transcription activator SNF2L2; ATP-dependent helicase SMARCA2; BRG1-associated factor 190B; BAF190B; Protein brahma homolog; hBRM; SNF2-alpha; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2	WB, IHC-F, IHC-P, ICC/IF	Human

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