Publications Using MCE Products

Patent: US 2014/0309249 AI Patent: US 2014/0309279 A1 PLoS One. 9(10):e110453. (2014). Patent:US 2014/0303235 Al Animal Feed Science and Technology.DOI: 10.1016/j.anifeedsci. (2014). Biomed Chromatogr. (2014). J Steroid Biochem Mol Biol. pii: S0960-0760(14)00203-9. (2014). J Cell Physiol. doi: 10.1002/jcp.24835. (2014). Science. 346(6205):1255784. (2014). J Med Chem. (2014). Biochem Biophys Res Commun. pii: S0006-291X(14)01696-9. (2014). J Virol. 88(20):11872-85. (2014). J Physiol. (2014). Antiviral Res. pii: S0166-3542(14)00255-1. (2014). Clin Cancer Res. pii: clincanres.0902. (2014). Br J Pharmacol. doi: 10.1111/bph.12889. (2014). Acta Neuropathol Commun. 2(1):98. (2014). Blood Cancer J. 4:e240.(2014). Neurobiol Dis. DOI: 10.1016/j.nbd.2014.08.005. (2014). J Virol. pii: JVI.01867-14. (2014). Chem Biol.18(6):679-80.(2011) Leukemia. doi: 10.1038/leu. (2014) Nat Med. doi: 10.1038/nm.3610 (2014). Nature. doi: 10.1038/nature13485 (2014). Arch Virol. (2014). Spectrochim Acta A Mol Biomol Spectrosc.131:347-54 (2014). Cell Death Dis. 5:e1338.(2014). PLoS One. 9(7):e100985. (2014). Environ Toxicol Pharmacol. (2014). Stem Cell Research (2014). Antimicrob Agents Chemother. pii: AAC.03534-14 (2014). BioMed Research International. (2014). Chem Biol Drug Des. (2014). Sci Rep. 4:5411 (2014). PLoS One. 9(6):e99083 (2014). Chem Res Toxicol.27(6):949-51 (2014). Biochem Biophys Res Commun. pii: S0006-291X(14)00930-9 (2014). DNA Repair (Amst).pii: S1568-7864(14)00121-9 (2014). ACS Nano.8(6):5468-77 (2014). Biomaterials. pii: S0142-9612(14)00440-2 (2014). Eur Urol. pii: S0302-2838(14)00396-0 (2014). Spectrochim Acta A Mol Biomol Spectrosc.131:347-54 (2014). Virology.456-457:300-9 (2014). Trends Pharmacol Sci. pii: S0165-6147(14)00017-0 (2014). Mol Pain.10(1):10 (2014). Ann Hematol.(2014). Biopolymers.101(4):391-7 (2014). BMC Musculoskelet Disord. 15(1):18 (2014). PLoS One. 9(1):e85780 (2014). Cancer Res. 74(1):15-23 (2014). Am J Physiol Lung Cell Mol Physiol.306(2):L207-15 ( 2014). ACS Nano. 24;8(6):5468-77(2014). Pharmacology 85, 365-371 (2010). Cancer research 73, 5206-5217 (2013). Clinical Cancer Research 19, 598-609 (2013). Cancer research 73, 2574-2586 (2013). J Pharm Biomed Anal. 66:232-9.66, 232-239 (2012). Journal of Alzheimer's Disease 21, 1005-1012 (2010). Journal of bioenergetics and biomembranes 44, 155-161 (2012). International immunopharmacology 15, 38-41 (2013). Current Biology 23, 1514-1526 (2013). European journal of pharmacology 663, 74-79 (2011). Cancer research 73, 2574-2586 (2013). Science translational medicine 5, 196ra199-196ra199 (2013). PloS one 8, e56473 (2013). Hypertension 60, 1207-1212 (2012). American Journal of Physiology-Heart and Circulatory Physiology 299, H1309-H1317 (2010). European journal of nuclear medicine and molecular imaging 40, 1739-1747 (2013). J Pharm Pharmacol. 66(4):574-83 (2014). Antiviral Res. 99(1):6-11 (2013). Nat Cell Biol.14(3):295-303 (2012). BMC Biol.8; 11:78 (2013). Biopolymers. 101(4):391-7 (2014).

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  • 32 New Products Within 30 Days

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  • 7ACC1
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  • PathWay: Membrane Transporter/Ion Channel

    Target: MCT

    7ACC1(DEAC; Coumarin D 1421; D 1421) selectively interfere with lactate fluxes in the lactate-rich tumor microenvironment; inhibits lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters.

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  • PTP1B-IN-1
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  • PathWay: Others

    Target: Others

    PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 1.6 mM; 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis.

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  • G007-LK
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  • PathWay: Cell Cycle/DNA Damage

    Target: PARP

    G007-LK displays high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice.

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  • DGAT1-IN-1
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  • PathWay: Metabolism/Protease

    Target: DGAT

    DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM(cell lysate from Hep3B cells overexpressing human DGAT1).

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