2. Apoptosis
  3. Apoptosis
  4. TACC3 inhibitor 1

TACC3 inhibitor 1 is a potent and cross the blood-brain barrier TACC3 inhibitor. TACC3 inhibitor 1 induces Apoptosis and cell cycle arrest at G2/M phase. TACC3 inhibitor 1 induces the generation of intracellular ROS. TACC3 inhibitor 1 shows antiproliferative and anti-tumor activity.

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TACC3 inhibitor 1 Chemical Structure

TACC3 inhibitor 1 Chemical Structure

CAS No. : 3033646-06-6

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TACC3 inhibitor 1 Related Antibodies

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Description

TACC3 inhibitor 1 is a potent and cross the blood-brain barrier TACC3 inhibitor. TACC3 inhibitor 1 induces Apoptosis and cell cycle arrest at G2/M phase. TACC3 inhibitor 1 induces the generation of intracellular ROS. TACC3 inhibitor 1 shows antiproliferative and anti-tumor activity[1].

In Vitro

TACC3 inhibitor 1 (compound 7g) (1, 2, 4 µM; 36 h) induces apoptosis and cell cycle arrest at G2/M phase[1].
TACC3 inhibitor 1 (1, 2, 4 µM; 36 h) decreases the mitochondrial membrane potential and induces the generation of intracellular ROS[1].
TACC3 inhibitor 1 (1, 2, 4 µM; 24 h) inhibits cell migration and invasion in U87 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TACC3 inhibitor 1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: U251, U87, MDA-MB-231, JIMT-1, SKOV-3, HLF-1 cells
Concentration: 0-100 µM
Incubation Time: 24 h
Result: Showed antiproliferative activities with IC50s of 5.61, 3.29, 6.46, 4.84, 8.21, 23.11 µM for U251, U87, MDA-MB-231, JIMT-1, SKOV-3, HLF-1 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: U87 cells
Concentration: 1, 2, 4 µM
Incubation Time: 36 h
Result: Induced cell cycle arrest at G2/M phase with the 41.2% cells at G2/M phase at 4 µM.

Apoptosis Analysis[1]

Cell Line: U87 cells
Concentration: 1, 2, 4 µM
Incubation Time: 36 h
Result: Induced apoptosis in a dose-dependent manner with the percentage of early apoptotic cells increased from 4.49% in control group to 21.42%, late apoptotic cells increased from 0.52% to 26.72% at 4 µM.
In Vivo

TACC3 inhibitor 1 (20 mg/kg; i.p.; daily for 20 days) shows anti-tumor activity in mouse[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old BALB/c nude mice (U87 xenograft model)[1]
Dosage: 20 mg/kg
Administration: I.p.; daily for 20 days
Result: Exhibited a significant tumor growth regression and no observable toxicity during the administration period and had no effects on the body weight.
Molecular Weight

379.48

Formula

C20H21N5OS
CAS No.
Unlabeled CAS

SMILES

OC1CC2CC1CN2C3=CC=NC(NCC4=CSC(C5=CC=CC=C5)=N4)=N3
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Purity & Documentation
References
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TACC3 inhibitor 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TACC3 inhibitor 13033646-06-6Apoptosiscross the blood-brain barrierantiproliferativeanti-tumorapoptosisG2/M phasemigrationinvasionU87 cellsInhibitorinhibitorinhibit

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