1. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  2. Nucleoside Antimetabolite/Analog Drug Metabolite Apoptosis DNA/RNA Synthesis
  3. CNDAC

CNDAC is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC induces DNA damage and apoptosis.

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CNDAC Chemical Structure

CNDAC Chemical Structure

CAS No. : 135598-68-4

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Description

CNDAC is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC induces DNA damage and apoptosis[1][2].

In Vitro

CNDAC has a unique mechanism of action: after incorporation into DNA, it induces single-strand breaks (SSBs) that are converted into double-strand breaks (DSBs) when cells go through a second S phase[1].
Lack of Rad51D and XRCC3 sensitizes cells to CNDAC (0-1 μM; 24 h)[1].
CNDAC (0-100 μM; 3 days) inhibits proliferation of HL-60 and THP-1 cells[2].
CNDAC (0-10 μM; 3-6 days) induces apoptosis in HL-60 and THP-1 cells[2].
CNDAC (6 μM; 48 h) induces cell cycle arrest in the G2 phase following a delayed S phase in HCT116 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF CHO cells
Concentration: 0-1 μM
Incubation Time: 24 h
Result: Inhibited cell survival with IC50s of 0.006, 0.32, 0.48 and 0.0053 μM against Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF cell lines, respectively.

Cell Proliferation Assay[2]

Cell Line: HL-60 and THP-1 cells
Concentration: 0-100 μM
Incubation Time: 3 days
Result: Inhibited proliferation with IC50s of 1.5832 μM and 0.84 μM against HL-60 and THP-1 cells, respectively.

Apoptosis Analysis[2]

Cell Line: HL-60 and THP-1 cells
Concentration: 0, 0.5, 1, 2, 3, 4, 5 and 10 μM
Incubation Time: 3, 4, 5, and 6 days
Result: Induced apoptosis in both cells.

Cell Cycle Analysis[3]

Cell Line: HCT116
Concentration: 6 μM
Incubation Time: 48 h
Result: 36 and 36% of cells were arrested in late-S and G2/M phases, respectively.
In Vivo

CNDAC (20mg/kg; i.p.; daily for 10 days) shows antitumor activity in mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CDF1 mice, P388 tumor model[4]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection, daily for 10 days
Result: Greatly increased the survival time and survival rate.
Molecular Weight

252.23

Formula

C10H12N4O4

CAS No.
SMILES

O=C(N=C(N)C=C1)N1[C@H]2[C@@H](C#N)[C@H](O)[C@@H](CO)O2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CNDAC
Cat. No.:
HY-16445A
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