2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Midaglizole hydrochloride

Midaglizole hydrochloride  (Synonyms: (±)-DG5128; DG5128)

Cat. No.: HY-U00165 Purity: 99.67%
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Midaglizole hydrochloride (DG5128) is a preferential α2-adrenoceptor antagonist. Midaglizole hydrochloride (DG5128) exhibits 7.4 times higher affinity (pKi=6.28) toward α2-adrenoceptor than α1-adrenoceptor.

For research use only. We do not sell to patients.

Midaglizole hydrochloride Chemical Structure

Midaglizole hydrochloride Chemical Structure

CAS No. : 79689-25-1

Size Price Stock Quantity
5 mg USD 440 In-stock
10 mg USD 704 In-stock
25 mg USD 1424 In-stock
50 mg USD 2280 In-stock
100 mg USD 3640 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Midaglizole hydrochloride:

Midaglizole hydrochloride Related Antibodies

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α adrenergic receptor β adrenergic receptor

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Midaglizole hydrochloride (DG5128) is a preferential α2-adrenoceptor antagonist. Midaglizole hydrochloride (DG5128) exhibits 7.4 times higher affinity (pKi=6.28) toward α2-adrenoceptor than α1-adrenoceptor.

IC50 & Target

α adrenergic receptor

 

In Vitro

Midaglizole (DG-5128) at concentrations up to 10 μM inhibits [3H]clonidine binding more effectively than it doed [3H]prazosin binding in rat cerebral cortex membranes. The mode of inhibition is homogeneous and consistent with the law of simple mass action[1]. The EC50 values for stimulation of insulin release from rat islets and the MIN6 β-cell line induced by Midaglizole are 200 nM and 24 μM, respectively. The IC50 values for KATP current inhibition induced by Midaglizole are 3.8 μM and 4.4 uM for Kir6.2 and Kir6.2/SUR1 , respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Midaglizole hydrochloride Related Antibodies
In Vivo

Midaglizole (3 and 30 mg/kg, i.v.) increases blood pressure in pithed rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

324.25

Formula

C16H19Cl2N3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C(C1=CC=CC=C1)(C2=CC=CC=N2)CC3=NCCN3.[2 HCl]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 500 mg/mL (1542.02 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0840 mL 15.4202 mL 30.8404 mL
5 mM 0.6168 mL 3.0840 mL 6.1681 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Animal Administration
[3]

Rats[3]
Male Wistar rats (290-450 g) are anesthetized with pentobarbital sodium (35 mg/kg, i.p.) and artificially ventilated with room air. Diastolic blood pressure before the administration of the Midaglizole (Midaglizole) is about 35 mmHg. Midaglizole at doses of 3 and 30 mg/kg produces an increase in blood pressure by 27 and 64 mmHg, respectively, at approximately 1 min after the administration.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0840 mL 15.4202 mL 30.8404 mL 77.1010 mL
5 mM 0.6168 mL 3.0840 mL 6.1681 mL 15.4202 mL
10 mM 0.3084 mL 1.5420 mL 3.0840 mL 7.7101 mL
15 mM 0.2056 mL 1.0280 mL 2.0560 mL 5.1401 mL
20 mM 0.1542 mL 0.7710 mL 1.5420 mL 3.8551 mL
25 mM 0.1234 mL 0.6168 mL 1.2336 mL 3.0840 mL
30 mM 0.1028 mL 0.5140 mL 1.0280 mL 2.5700 mL
40 mM 0.0771 mL 0.3855 mL 0.7710 mL 1.9275 mL
50 mM 0.0617 mL 0.3084 mL 0.6168 mL 1.5420 mL
60 mM 0.0514 mL 0.2570 mL 0.5140 mL 1.2850 mL
80 mM 0.0386 mL 0.1928 mL 0.3855 mL 0.9638 mL
100 mM 0.0308 mL 0.1542 mL 0.3084 mL 0.7710 mL
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Midaglizole hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Midaglizole79689-25-1(±)-DG5128 DG5128DG5128DG 5128DG-5128Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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