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  2. Disease Research Fields Plants Flavonoids Phenols
  3. Papilionaceae Cancer Flavonols Polyphenols
  4. Astragalus complanatus
  5. Complanatoside A

Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus, and currently it is used as a quality control index for A. complanatus in the 2010 edition of the Chinese Pharmacopoeia.

For research use only. We do not sell to patients.

Complanatoside A Chemical Structure

Complanatoside A Chemical Structure

CAS No. : 146501-37-3

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Based on 1 publication(s) in Google Scholar

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Description

Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus, and currently it is used as a quality control index for A. complanatus in the 2010 edition of the Chinese Pharmacopoeia.

In Vitro

A simple and sensitive LC-MS/MS method is developed for the determination of complanatoside A in rat plasma over the range of 2.3–575 ng/mL. Complanatoside A is extracted from plasma by a protein precipitation procedure, separated by LC and detected by MS/MS in positive electrospray ionization mode. The lower limit of quantification is established at 2.3 ng/mL. Intra- and inter-day precisions (LLOQ, low-QC, med-QC and high-QC) are less than 7.9%, and accuracies are between 94.0 and 105.1%. Matrix effect is acceptable (97.9–103.0%) and extraction recovery is reproducible (88.5–94.4%). Complanatoside A is stable in the investigated conditions. The method is applied to the pharmacokinetics of complanatoside A in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

642.52

Formula

C27H30O18

CAS No.
SMILES

O=C1C(O[C@@H]([C@@H]([C@@H](O)[C@@H]2O)O)O[C@@H]2CO)=C(C3=CC(O)=C(O[C@@H]([C@@H]([C@@H](O)[C@@H]4O)O)O[C@@H]4CO)C(O)=C3)OC5=CC(O)=CC(O)=C15

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 35.7 mg/mL (55.56 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5564 mL 7.7819 mL 15.5637 mL
5 mM 0.3113 mL 1.5564 mL 3.1127 mL
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Purity & Documentation
References
Animal Administration
[1]

Rats: The rats are fasted for 12 h before the experiment. Complanatoside A is formulated in water and a single dose of 30 mg/kg is administered by oral gavage. Blood samples are obtained from the vena orbitalis just prior to dose and at 0.083, 0.167, 0.25, 0.5, 0.75, 1, 2, 3, 5, 7, 10 and 14 h after administration. After centrifugation at 6000g for 10 min, the upper plasma is collected and stored at–20°C before analysis. The data are calculated by Drug&Statistics software[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5564 mL 7.7819 mL 15.5637 mL 38.9093 mL
5 mM 0.3113 mL 1.5564 mL 3.1127 mL 7.7819 mL
10 mM 0.1556 mL 0.7782 mL 1.5564 mL 3.8909 mL
15 mM 0.1038 mL 0.5188 mL 1.0376 mL 2.5940 mL
20 mM 0.0778 mL 0.3891 mL 0.7782 mL 1.9455 mL
25 mM 0.0623 mL 0.3113 mL 0.6225 mL 1.5564 mL
30 mM 0.0519 mL 0.2594 mL 0.5188 mL 1.2970 mL
40 mM 0.0389 mL 0.1945 mL 0.3891 mL 0.9727 mL
50 mM 0.0311 mL 0.1556 mL 0.3113 mL 0.7782 mL
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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