2. Anti-infection
  3. Beta-lactamase Bacterial Antibiotic
  4. Cefditoren (Pivoxil)

Cefditoren (Pivoxil)  (Synonyms: Cefditoren pivoxyl; Cefditoren pivaloyloxymethyl ester; ME 1207)

Cat. No.: HY-17452A Purity: 99.31%
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Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.

For research use only. We do not sell to patients.

Cefditoren (Pivoxil) Chemical Structure

Cefditoren (Pivoxil) Chemical Structure

CAS No. : 117467-28-4

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 73 In-stock
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5 mg USD 42 In-stock
10 mg USD 66 In-stock
50 mg USD 185 In-stock
100 mg USD 251 In-stock
200 mg USD 304 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Cefditoren (Pivoxil):

Cefditoren (Pivoxil) Related Antibodies

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Description

Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections[1][2].

IC50 & Target

β-lactam

 

In Vitro

Cefditoren (Pivoxil) shows good activity against pneumoniae, S. pyogenes, Staphylococcus aureus, H. influenzae and H. parainfluenzae, M. catarrhalis[1].

Organism MIC50 (mg/L) MIC90 (mg/L) susceptible (%)
Gram-positive organisms
Streptococcus pneumoniae
(untyped)a		 0.015-0.25 0.12-1
PS ≤0.008-0.03 0.015-0.25 99-100
PI 0.06-0.5 0.25-0.5 94-100
PR 0.25-1 0.5-2 7-100
S. pyogenes ≤0.008-0.03 0.015-0.03 100
Staphylococcus aureus (MS) 0.12-0.5 0.5-1 50-100
Gram-negative organisms
Haemophilus ≤0.008-≤0.03 0.015-0.13
influenzae (untyped)b
β-Lactamase + ≤0.008-0.03 0.015-0.06 100
β-Lactamase - ≤0.008-0.03 0.015-0.06 100
H. parainfluenzaeb ≤0.03 0.06
Moraxella 0.03-0.5 0.25-1 96
catarrhalis (untyped)b
β-Lactamase + ≤0.03-0.25 0.12-0.5 100
β-Lactamase - ≤0.008-0.03 0.015-0.06 100
a Including PS, PI and PR strains.
b Including both β-lactamase-positive and -negative strains.
MIC50/90=mean minimum inhibitory concentrations required to inhibit the growth of 50% or 90% of bacterial strains; MS=susceptible to meticillin; PI=intermediate susceptibility to penicillin; PR=resistant to penicillin; PS=susceptible to penicillin.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefditoren (Pivoxil) Related Antibodies
In Vivo

Pharmacokinetics in mice[1]：

Cefditoren (mg/kg) C0 (µg/ml) t1/2 (h) AUClast (µg× h/ml) Tlast (h)
6.25 53.0 0.9 30.4 6
12.5 168.4 1.1 64.1 8
25 232.5 0.9 101.3 8
50 290.6 1.1 124.4 8

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

620.72

Formula

C25H28N6O7S3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(N12)=C(/C=C\C3=C(C)N=CS3)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)OCOC(C(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (161.10 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6110 mL 8.0552 mL 16.1103 mL
5 mM 0.3222 mL 1.6110 mL 3.2221 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.03 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (4.03 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6110 mL 8.0552 mL 16.1103 mL 40.2758 mL
5 mM 0.3222 mL 1.6110 mL 3.2221 mL 8.0552 mL
10 mM 0.1611 mL 0.8055 mL 1.6110 mL 4.0276 mL
15 mM 0.1074 mL 0.5370 mL 1.0740 mL 2.6851 mL
20 mM 0.0806 mL 0.4028 mL 0.8055 mL 2.0138 mL
25 mM 0.0644 mL 0.3222 mL 0.6444 mL 1.6110 mL
30 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3425 mL
40 mM 0.0403 mL 0.2014 mL 0.4028 mL 1.0069 mL
50 mM 0.0322 mL 0.1611 mL 0.3222 mL 0.8055 mL
60 mM 0.0269 mL 0.1343 mL 0.2685 mL 0.6713 mL
80 mM 0.0201 mL 0.1007 mL 0.2014 mL 0.5034 mL
100 mM 0.0161 mL 0.0806 mL 0.1611 mL 0.4028 mL
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Cefditoren (Pivoxil) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cefditoren (Pivoxil)117467-28-4Cefditoren pivoxyl Cefditoren pivaloyloxymethyl ester ME 1207ME1207ME 1207ME-1207Beta-lactamaseBacterialAntibioticβ-lactamasebroad-spectrum antibioticthird-generationoral cephalosporinβ lactamasesinfection diseasesInhibitorinhibitorinhibit

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