1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP

AZ6102 (Synonyms: AZ 6102; AZ-6102)

Cat. No.: HY-12975
Handling Instructions

AZ6102 is a potent TNKS1/2 inhibitor (IC50=3/1 nM) that has 100-fold selectivity against other PARP family enzymes (IC50: 0.5-3 μM) and shows 5 nM Wnt pathway inhibition in DLD-1 cells.

For research use only. We do not sell to patients.
AZ6102 Chemical Structure

AZ6102 Chemical Structure

CAS No. : 1645286-75-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO $132 In-stock
5 mg $120 In-stock
10 mg $200 In-stock
25 mg $390 In-stock
50 mg $600 In-stock
100 mg $900 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

AZ6102 is a potent TNKS1/2 inhibitor (IC50=3/1 nM) that has 100-fold selectivity against other PARP family enzymes (IC50: 0.5-3 μM) and shows 5 nM Wnt pathway inhibition in DLD-1 cells. IC50 value: 3 nM (TNKS1), 1 nM (TNKS2) [1] Target: TNKS1 in vitro: AZ6102 is profiled against a panel of PARP family enzymes and shows excellent potency as a dual TNKS1 and TNKS2 inhibitor with good selectivity against PARPs 1, 2, and 6 (IC50=3 nM, 1 nM, 2μM, 0.5μM, and >3μM for TNKS1, TNKS2, PARP1, PARP2, and PARP6, respectively)[1]. in vivo: Dosed at 25 mg/kg IV to nude mice, AZ6102 has a clearance (CL) of 24 mL/min·kg and a half-life of 4 h. The bioavailability of AZ6102 in mouse and rat is only moderate at 12% and 18%, respectively[1].

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.3336 mL 11.6678 mL 23.3356 mL
5 mM 0.4667 mL 2.3336 mL 4.6671 mL
10 mM 0.2334 mL 1.1668 mL 2.3336 mL
References
M.Wt

428.53

Formula

C₂₅H₂₈N₆O

CAS No.

1645286-75-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
AZ6102
Cat. No.:
HY-12975
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