Anitrazafen (Synonyms: LY 122512)

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Anitrazafen is a topically effective antiinflammatory agent.

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Anitrazafen Chemical Structure

CAS No. : 63119-27-7

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Description	Anitrazafen is a topically effective antiinflammatory agent.
In Vivo	Anitrazafen is a topically effective antiinflammatory agent. The disposition of ¹⁴C in normal and in bile-duct cannulated rats after oral administration of a single dose of 25 mg/kg of [3-¹⁴C]Anitrazafen shows the drug to be well absorbed from the gastro-intestinal tract and biliary excretion to be the major route of elimination of drug and/or metabolites. Plasma concentrations of total ¹⁴C after subcutaneous administration of [3-¹⁴C]Anitrazafen in corn oil solution are about one half those found after oral administration^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	307.35
Formula	C₁₈H₁₇N₃O₂
CAS No.	63119-27-7
SMILES	CC1=NC(C2=CC=C(OC)C=C2)=C(C3=CC=C(OC)C=C3)N=N1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (275 KB) Handling Instructions (2659 KB)
References	[1]. Sullivan HR, et al. Absorption and metabolism of anitrazafen, a topically effective anti-inflammatory agent, in the rat. Xenobiotica. 1981 Jan;11(1):9-22. [Content Brief]

Animal Administration
^[1]

Male albino rats (200 to 250 g) are fasted for 24 h before experiment. [3-¹⁴C]Anitrazafen (25 mg/kg) is administered orally to twelve rats. At specific times after dosing, three animals are killed by decapitation and samples of blood and appropriate tissues are removed. Duplicate weighed samples of blood and each tissue are removed for ¹⁴C assay^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Sullivan HR, et al. Absorption and metabolism of anitrazafen, a topically effective anti-inflammatory agent, in the rat. Xenobiotica. 1981 Jan;11(1):9-22. [Content Brief]

Anitrazafen Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anitrazafen63119-27-7LY 122512LY122512LY-122512OthersInhibitorinhibitorinhibit

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Anitrazafen (Synonyms: LY 122512)

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