1. Cell Cycle/DNA Damage
  2. Eukaryotic Initiation Factor (eIF)

Briciclib (Synonyms: ON 014185)

Cat. No.: HY-16366 Purity: 99.15%
Data Sheet SDS Handling Instructions

Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells.

For research use only. We do not sell to patients.
Briciclib Chemical Structure

Briciclib Chemical Structure

CAS No. : 865783-99-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 438 In-stock
1 mg USD 180 In-stock
5 mg USD 420 In-stock
10 mg USD 600 In-stock
50 mg USD 1800 In-stock
100 mg USD 2520 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

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Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells. Target: Cyclin D1 in vitro: Briciclib inhibits the proliferation of MCL (JEKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines at nanomolar concentrations (GI50 = 9.8 - 12.2 nM). [1] Cyclin D1 is a protein required for normal progression through the cell cycle and is overexpressed in many tumors. Cyclin D1 expression is regulated through a process termed cap-dependent translation, which requires the function of eukaryotic initiation factor 4E (eIF4E) protein. In vitro evidence indicates that briciclib binds to eIF4E, blocking cap-dependent translation of cyclin D1 and other cancer proteins (c-MYC, VEGF), leading to tumor cell death. Briciclib is potent and shown to be active in nonclinical tumor models when combined with several chemotherapeutics.

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Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.1078 mL 10.5392 mL 21.0784 mL
5 mM 0.4216 mL 2.1078 mL 4.2157 mL
10 mM 0.2108 mL 1.0539 mL 2.1078 mL
Please refer to the solubility information to select the appropriate solvent.
Molecular Weight






Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 31 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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