2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. D-Panthenol

D-Panthenol  (Synonyms: Dexpanthenol)

Cat. No.: HY-B1391 Purity: ≥98.0%
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D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell. D-panthenol exhibits nephroprotective effect in AKI, promotes tissue repair and regeneration.

For research use only. We do not sell to patients.

D-Panthenol Chemical Structure

D-Panthenol Chemical Structure

CAS No. : 81-13-0

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Oil + Solvent
10 mM * 1 mL in DMSO
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 USD 61 In-stock
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Oil
500 mg USD 55 In-stock
1 g USD 66 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of D-Panthenol:

D-Panthenol Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell. D-panthenol exhibits nephroprotective effect in AKI, promotes tissue repair and regeneration.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

D-panthenol exhibits neuroprotective activity against tBHP (0-100 μM) and FESO4 (0.5 mM) induced oxidation in mitochondria through inhibiting lipid peroxidation, thereby improves mitochondrial metabolism, reverses redox potential of the glutathione system and decreases the level of S-glutathionylated proteins[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-Panthenol Related Antibodies
In Vivo

D-panthenol (200 mg/kg, i.p. for 7 days) enhances tolerance of kidney tissues against oxidative damage through limited lipid peroxidation and SOD activity in Rhabdomyolysis-Induced AKI in Wistar mice[2].
D-panthenol (200 mg/kg, i.p. for 7 days) exhibits nephroprotective effect through inhibiting inflammatory processes with decreased MPO activity and leukocyte infiltration in Rhabdomyolysis-Induced AKI in Wistar mice [2].
D-panthenol (4 mg as a spray, twice a day for 14 days) promotes wound healing through retaining the environment moisture, promoting tissue repair and regeneration in streptozotocin-induced diabetes mellitus C57BL/6 mice and db/db mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rhabdomyolysis-Induced AKI in Wistar mice[2]
Dosage: 200 mg/kg
Administration: intraperitoneal injection, 7 days
Result: Reduced leukocyten infiltration and MPO activity in kidney.
Animal Model: streptozotocin-induced DM C57BL/6 mice and db/db (T2D) mice[3]
Dosage: 4 mg/kg
Administration: as a spray, twice a day for 14 days
Result: Induced leukocyte prevalence, promoted clearance of necrotic debris from the wound. Induced collagen production from day 10.
Clinical Trial
Molecular Weight

205.25

Formula

C9H19NO4
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C([C@@H](C(C)(CO)C)O)NCCCO
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 110 mg/mL (535.93 mM; Need ultrasonic)

DMSO : 33 mg/mL (160.78 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8721 mL 24.3605 mL 48.7211 mL
5 mM 0.9744 mL 4.8721 mL 9.7442 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (10.13 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (10.13 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 4.8721 mL 24.3605 mL 48.7211 mL 121.8027 mL
5 mM 0.9744 mL 4.8721 mL 9.7442 mL 24.3605 mL
10 mM 0.4872 mL 2.4361 mL 4.8721 mL 12.1803 mL
15 mM 0.3248 mL 1.6240 mL 3.2481 mL 8.1202 mL
20 mM 0.2436 mL 1.2180 mL 2.4361 mL 6.0901 mL
25 mM 0.1949 mL 0.9744 mL 1.9488 mL 4.8721 mL
30 mM 0.1624 mL 0.8120 mL 1.6240 mL 4.0601 mL
40 mM 0.1218 mL 0.6090 mL 1.2180 mL 3.0451 mL
50 mM 0.0974 mL 0.4872 mL 0.9744 mL 2.4361 mL
60 mM 0.0812 mL 0.4060 mL 0.8120 mL 2.0300 mL
80 mM 0.0609 mL 0.3045 mL 0.6090 mL 1.5225 mL
100 mM 0.0487 mL 0.2436 mL 0.4872 mL 1.2180 mL
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D-Panthenol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Panthenol81-13-0DexpanthenolEndogenous MetaboliteneuroprotectiveAKIC57BL/6 micedb/db (T2D) miceWistar miceInhibitorinhibitorinhibit

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