1. Search Result
Search Result
Pathways Recommended: PI3K/Akt/mTOR
No matches for "

3,3(acute)-Diindolylmethane

" within the MedChemExpress (MCE) catalog. Here are the results you might be looking for.

54

Inhibitors & Agonists

1

Fluorescent Dye

10

Peptides

1

Inhibitory Antibodies

35

Recombinant Proteins

4

Isotope-Labeled Compounds

5

Antibodies

1

Click Chemistry

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-124871

    Arenavirus Infection
    LASV inhibitor 3.3 is a Lassa fever virus (LASV) inhibitor. LASV inhibitor 3.3 binds with LASV glycoprotein (GP) and promotes virus membrane fusion and infection. LASV inhibitor 3.3 can be used for LASV infection research .
    LASV inhibitor <em>3.3</em>
  • HY-123966A

    Phosphatase Neurological Disease
    MY33-3 hydrochloride is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM. MY33-3 hydrochloride also inhibits PTP-1B (IC50 ~0.7 μM). MY33-3 hydrochloride can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction [3].
    MY<em>33</em>-<em>3</em> hydrochloride
  • HY-123966

    Phosphatase
    MY33-3 is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM. MY33-3 also inhibits PTP-1B (IC50 ~0.7 μM). MY33-3 can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction [3].
    MY<em>33</em>-<em>3</em>
  • HY-P2625
    GLP-2(3-33)
    1 Publications Verification

    GCGR Metabolic Disease
    GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC50=5.8 nM) .
    GLP-2(<em>3</em>-<em>33</em>)
  • HY-P5576

    Antibiotic Bacterial Infection Cancer
    Aurein 3.3 is an antibiotic antimicrobial peptide. Aurein 3.3 also has anticancer activity .
    Aurein <em>3.3</em>
  • HY-147898

    PI3K Apoptosis Cancer
    PI3K-IN-33 (Compound 6e) is a highly selective PI3K inhibitor with IC50 values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-33 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-33 can be used in leukemia research .
    PI<em>3</em>K-IN-<em>33</em>
  • HY-RI04356

    MicroRNA
    rno-miR-33-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    rno-miR-33-3p inhibitor
    rno-miR-33-3p inhibitor
  • HY-RI04356A

    MicroRNA
    rno-miR-33-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    rno-miR-33-3p antagomir
    rno-miR-33-3p antagomir
  • HY-R04356

    MicroRNA Cancer
    rno-miR-33-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    rno-miR-33-3p mimic
    rno-miR-33-3p mimic
  • HY-R04356A

    MicroRNA
    rno-miR-33-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    rno-miR-33-3p agomir
    rno-miR-33-3p agomir
  • HY-RI00702A

    MicroRNA
    hsa-miR-33a-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-33a-3p antagomir
    hsa-miR-33a-3p antagomir
  • HY-RI00704A

    MicroRNA
    hsa-miR-33b-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-33b-3p antagomir
    hsa-miR-33b-3p antagomir
  • HY-R00702

    MicroRNA Cancer
    hsa-miR-33a-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    hsa-miR-33a-3p mimic
    hsa-miR-33a-3p mimic
  • HY-R00704

    MicroRNA Cancer
    hsa-miR-33b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    hsa-miR-33b-3p mimic
    hsa-miR-33b-3p mimic
  • HY-R00702A

    MicroRNA
    hsa-miR-33a-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-33a-3p agomir
    hsa-miR-33a-3p agomir
  • HY-R00704A

    MicroRNA
    hsa-miR-33b-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-33b-3p agomir
    hsa-miR-33b-3p agomir
  • HY-RI00702

    MicroRNA
    hsa-miR-33a-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    hsa-miR-33a-3p inhibitor
    hsa-miR-33a-3p inhibitor
  • HY-RI00704

    MicroRNA
    hsa-miR-33b-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    hsa-miR-33b-3p inhibitor
    hsa-miR-33b-3p inhibitor
  • HY-128812A

    E3 ligase Ligand-Linker Conjugates 33 Hydrochloride

    E3 Ligase Ligand-Linker Conjugates Cancer
    cIAP1 Ligand-Linker Conjugates 11 Hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 11 Hydrochloride can be used to design SNIPERs .
    cIAP1 Ligand-Linker Conjugates 11 Hydrochloride
  • HY-128812

    E3 ligase Ligand-Linker Conjugates 33

    E3 Ligase Ligand-Linker Conjugates Cancer
    cIAP1 Ligand-Linker Conjugates 11 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 11 can be used to design SNIPERs .
    cIAP1 Ligand-Linker Conjugates 11
  • HY-P2625S

    Isotope-Labeled Compounds Metabolic Disease
    GLP-2(3-33) (Leu- 13C6, 15N) is 13C and 15N labeled GLP-2(3-33) (HY-P2625). GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC50=5.8 nM).
    GLP-2(<em>3</em>-<em>33</em>) (Leu-13C6,15N)
  • HY-108370

