Bometolol Hydrochloride

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Bometolol Hydrochloride is a beta-adrenergic blocking agent, used for the research of cardiovascular disease.

For research use only. We do not sell to patients.

Bometolol Hydrochloride Chemical Structure

CAS No. : 65023-16-7

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α adrenergic receptor β adrenergic receptor

Biological Activity
Protocol
Purity & Documentation
References
Customer Review

Description	Bometolol Hydrochloride is a beta-adrenergic blocking agent, used for the research of cardiovascular disease.
IC₅₀ & Target	Beta-adrenergic receptor^[1]
In Vivo	Bometolol (10-30 mg/kg, p.o.) lowers the blood pressure dose-dependently in spontaneously hypertensive rats, deoxycorticosterone and salt hypertensive rats and two kindey, one clip hypertensive rats. In subchronic study, Bometolol (10-30 mg/kg, or 100-300 mg/kg, p.o.) dose-dependently decreases heart rate, plasma renin activity, heart and kindey weitht and incidence of vascular lesion, but shows no antihypertensive effects in all the hypertensive rats^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	508.99
Formula	C₂₅H₃₃ClN₂O₇
CAS No.	65023-16-7
SMILES	O=C1NC2=C(C(OCC(O)CNCCC3=CC=C(OC)C(OC)=C3)=CC=C2OCC(C)=O)CC1.[H]Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. Watanabe TX, et al. Acute and subchronic effects of bometolol on blood pressure in hypertensive rats. J Pharmacobiodyn. 1981 Jul;4(7):505-12. [Content Brief]

Animal Administration
^[1]

Rats^[1]
In the acute experments, normal female Donryu strain (DON, 14-15 weeks, 250-270 g), and SHR (17-18 weeks, 180-200 g), DOC (7-9 weeks, 180-210 g), and CLIP (7-9 weeks, 180-210 g) hypertensive rats are used. Bometolol hydrochloride is dissolved in H₂O and 0.01% Tween 80 solution at a volume of 5 mL/kg body weight for the acute and subchronic studies, respectively. The doses are in terms of the free base. The solution is administratered orally by a gastric tube. In the acute experiment, H₂O (5 mL/kg) is giver to the control groups. In the subchronic experment, the drug is administered once a day for 5 weeks, 5 days per week, and Tween 80 solution (5 mL/kg) is given to the control groups^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Watanabe TX, et al. Acute and subchronic effects of bometolol on blood pressure in hypertensive rats. J Pharmacobiodyn. 1981 Jul;4(7):505-12. [Content Brief]