1. Autophagy
  2. Autophagy

DMXAA (Synonyms: ASA-404; Vadimezan)

Cat. No.: HY-10964 Purity: 99.19%
Handling Instructions

DMXAA is a competitive inhibitor of the enzyme DT-diaphorase (NAD(P)H:Quinone oxidoreductase EC with respect to NADH, with Ki values of 20 μM.

For research use only. We do not sell to patients.
DMXAA Chemical Structure

DMXAA Chemical Structure

CAS No. : 117570-53-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 106 In-stock
5 mg USD 96 In-stock
10 mg USD 132 In-stock
50 mg USD 528 In-stock
100 mg USD 840 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

    DMXAA purchased from MCE. Usage Cited in: Gastroenterology. 2018 Feb 6. pii: S0016-5085(18)30156-2.

    Expression of IRF3, p-IRF3, p65 and p-p65 in whole pancreatic extract of acute pancreatitis (AP) mice shown by western blot.
    • Biological Activity

    • Protocol

    • Technical Information

    • Purity & Documentation

    • References


    DMXAA is a competitive inhibitor of the enzyme DT-diaphorase (NAD(P)H:Quinone oxidoreductase EC with respect to NADH, with Ki values of 20 μM. [1] IC50 value: 20 μM (Ki) [1] Target: DT-diaphorase in vitro: DMXAA partially inhibits cytochrome b5 reductase activity. [1] DMXAA is a potent tumor blood vessel-disrupting agent and cytokine inducer used for the treatment of non-small cell lung cancer (NSCLC) and other cancers. DMXAA significantly induces G1 phase arrest in A549 cells. DMXAA induces apoptosis via a mitochondria-dependent pathway and promoted autophagy, as indicated by the increased level of cytosolic cytochrome c, activation of caspase 3, and enhances expression of beclin 1 and microtubule-associated protein 1A/1B-light chain 3 (LC3-II) in A549 cells. [2] in vivo: DMXAA has been shown to potentiate the antitumour activity of several bioreductive drugs in vivo. [1] In contrast, treatment with DMXAA results in a significant lower amount in the tumours when compared to the control mice.[3]

    Clinical Trial
    Molecular Weight




    CAS No.




    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    DMSO: 6.5 mg/mL

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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