    N3-TEG-COOH; 14-Azido-3,6,9,12-tetraoxatetradecanoic acid

    PROTAC Linkers Cancer
    N33-TEG-COOH (N3-TEG-COOH) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . N33-TEG-COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    N<em>33</em>-TEG-COOH
  • HY-P2625S1

    Isotope-Labeled Compounds Metabolic Disease
    GLP-2(3-33) (Leu- 13C6, 15N) TFA is 13C and 15N labeled GLP-2(3-33) (HY-P2625). GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC50=5.8 nM).
    GLP-2(<em>3</em>-<em>33</em>) (Leu-13C6,15N) (TFA)
  • HY-147919

    Fungal Infection
    Antifungal agent 33 (compound 4e) is a potent antifungal agent. Antifungal agent 33 exhibits remarkable antifungal activity against C. albicans, with a MIC of 16 μg/mL. Antifungal agent 33 shows potent inhibitory activity against Lanosterol 14α-demethylase (CYP51), with an IC50 of 0.19 μg/mL .
    Antifungal agent <em>33</em>
  • HY-139749

    Bacterial Cancer
    Antibacterial agent 33, an antibacterial agent, significantly lowers MIC value of antibacterial agent Ceftazidime .
    Antibacterial agent <em>33</em>
  • HY-115947

    Others Cancer
    Anticancer agent 33 (compound 3), a Squamocin and Bullatacin derivative, is a potent anticancer agent. Anticancer agent 33 shows high potency to inhibit 4T1 breast cancer cell line (A549, HeLa, HepG2 and MCF-7 cells) growth with IC50s of 1.9-5.4 µM .
    Anticancer agent <em>33</em>
  • HY-149900

    Biochemical Assay Reagents Infection
    Antiviral agent 33 (compound 1c) is a double-stranded DNA (dsDNA) virus inhibitor with IC50 values of 0.0790 and 0.1572 µM for VACV and AdV5, respectively. Antiviral agent 33 also has potential for oral administration .
    Antiviral agent <em>33</em>
  • HY-149856

    Microtubule/Tubulin Apoptosis Cancer
    Tubulin inhibitor 33, a tubulin polymerization inhibitor, inhibits tubulin polymerization in a dose-dependent manner with an IC50 of 9.05 μM. Tubulin inhibitor 33 has antitumor effects and induces cell apoptosis that can be used for antitumor research .
    Tubulin inhibitor <em>33</em>
  • HY-D2095

    Fluorescent Dye Cancer
    Medical fluorophore 33 is a novel quinoline-isoquinoline salt. Medical fluorophore 33 exhibits a strong fluorescent signal, good microsomal stability and high biocompatibility in vivo. Medical fluorophore 33 has antitumor activity in colorectal cancer mice .
    Medical fluorophore <em>33</em>
  • HY-155354

    Parasite Infection
    Antimalarial agent 33 (compound 5g) has antiplasmodial activity against erythrocytic and hepatic stages of Plasmodium with an EC50 of 1.1 μM for K1 P. falciparum strain. Antimalarial agent 33 demonstrats enhanced microsomal stability (T1/2=29 min). Antimalarial agent 33 has no significant cytotoxicity against primary hepatocytes .
    Antimalarial agent <em>33</em>
  • HY-151921

    p38 MAPK Inflammation/Immunology
    Anti-inflammatory agent 33 is a potent p38α inhibitor. Anti-inflammatory agent 33 inhibits NO production. Anti-inflammatory agent 33 inhibits LPS-induced iNOS, COX-2, p-p38α, p-MK2 protein expression. Anti-inflammatory agent 33 shows anti-inflammatory activity .
    Anti-inflammatory agent <em>33</em>
  • HY-142490

    Ras Cancer
    KRAS G12C inhibitor 33 is a KRAS G12C inhibitor extracted from patent WO2021244603A1, compound 1. KRAS G12C inhibitor 33 can be used for the research of cancer .
    KRAS G12C inhibitor <em>33</em>
  • HY-135732

    Androgen Receptor Cancer
    SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity .
    SK<em>33</em>
  • HY-141797

    Histone Methyltransferase PROTACs Cancer
    MS33 is a potent WDR5 degrader, with Kds of 870 nM and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia [3].
    MS<em>33</em>
  • HY-150700

    ERK Metabolic Disease
    RLX-33 is a potent, selective and blood-brain barrier (BBB) penetrant relaxin family peptide 3 (RXFP3) antagonist, also blocks relaxin-3-induced ERK1/2 phosphorylation, with IC50 values of 2.36 μM for RXFP3, 7.82 and 13.86 μM for ERK1 and ERK2 phosphorylation, respectively. RLX-33 can block the stimulation of food intake induced by the RXFP3-selective agonist R3/I5 in rats. RLX-33 can be used for the research of metabolic syndrome .
    RLX-<em>33</em>
  • HY-100455
    RK-33
    1 Publications Verification

