2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. TCO-PEG3-Biotin

TCO-PEG3-Biotin is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). TCO-PEG3-Biotin is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

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TCO-PEG3-Biotin Chemical Structure

TCO-PEG3-Biotin Chemical Structure

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5 mg USD 255 In-stock
10 mg USD 410 In-stock
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Based on 1 publication(s) in Google Scholar

TCO-PEG3-Biotin Related Antibodies

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Description

TCO-PEG3-Biotin is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. TCO-PEG3-Biotin is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

IC50 & Target

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TCO-PEG3-Biotin Related Antibodies
Molecular Weight

570.74

Formula

C27H46N4O7S
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCOCCOCCOCCNC(CCCC[C@@H]1SC[C@H](N2)[C@@H]1NC2=O)=O)O[C@H]3CCC/C([H])=C/CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (219.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7521 mL 8.7606 mL 17.5211 mL
5 mM 0.3504 mL 1.7521 mL 3.5042 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7521 mL 8.7606 mL 17.5211 mL 43.8028 mL
5 mM 0.3504 mL 1.7521 mL 3.5042 mL 8.7606 mL
10 mM 0.1752 mL 0.8761 mL 1.7521 mL 4.3803 mL
15 mM 0.1168 mL 0.5840 mL 1.1681 mL 2.9202 mL
20 mM 0.0876 mL 0.4380 mL 0.8761 mL 2.1901 mL
25 mM 0.0701 mL 0.3504 mL 0.7008 mL 1.7521 mL
30 mM 0.0584 mL 0.2920 mL 0.5840 mL 1.4601 mL
40 mM 0.0438 mL 0.2190 mL 0.4380 mL 1.0951 mL
50 mM 0.0350 mL 0.1752 mL 0.3504 mL 0.8761 mL
60 mM 0.0292 mL 0.1460 mL 0.2920 mL 0.7300 mL
80 mM 0.0219 mL 0.1095 mL 0.2190 mL 0.5475 mL
100 mM 0.0175 mL 0.0876 mL 0.1752 mL 0.4380 mL
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TCO-PEG3-Biotin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCO-PEG3-BiotinADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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