2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. TNKS-2-IN-2

TNKS-2-IN-2 is a potent and selective inhibitor of TNKS2 with an IC50 of 22 nM.

For research use only. We do not sell to patients.

TNKS-2-IN-2 Chemical Structure

TNKS-2-IN-2 Chemical Structure

CAS No. : 2719726-91-5

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5 mg USD 480 In-stock
10 mg USD 680 In-stock
25 mg USD 1100 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

TNKS-2-IN-2 is a potent and selective inhibitor of TNKS2 with an IC50 of 22 nM[1].

Molecular Weight

473.48

Formula

C26H23N3O6
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

COC1=C(C(OC)=CC(C(NC2=CC=C(C=C2)NC(C3=CNC4=CC=CC=C4C3=O)=O)=O)=C1)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (264.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1120 mL 10.5601 mL 21.1202 mL
5 mM 0.4224 mL 2.1120 mL 4.2240 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1120 mL 10.5601 mL 21.1202 mL 52.8005 mL
5 mM 0.4224 mL 2.1120 mL 4.2240 mL 10.5601 mL
10 mM 0.2112 mL 1.0560 mL 2.1120 mL 5.2801 mL
15 mM 0.1408 mL 0.7040 mL 1.4080 mL 3.5200 mL
20 mM 0.1056 mL 0.5280 mL 1.0560 mL 2.6400 mL
25 mM 0.0845 mL 0.4224 mL 0.8448 mL 2.1120 mL
30 mM 0.0704 mL 0.3520 mL 0.7040 mL 1.7600 mL
40 mM 0.0528 mL 0.2640 mL 0.5280 mL 1.3200 mL
50 mM 0.0422 mL 0.2112 mL 0.4224 mL 1.0560 mL
60 mM 0.0352 mL 0.1760 mL 0.3520 mL 0.8800 mL
80 mM 0.0264 mL 0.1320 mL 0.2640 mL 0.6600 mL
100 mM 0.0211 mL 0.1056 mL 0.2112 mL 0.5280 mL
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TNKS-2-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNKS-2-IN-22719726-91-5PARPpoly ADP ribose polymeraseTNKS2 InhibitorFlavonoids and quinolone derivativesMolecular dockingInhibitorinhibitorinhibit

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