2. Cell Cycle/DNA Damage Epigenetics Autophagy Anti-infection Neuronal Signaling Stem Cell/Wnt Metabolic Enzyme/Protease
  3. HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite
  4. Valproic acid-d4

Valproic acid-d4  (Synonyms: VPA-d4; 2-Propylpentanoic Acid-d4)

Cat. No.: HY-10585S Purity: ≥98.0%
COA Handling Instructions

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Valproic acid-d4 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].

For research use only. We do not sell to patients.

Valproic acid-d<sub>4</sub> Chemical Structure

Valproic acid-d4 Chemical Structure

CAS No. : 87745-17-3

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1 mg USD 330 In-stock
5 mg USD 920 In-stock
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Based on 1 publication(s) in Google Scholar

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Valproic acid-d4 Related Antibodies

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Description

Valproic acid-d4 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Valproic acid-d4 Related Antibodies
Molecular Weight

148.24

Formula

C8H12D4O2
CAS No.
Unlabeled CAS

99-66-1
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCC([2H])([2H])C(C(O)=O)C([2H])([2H])CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (674.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7458 mL 33.7291 mL 67.4582 mL
5 mM 1.3492 mL 6.7458 mL 13.4916 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.7458 mL 33.7291 mL 67.4582 mL 168.6454 mL
5 mM 1.3492 mL 6.7458 mL 13.4916 mL 33.7291 mL
10 mM 0.6746 mL 3.3729 mL 6.7458 mL 16.8645 mL
15 mM 0.4497 mL 2.2486 mL 4.4972 mL 11.2430 mL
20 mM 0.3373 mL 1.6865 mL 3.3729 mL 8.4323 mL
25 mM 0.2698 mL 1.3492 mL 2.6983 mL 6.7458 mL
30 mM 0.2249 mL 1.1243 mL 2.2486 mL 5.6215 mL
40 mM 0.1686 mL 0.8432 mL 1.6865 mL 4.2161 mL
50 mM 0.1349 mL 0.6746 mL 1.3492 mL 3.3729 mL
60 mM 0.1124 mL 0.5622 mL 1.1243 mL 2.8108 mL
80 mM 0.0843 mL 0.4216 mL 0.8432 mL 2.1081 mL
100 mM 0.0675 mL 0.3373 mL 0.6746 mL 1.6865 mL
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Valproic acid-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valproic acid-d487745-17-3VPA-d42-Propylpentanoic Acid-d4HDACAutophagyMitophagyHIVNotchEndogenous MetaboliteHistone deacetylasesMitochondrial AutophagyHuman immunodeficiency virusInhibitorinhibitorinhibit

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