42-(2-Tetrazolyl)rapamycin

Cat. No.: HY-12424A Purity: 98.65%: FAQs
Data Sheet SDS COA Handling Instructions

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42-(2-Tetrazolyl)rapamycin is a proagent compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1. Rapamycin is a specific mTOR inhibitor.

For research use only. We do not sell to patients.

42-(2-Tetrazolyl)rapamycin Chemical Structure

CAS No. : 221877-56-1

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 383	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 383	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 750	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Other Forms of 42-(2-Tetrazolyl)rapamycin:

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Purity & Documentation
References
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Description

42-(2-Tetrazolyl)rapamycin is a proagent compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1. Rapamycin is a specific mTOR inhibitor.

Molecular Weight

966.21

Formula

C₅₂H₇₉N₅O₁₂

CAS No.

221877-56-1

Appearance

Solid

Color

White to off-white

SMILES

[H][C@]1(C(O[C@@]([C@@H](C[C@H]2C[C@@H](OC)[C@@H](N3N=CN=N3)CC2)C)([H])CC([C@@H](/C=C([C@@H](O)[C@H]4OC)\C)C)=O)=O)N(C(C([C@@]5(O)[C@H](C)CC[C@](C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C4=O)OC)([H])O5)=O)=O)CCCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 130 mg/mL (134.55 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0350 mL	5.1749 mL	10.3497 mL
5 mM	0.2070 mL	1.0350 mL	2.0699 mL
10 mM	0.1035 mL	0.5175 mL	1.0350 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.65%

Select Batch:

Data Sheet (280 KB) SDS (251 KB)

COA (261 KB) HNMR (555 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Karl W. Mollison, et al. Compounds and methods for treatment and prevention of diseases. US 20080171763 A1.

[2]. Ballou LM, et al. Rapamycin and mTOR kinase inhibitors. J Chem Biol. 2008 Nov;1(1-4):27-36. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0350 mL	5.1749 mL	10.3497 mL	25.8743 mL
	5 mM	0.2070 mL	1.0350 mL	2.0699 mL	5.1749 mL
	10 mM	0.1035 mL	0.5175 mL	1.0350 mL	2.5874 mL
	15 mM	0.0690 mL	0.3450 mL	0.6900 mL	1.7250 mL
	20 mM	0.0517 mL	0.2587 mL	0.5175 mL	1.2937 mL
	25 mM	0.0414 mL	0.2070 mL	0.4140 mL	1.0350 mL
	30 mM	0.0345 mL	0.1725 mL	0.3450 mL	0.8625 mL
	40 mM	0.0259 mL	0.1294 mL	0.2587 mL	0.6469 mL
	50 mM	0.0207 mL	0.1035 mL	0.2070 mL	0.5175 mL
	60 mM	0.0172 mL	0.0862 mL	0.1725 mL	0.4312 mL
	80 mM	0.0129 mL	0.0647 mL	0.1294 mL	0.3234 mL
	100 mM	0.0103 mL	0.0517 mL	0.1035 mL	0.2587 mL