2. GPCR/G Protein
  3. GnRH Receptor
  4. Abarelix

Abarelix  (Synonyms: R3827; PPI 149)

Cat. No.: HY-13534 Purity: 99.90%
COA Handling Instructions

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Abarelix (R3827; PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer treatment.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Abarelix Chemical Structure

Abarelix Chemical Structure

CAS No. : 183552-38-7

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5 mg USD 70 In-stock
10 mg USD 110 In-stock
25 mg USD 230 In-stock
50 mg USD 370 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Abarelix:

Abarelix Related Antibodies

Top Publications Citing Use of Products
WB

    Abarelix purchased from MedChemExpress. Usage Cited in: Am J Physiol Endocrinol Metab. 2020 Jul 1;319(1):E81-E90.  [Abstract]

    EPHA7, ERα, and ERβ protein expression in the hypothalamus of abarelix-treated rats injected with EPHA7-Fc.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Abarelix (R3827; PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer treatment.

    In Vitro

    Abarelix (30 and 300 µg/mL) causes significantly increased histamine release[1]. Abarelix is the first GnRH antagonist to be developed, and can produce rapid and sustained decreases in testosterone to castrate levels without the need for co-administration of an antiandrogen, and with a very low complication rate in the short term[2]. Abarelix demonstrates to promptly and substantially reduce follicle-stimulating hormone levels to lower than LHRH agonist. Abarelix does not cause a surge in serum testosterone that can precipitate a flare phenomenon or worsening of disease, particularly dangerous for patients with metastatic, symptomatic disease, and produces medical castration more quickly[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Abarelix Related Antibodies
    Clinical Trial
    Molecular Weight

    1416.06

    Formula

    C72H95ClN14O14
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence Shortening

    Ac-{d-2-Nal}-{d-4-Cpa}-{d-3-Pal}-S-{NMyr}-{d-Asp}-L-K(ipr)-P-{d-Ala}-NH2
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 14.2 mg/mL (10.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.7062 mL 3.5309 mL 7.0618 mL
    5 mM 0.1412 mL 0.7062 mL 1.4124 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.90%

    COA (251 KB) LCMS (267 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 0.7062 mL 3.5309 mL 7.0618 mL 17.6546 mL
    5 mM 0.1412 mL 0.7062 mL 1.4124 mL 3.5309 mL
    10 mM 0.0706 mL 0.3531 mL 0.7062 mL 1.7655 mL
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    Abarelix Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Abarelix183552-38-7R3827 PPI 149R 3827R-3827PPI149PPI 149PPI-149GnRH ReceptorGonadotropin releasing hormone receptorGNRHRInhibitorinhibitorinhibit

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