1. Cell Cycle/DNA Damage
    NF-κB
  2. PPAR

DG172 dihydrochloride (Synonyms: DG 172 dihydrochloride; DG-172 dihydrochloride)

Cat. No.: HY-19737A Purity: 99.91%
Data Sheet SDS Handling Instructions

DG172 dihydrochloride is a novel PPARβ/δ-selective ligand showing high binding affinity (IC50 = 27 nM) and potent inverse agonistic properties.

For research use only. We do not sell to patients.
DG172 dihydrochloride Chemical Structure

DG172 dihydrochloride Chemical Structure

CAS No. : 1361504-77-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $66 In-stock
5 mg $60 In-stock
10 mg $100 In-stock
50 mg $390 In-stock
100 mg $670 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

DG172 dihydrochloride is a novel PPARβ/δ-selective ligand showing high binding affinity (IC50 = 27 nM) and potent inverse agonistic properties. IC50 value: 27 nM [1] Target: PPARβ/δ in vitro: DG172 is a PPARβ/δ-selective compound characterized by high affinity and potent repressive effects on PPARβ/δ target genes. DG172 also inhibits the expression of transcription factors driving granulocytic differentiation (Cebpe, Gfi1, and Klf5), and increases the levels of transcription factors promoting macrophage/DC differentiation (Irf4, Irf8, Spib, and Spic). [2] DG172 enhances TM4 cell proliferation. [3]

References
M.Wt

455.22

Formula

C₂₀H₂₂BrCl₂N₃

CAS No.

1361504-77-9

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
DG172 dihydrochloride
Cat. No.:
HY-19737A
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