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Bunaftide  (Synonyms: Bunaftine; Bunaphtide; Meregon)

Cat. No.: HY-U00113
Handling Instructions

Bunaftide (Bunaftine; Bunaphtide; Meregon) is an antiarrhythmic agent.

For research use only. We do not sell to patients.

Bunaftide Chemical Structure

Bunaftide Chemical Structure

CAS No. : 32421-46-8

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Description

Bunaftide (Bunaftine; Bunaphtide; Meregon) is an antiarrhythmic agent.

In Vitro

At concentrations of 0.5-2.0 mM, Bunaftide causes contraction and rounding of the cells with loss of microvilli-like processes. Aggregates of dense, partly granular, partly fibrillar material form in the cytoplasm and the rough endoplasmic reticulum became vesiculated. Bundles of actin filaments are disrupted, forming rings, coils, and granules. 0.4 mM Bunaftide increases and 0.8-1.0 mM markedly decreases the percentage of mitotic cells, without accumulation of cells in any particular stage of mitosis. The drug may arrest the cell cycle at some point before mitosis; it may have a critical concentration above which the arrest becomes permanent[1]. Bunaftide at 1, 5 and 10 mg/L produces a concentration-dependent depression of the maximum rate of rise of the action potential in guinea pig papillary muscle preparations without affecting the resting membrane potential and the action potential amplitude. The action potential duration (APD50, APD90) is significantly prolonged by the treatment with 1 and 5 mg/L Bunaftide, while it is not changed by the treatment with 10 mg/L[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

326.48

Formula

C21H30N2O

CAS No.
SMILES

O=C(C1=C2C=CC=CC2=CC=C1)N(CCCC)CCN(CC)CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
Cell Assay
[1]

Human embryonic fibroblasts and HeLa cells are seeded into 35-mm plastic Petri dishes at a density of 1x105 cells/cm2. Bunaftide is used in final concentrations of 0.1-2.0 mM. The cells are exposed to the drug for periods ranging from 15 min to 24 h. To allow the cells to recover, the Bunaftide medium is removed and the cultures are left in standard medium for 4-24 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Bunaftide Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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