DHMEQ racemate (Synonyms: rel-DHMEQ)

Cat. No.: HY-14645B: FAQs
Data Sheet Handling Instructions

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DHMEQ racemate is a NF-κB inhibitor. DHMEQ racemate is less active than (-)-DHMEQ.

For research use only. We do not sell to patients.

DHMEQ racemate Chemical Structure

CAS No. : 287194-38-1

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Other Forms of DHMEQ racemate:

(-)-DHMEQ In-stock
(+)-DHMEQ In-stock

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•Related Small Molecules:

•Related Proteins:

View All NF-κB Isoform Specific Products:

View All Isoforms

NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

Biological Activity
Purity & Documentation
References
Customer Review

Description

DHMEQ racemate is a NF-κB inhibitor. DHMEQ racemate is less active than (-)-DHMEQ.

IC₅₀ & Target^[1]

NF-κB

In Vitro

DHMEQ racemate (DHM3EQ) and (-)-DHMEQ (DHM2EQ) inhibits TNF-a-induced NF-kB activation. (-)-DHMEQ is more potent and less toxic than DHMEQ racemate^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The antiarthritic effects of (-)-DHMEQ (DHM2EQ) and DHMEQ racemate (DHM3EQ) are examined on type-II collagen-induced arthritis in DBA1/J mice. This animal model is widely used for evaluation of antirheumatic drugs because of its pathological similarities to human rheumatoid arthritis. The arthritis is elicited and scored. (-)-DHMEQ markedly inhibits type-II-collagen-induced arthritis in mice, whereas DHMEQ racemate tends to only slightly inhibit it^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

522.47

Formula

C₁₃H₁₁NO₅

CAS No.

287194-38-1

SMILES

O=C1[C@H]2[C@H](O2)[C@H](O)C(NC(C3=C(O)C=CC=C3)=O)=C1.O=C4[C@@H](O5)[C@@H]5[C@@H](O)C(NC(C6=C(O)C=CC=C6)=O)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : ≥ 32 mg/mL (61.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9140 mL	9.5699 mL	19.1399 mL
5 mM	0.3828 mL	1.9140 mL	3.8280 mL
10 mM	0.1914 mL	0.9570 mL	1.9140 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Matsumoto N, et al. Synthesis of NF-kappaB activation inhibitors derived from epoxyquinomicin C. Bioorg Med Chem Lett. 2000 May 1;10(9):865-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9140 mL	9.5699 mL	19.1399 mL	47.8496 mL
	5 mM	0.3828 mL	1.9140 mL	3.8280 mL	9.5699 mL
	10 mM	0.1914 mL	0.9570 mL	1.9140 mL	4.7850 mL
	15 mM	0.1276 mL	0.6380 mL	1.2760 mL	3.1900 mL
	20 mM	0.0957 mL	0.4785 mL	0.9570 mL	2.3925 mL
	25 mM	0.0766 mL	0.3828 mL	0.7656 mL	1.9140 mL
	30 mM	0.0638 mL	0.3190 mL	0.6380 mL	1.5950 mL
	40 mM	0.0478 mL	0.2392 mL	0.4785 mL	1.1962 mL
	50 mM	0.0383 mL	0.1914 mL	0.3828 mL	0.9570 mL
	60 mM	0.0319 mL	0.1595 mL	0.3190 mL	0.7975 mL

DHMEQ racemate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHMEQ287194-38-1rel-DHMEQNF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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