1. DG172 dihydrochloride

DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC50 of 27 nM.

For research use only. We do not sell to patients.

DG172 dihydrochloride Chemical Structure

DG172 dihydrochloride Chemical Structure

CAS No. : 1361504-77-9

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 77 In-stock
Solution
10 mM * 1 mL in Water USD 77 In-stock
Solid
5 mg USD 70 In-stock
10 mg USD 120 In-stock
25 mg USD 240 In-stock
50 mg USD 390 In-stock
100 mg USD 630 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC50 of 27 nM.

IC50 & Target

IC50: 27 nM (PPARβ/δ)[1]

In Vitro

DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC50 of 27 nM. DG172 enhances transcriptional corepressor recruitment, and down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC50, 9.5 nM)[1]. DG172 (1 µM) promotes the differentiation of dendritic cells (DCs) from GM-CSF-induced mouse bone marrow cells (BMCs) and reduces Ly6b+/Gr1+ granulocytic cells. DG172 has effects on the transcriptome of GM-CSF differentiated BMCs from WT and Ppard null mice, and acts at a specific stage of GM-CSF-induced differentiation[2]. DG172 (0.1, 1.0 µM) dose-dependently promotes proliferation of TM4 cells. DG172 reduces expression of claudin-11 in TM4 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

455.22

Formula

C20H22BrCl2N3

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

BrC(C=CC=C1)=C1/C(C#N)=C/C(C=C2)=CC=C2N3CCN(C)CC3.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 14.29 mg/mL (31.39 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1967 mL 10.9837 mL 21.9674 mL
5 mM 0.4393 mL 2.1967 mL 4.3935 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
Cell Assay
[3]

The xCELLigence system is used for determining the changes in real time cell proliferation in response to activation of PPARD with an agonist (GW0742) or an inverse agonist (DG172) or the effect of inhibiting ERK signaling in TM4 cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.1967 mL 10.9837 mL 21.9674 mL 54.9185 mL
5 mM 0.4393 mL 2.1967 mL 4.3935 mL 10.9837 mL
10 mM 0.2197 mL 1.0984 mL 2.1967 mL 5.4919 mL
15 mM 0.1464 mL 0.7322 mL 1.4645 mL 3.6612 mL
20 mM 0.1098 mL 0.5492 mL 1.0984 mL 2.7459 mL
25 mM 0.0879 mL 0.4393 mL 0.8787 mL 2.1967 mL
30 mM 0.0732 mL 0.3661 mL 0.7322 mL 1.8306 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
DG172 dihydrochloride
Cat. No.:
HY-19737A
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