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Results for "

steroid-receptor

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

2

Peptides

1

Natural
Products

2

Isotope-Labeled Compounds

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-107917
    Desoxycorticosterone pivalate

    DOCP

    		 Mineralocorticoid Receptor Endocrinology
    Desoxycorticosterone pivalate (DOCP) is a mineralocorticoid hormone and an analog of Desoxycorticosterone. Desoxycorticosterone pivalate is used for the management of canine hypoadrenocorticism .
    Desoxycorticosterone pivalate
  • HY-B0154
    Fluticasone (propionate)
    1 Publications Verification

    		 Glucocorticoid Receptor Enterovirus Endogenous Metabolite ADC Cytotoxin Infection Inflammation/Immunology Endocrinology
    Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .
    Fluticasone (propionate)
  • HY-W739985
    7α-(Thiomethyl)spironolactone

    7α-Thiomethylspironolactone

    		 Others Infection
    7α-(Thiomethyl)spironolactone is a nuclear steroid receptor antagonist that can be used for the research of coronaviruses .
    7α-(Thiomethyl)spironolactone
  • HY-121582
    (E)-SI-2

    (E)-EPH 116

    		 Others Cancer
    (E)-SI-2 is an isomer of SI-2, an inhibitor of the steroid receptor coactivator SRC-3. SI-2 has anticancer activity and increases the number of cytotoxic immune cells in mice with breast cancer .
    (E)-SI-2
  • HY-163469
    SRC-3-IN-2

    		Others Cancer
    SRC-3-IN-2 (SI-12 6c)is an orally active steroid receptor coactivator 3 (SRC-3) inhibitor. SRC-3-IN-2 has antitumor activity .
    SRC-3-IN-2
  • HY-B0154S
    Fluticasone propionate-d3

    		Glucocorticoid Receptor Enterovirus Endogenous Metabolite Infection Inflammation/Immunology Endocrinology
    Fluticasone propionate-d3 is the deuterium labeled Fluticasone propionate. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity[1][2].
    Fluticasone propionate-d3
  • HY-B0154S1
    Fluticasone propionate-d5

    		Isotope-Labeled Compounds Glucocorticoid Receptor Enterovirus Endogenous Metabolite Infection Inflammation/Immunology Endocrinology
    Fluticasone propionate-d5 is deuterium labeled Fluticasone (propionate). Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity[1][2].
    Fluticasone propionate-d5
  • HY-156530
    CYP11A1-IN-1

    		Cytochrome P450 Endocrinology
    CYP11A1-IN-1 (compound 30) is an inhibitor of CYP11A1, with IC50 value of 201-2000 nM. CYP11A1-IN-1 can be used for research in steroid receptor, particularly androgen receptor, dependent diseases and conditions, such as prostate cancer .
    CYP11A1-IN-1
  • HY-19625A
    (E/Z)-MCB-613

    		Reactive Oxygen Species Cancer
    (E/Z)-MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator. (E/Z)-MCB-613 overstimulates SRC activity in cancer cells resulting in excessive generation of reactive oxygen species (ROS), leading to cell stress and death by a process called paraptosis. (E/Z)-MCB-613 is a cytotoxic molecule that plays an important role in cancer .
    (E/Z)-MCB-613
  • HY-163468
    SRC-3-IN-1

    		Src Cancer
    SRC-3-IN-1(compound SI-10) is a steroid receptor coactivator 3 (SRC-3) inhibitor(IC50=3.3 μM). SRC-3-IN-1 has good water solubility, oral bioavailability, and improved selectivity profile. SRC-3-IN-1 can be used in prostate cancer research .
    SRC-3-IN-1
  • HY-19625
    MCB-613

    		Reactive Oxygen Species Cancer
    MCB-613 is a potent Steroid receptor coactivator SRC small molecule ‘stimulator’ (SMS), super-stimulates SRCs’ transcriptional activity. MCB-613 increases SRCs’ interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). MCB-613 is a SMS that target oncogenes can be exploited as anti-cancer agents by over-stimulating the SRC oncogenic program .
    MCB-613
  • HY-101447
    SI-2

    EPH 116

    		 Src Apoptosis Cancer
    SI-2 (EPH 116) is an inhibitor for steroid receptor coactivator-3 (SRC-3), which reduces the transcriptional activity and protein concentration of SRC-3 in cells, exhibits cytotoxicity in cancer cell, with IC50s ranging from 3-20 nM, inhibits migration of MDA-MB-468, induces apoptosis of MDA-MB-468. SI-2 inhibits the tumor growth in mouse models, without significant toxicity for heart and other major organs (20 mg/kg) .
    SI-2
  • HY-116028
    15-deoxy-Δ12,14-Prostaglandin D2

    15-Deoxy-Δ12,14-PGD2

    		 Endogenous Metabolite Cardiovascular Disease
    15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2. It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki=50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50=8 nM). It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 μM.1 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50=0.3 μg/mL). It inhibits ADP-induced platelet aggregation (IC50=320 ng/ml) less potently than PGD2.
    15-deoxy-Δ12,14-Prostaglandin D2

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