2. Anti-infection
  3. Parasite
  4. Artemether

Artemether  (Synonyms: Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224)

Cat. No.: HY-N0402 Purity: 98.42%
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Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria.

For research use only. We do not sell to patients.

Artemether Chemical Structure

Artemether Chemical Structure

CAS No. : 71963-77-4

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of Artemether:

Artemether Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria[1].

IC50 & Target

Plasmodium

 

In Vitro

Artemether (0-200 μg/mL, 24-72 h) inhibits rat C6 glioma cell growth in a dose- and time-dependent manner[2].
Artemether (0-10 μM, 72 h) inhibits RANKL-induced osteoclast (osteoclast precursor cells (BMMs)) formation and related gene expression (TRAP, NFATc1, V-ATPase-d2, CTSK, DC-STAMP, MMP-9)[2].
Artemether (48 or 96 h) inhibits ConA- or alloantigen-induced BALB/c splenocyte proliferation (IC50: 6.3 and 3.5 μM)[4].
Artemether (0-50 μM, 16-36 h) inhibits production of the IL-2 and IFN-γ in BALB/c splenocyte[4].
Artemether (0-50 μM, 72 h) inhibits ConA-induced splenocyte, CD4+T- and CD8+ T-cell divisions, and inhibits cell cycle progression through G1/S transition[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Artemether Related Antibodies

Western Blot Analysis[3]

Cell Line: RAW264.7 cells (treated with 100 ng/mL RANKL)
Concentration: 10 μM
Incubation Time: 6 h
Result: Inhibited the activation of MAPK subfamilies, including ERK, JNK, and p38.

Cell Cycle Analysis[4]

Cell Line: ConA-stimulated T lymphocytes
Concentration: 1, 10 and 50 μM
Incubation Time: 72 h
Result: Arrested 47, 56 and 91% (at 1, 10 and 50 μM) of the cells at G0/G1 phases, respectively.
In Vivo

Artemether (0-66 mg/kg, p.o.) inhibits tumor growth and angiogenesis in SD rats bearing C6 glioma cells[2].
Artemether (10 mg/kg, i.p., 8 days) protects mice against LPS-induced osteolytic bone loss[3].
Artemether (50 and 100 mg/kg, p.o.) inhibits T-cell-mediated immune responses (ear swelling) in DNFB-induced DTH model in BALB/c mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS (5 mg/kg) treated mice[3]
Dosage: 10 mg/kg
Administration: i.p., 8 days
Result: Prevented LPS induced osteolytic bone loss and the reduction in bone volume.
Increased bone volume/total volume (BV/TV), decreased osteoclast surface/bone surface (Oc.S/BS) and number of TRAP-positive cells.
Clinical Trial
Molecular Weight

298.37

Formula

C16H26O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H]1[C@@H](OC)O[C@@]2([H])[C@]34[C@@]([C@H](C)CC[C@]41[H])([H])CC[C@@](O2)(C)OO3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (335.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3515 mL 16.7577 mL 33.5154 mL
5 mM 0.6703 mL 3.3515 mL 6.7031 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3515 mL 16.7577 mL 33.5154 mL 83.7886 mL
5 mM 0.6703 mL 3.3515 mL 6.7031 mL 16.7577 mL
10 mM 0.3352 mL 1.6758 mL 3.3515 mL 8.3789 mL
15 mM 0.2234 mL 1.1172 mL 2.2344 mL 5.5859 mL
20 mM 0.1676 mL 0.8379 mL 1.6758 mL 4.1894 mL
25 mM 0.1341 mL 0.6703 mL 1.3406 mL 3.3515 mL
30 mM 0.1117 mL 0.5586 mL 1.1172 mL 2.7930 mL
40 mM 0.0838 mL 0.4189 mL 0.8379 mL 2.0947 mL
50 mM 0.0670 mL 0.3352 mL 0.6703 mL 1.6758 mL
60 mM 0.0559 mL 0.2793 mL 0.5586 mL 1.3965 mL
80 mM 0.0419 mL 0.2095 mL 0.4189 mL 1.0474 mL
100 mM 0.0335 mL 0.1676 mL 0.3352 mL 0.8379 mL
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Artemether Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Artemether71963-77-4Dihydroqinghaosu methyl ether Dihydroartemisinin methyl ether SM224SM224SM 224SM-224ParasiteInhibitorinhibitorinhibit

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