    RK-33 is an RNA helicase inhibitor against DDX3, and inhibits its helicase activity.
    RK-<em>33</em>
  • HY-156717

    Others Inflammation/Immunology
    RE-33 is an analgesic compound. RE-33 has blood brain barrier penetration ability .
    RE-<em>33</em>
  • HY-W717329

    Aminopeptidase Cardiovascular Disease
    EC33 is a selective aminopeptidase A (APA) inhibitor. EC33 blocks the pressor response of exogenous Ang II. EC33 does not cross the blood-brain barrier. EC33 has the potential for salt-dependent model of hypertension research .
    EC<em>33</em>
  • HY-157802

    Sodium Channel Neurological Disease
    LTGO-33 is a potent and selective voltage-gated sodium channel NaV1.8 inhibitor. LTGO-33 inhibits NaV1.8 in the nM potency range and exhibits over 600-fold selectivity against human NaV1.1-NaV1.7 and NaV1.9. LTGO-33 exhibits state-independent inhibition with similar potencies on channels in the closed and inactivated conformations. LTGO-33 inhibits native TTX-R NaV1.8 currents in non-human primate and human DRG neurons, where it reduces action potential firing. LTGO-33 can be used for pain disorders research .
    LTGO-<em>33</em>
  • HY-B1260S1

    CTAB-d33; Cetyltrimethylammonium-d33 bromide; Hexadecyltrimethylammonium-d33 bromide

    Isotope-Labeled Compounds Others
    Cetrimonium-d33 (bromide) is the deuterium labeled Cetrimonium bromide[1]. Cetrimonium bromide (CTAB) is an amine based cationic quaternary surfactant, is one of the components of the topical antiseptic Cetrimide.
    Cetrimonium-d<em>33</em> bromide
  • HY-W284558S

    Sodium hexadecyl sulphate-d33

    Isotope-Labeled Compounds Others
    Sodium hexadecyl sulfate-d33 is the deuterium labeled Sodium hexadecyl sulfate[1].
    Sodium hexadecyl sulfate-d<em>33</em>
  • HY-124775

    Phosphodiesterase (PDE) Neurological Disease
    (S)-C33 is a potent and selective PDE9 (phosphodiesterase-9) inhibitor, with an IC50 of 11 nM. (S)-C33 can be used for central nervous system diseases and diabetes research .
    (S)-C<em>33</em>
  • HY-144106

    HCV Infection
    HCV-IN-33 (Compound (S)-3i) is an HCV entry inhibitor .
    HCV-IN-<em>33</em>
  • HY-P0323

    Arenavirus Infection
    GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus, and can upregulate H-2D b molecules at the RMA-S (Db Kb) cell surface with a SC50 of 344 nM .
    GP(<em>33</em>-41)
  • HY-123938

    CYH33

    PI3K Cancer
    Risovalisib (CYH33) is an orally active, highly selective PI3 inhibitor with IC50s of 5.9 nM/598 nM/78.7 nM/225 nM against α/β/δ/γ isoform, respectively. Risovalisib inhibits phosphorylation of Akt, ERK and induces significant G1 phase arrest in breast cancer cells and non-small cell lung cancer (NSCLC) cells. Risovalisib has potent activity against solid tumors [3].
    Risovalisib
  • HY-112612

    GPR88 Neurological Disease
    RTI-13951-33 is a potent, selective, and brain-penetrant GPR88 agonist, with an EC50 of 25 nM in GPR88 cAMP functional assay. RTI-13951-33 reduces alcohol reinforcement and intake behaviors in rats .
    RTI-13951-<em>33</em>
  • HY-112612A
    RTI-13951-33 hydrochloride
    1 Publications Verification

    GPR88 Neurological Disease
    RTI-13951-33 hydrochloride is a potent, selective, and brain-penetrant GPR88 agonist, with an EC50 of 25 nM in GPR88 cAMP functional assay. RTI-13951-33 hydrochloride reduces alcohol reinforcement and intake behaviors in rats .
    RTI-13951-<em>33</em> hydrochloride
  • HY-120348

    Potassium Channel Cardiovascular Disease Neurological Disease
    ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) with EC50s of 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively .
    ML67-<em>33</em>
  • HY-129944

    Phospholipase Inflammation/Immunology
    MJ33-OH is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6 .
    MJ<em>33</em>-OH
  • HY-130838

    Bacterial Infection
    JH-LPH-33, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. JH-LPH-33 displays outstanding antibiotic activity with a MIC value of 0.66 μg/mL .
    JH-LPH-<em>33</em>

Inquiry Online

Submit your filled information, we will contact you soon.

Salutation: * Country or Region:
* Applicant Name: * Organization Name:
* Department:    
* Email Address: * Product Name:
Cat. No.: * Requested quantity:
* Phone Number:    
Remarks:

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

 

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

 

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: