1. (4-Acetamidocyclohexyl) nitrate

(4-Acetamidocyclohexyl) nitrate  (Synonyms: BM121307)

Cat. No.: HY-100295
Handling Instructions

(4-Acetamidocyclohexyl) nitrate (BM121307) is a guanylate cyclase activator.

For research use only. We do not sell to patients.

(4-Acetamidocyclohexyl) nitrate Chemical Structure

(4-Acetamidocyclohexyl) nitrate Chemical Structure

CAS No. : 137213-91-3

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Description

(4-Acetamidocyclohexyl) nitrate (BM121307) is a guanylate cyclase activator.

In Vivo

The elimination of BM121307 and its metabolites via urine and feces amount to 76.5% after oral application, and to 80.7% of the applied dose after intravenous application. The major amount of radioactivity is eliminated via urine (69.4% and 73.6% of the dose, respectively), whereas the fecal elimination is found to be negligible. Investigations of the urinary samples show that the drug is metabolized to a high percentage trans-N-(4-Hydroxycyclohexyl) acetamide is the main metabolite; 73% of the radioactive compounds (after p.o.-administration and 69% after intravenous application could be identified as the alcohol of BM121307; the amounts of the drug totaled 9% and 13%, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

202.21

Formula

C8H14N2O4

CAS No.
SMILES

CC(N[C@@H]1CC[C@@H](O[N+]([O-])=O)CC1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
Animal Administration
[1]

Dogs[1]

The biotransformation of BM121307 in the dog is examined after oral and intravenous administration. For that purpose, the organic nitrate is synthesized as radioactive [14C]- and as [13C]-labeled compounds. The defined isotopic mixture is administered to the dogs. Within the examined period of 168 h, the elimination of BM121307 is measured[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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(4-Acetamidocyclohexyl) nitrate
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HY-100295
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