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Cetilistat  (Synonyms: ATL-962)

Cat. No.: HY-14471 Purity: ≥98.0%
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Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively.

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Cetilistat Chemical Structure

Cetilistat Chemical Structure

CAS No. : 282526-98-1

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Based on 1 publication(s) in Google Scholar

Cetilistat Related Antibodies

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Description

Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively[1].

IC50 & Target

IC50: 54.8 nM (rat pancreatic lipase), 5.95 nM (human pancreatic lipase)[1]
In Vitro

Cetilistat inhibits rat pancreatic lipase activity with an IC50 of 54.8 nM. Also, Cetilistat inhibits human pancreatic lipase activity with an IC50 of 5.95 nM, which is 9.2 times more potent than for rat pancreatic lipase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cetilistat Related Antibodies
In Vivo

Cetilistat (3, 10, 30, or 100 mg/kg) reduces intestinal fat absorption by inhibiting pancreatic lipase activity in male SD rats[1].
Cetilistat (4.9, 14.9, or 50.7 mg/kg; mixed into powdered high-fat diet; once a day; for three weeks) shows anti-obesity and antihyperlipidemic effects on DIO F344 rats by reducing intestinal fat absorption[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fifty male SD rats (eight weeks of age)[1]
Dosage: 3, 10, 30, or 100 mg/kg
Administration: Orally administered; prepared in 0.5 % methylcellulose (MC) suspension
Result: Dose-dependently reduced AUC 0-6 h of plasma triglyceride induced by oral loading of Intrafat 20%. The effect was statistically significant at 3 mg/kg, reaching 45% reduction, while an almost 90 % reduction was achieved at 100 mg/kg.
Animal Model: Male diet-induced obesity (DIO) F344 rats (five weeks of age)[1]
Dosage: 4.9, 14.9, or 50.7 mg/kg
Administration: Administered as food admixture in a high-fat diet; once a day; for three weeks
Result: Significantly and dose-dependently reduced body weight gain compared with control.
Clinical Trial
Molecular Weight

401.58

Formula

C25H39NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=C(N=C(OCCCCCCCCCCCCCCCC)OC2=O)C2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

H2O : < 0.1 mg/mL (insoluble)

*Cetilistat is usually formulated as a suspension.

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Purity & Documentation
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Cetilistat Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cetilistat282526-98-1ATL-962ATL962ATL 962Othershigh-fat dietcholesterolpancreaticlipaseanti-obesityInhibitorinhibitorinhibit

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