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  4. Sulfadoxine-d3

Sulfadoxine-d3  (Synonyms: Sulphadoxine d3)

Cat. No.: HY-B0439S1 Purity: ≥98.0%
COA Handling Instructions

Molarity Calculator

Sulfadoxine-d3 is a deuterium labeled Sulfadoxine (HY-B0439). Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine (HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections[1][2][3][4].

For research use only. We do not sell to patients.

Sulfadoxine-d<sub>3</sub> Chemical Structure

Sulfadoxine-d3 Chemical Structure

CAS No. : 1262770-70-6

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5 mg USD 210 In-stock
10 mg USD 350 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Sulfadoxine-d3:

Sulfadoxine-d3 Related Antibodies

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  • Biological Activity

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Description

Sulfadoxine-d3 is a deuterium labeled Sulfadoxine (HY-B0439). Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine (HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections[1][2][3][4].

IC50 & Target

Plasmodium

 

In Vitro

Sulfadoxine (0-100 μM; 7 d) has no impact on HIV-1 replication in MT-2 cells[4].
Sulfadoxine (100 μM; 48 h) has no impact on induction of S-phase accumulation in MT-2 cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfadoxine-d3 Related Antibodies
In Vivo

Sulfadoxine (0.1, 0.3, 10 mg/kg/d; p.o.; once daily for 3 d) in combination with azithromycin (30 mg/kg/d; p.o.; once daily for 3 d) shows efficacy against blood stage parasites or Plasmodium yoelii sporozoite in a mouse malaria model[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

313.35

Formula

C12H11D3N4O4S
CAS No.
Unlabeled Cas

2447-57-6
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(N)C=C1)(NC2=NC=NC(OC([2H])([2H])[2H])=C2OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (319.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.1 mg/mL (0.32 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1913 mL 15.9566 mL 31.9132 mL
5 mM 0.6383 mL 3.1913 mL 6.3826 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1913 mL 15.9566 mL 31.9132 mL 79.7830 mL
5 mM 0.6383 mL 3.1913 mL 6.3826 mL 15.9566 mL
10 mM 0.3191 mL 1.5957 mL 3.1913 mL 7.9783 mL
15 mM 0.2128 mL 1.0638 mL 2.1275 mL 5.3189 mL
20 mM 0.1596 mL 0.7978 mL 1.5957 mL 3.9891 mL
25 mM 0.1277 mL 0.6383 mL 1.2765 mL 3.1913 mL
30 mM 0.1064 mL 0.5319 mL 1.0638 mL 2.6594 mL
40 mM 0.0798 mL 0.3989 mL 0.7978 mL 1.9946 mL
50 mM 0.0638 mL 0.3191 mL 0.6383 mL 1.5957 mL
60 mM 0.0532 mL 0.2659 mL 0.5319 mL 1.3297 mL
80 mM 0.0399 mL 0.1995 mL 0.3989 mL 0.9973 mL
100 mM 0.0319 mL 0.1596 mL 0.3191 mL 0.7978 mL
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Sulfadoxine-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfadoxine-d31262770-70-6Sulphadoxine d3ParasiteAntibioticInhibitorinhibitorinhibit

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