Network Version
Flavopiridol Data Sheet
| Product Name: | Flavopiridol |
 |
|---|---|---|
| CAS No.: | 146426-40-6 | |
| Cat. No.: | HY-10005 | |
| MWt: | 401.84 | |
| Formula: | C21H20ClNO5 | |
| Purity : | >98% | |
| Solubility: | DMSO : 33.33 mg/mL (82.94 mM; Need ultrasonic) | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
|
Flavopiridol (Alvocidib) is a broad spectrum and competitive inhibitor of CDKs, inhibiting CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively.
IC50 & Target: IC50: 30 nM (CDK1), 170 nM (CDK2), 100 nM (CDK4)[3]
In Vitro: Flavopiridol (2 μM) robustly induces a distinct pattern of ER stress in CLL cells that contributes to cell death through IRE1-mediated activation of ASK1 and possibly downstream caspases[1]. Flavopiridol results in potent upregulation of a number of PRGs in treatments lasting 4-24 h. Flavopiridol has and immediate and long-term effect on the expression of several PRGs. In serum starved cells re-stimulated with serum, flavopiridol also inhibits the expression of these genes, but subsequently, JUNB, GADD45B and EGR1 are upregulated in the presence of flavopiridol[2]. Flavopiridol (Alvocidib) also inhibits cyclin E1 and induces apoptosis[4]. |
||
1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] Web:www.medchemexpress.com