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Telotristat etiprate Data Sheet
| Product Name: | Telotristat etiprate |
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|---|---|---|
| CAS No.: | 1137608-69-5 | |
| Cat. No.: | HY-13055 | |
| MWt: | 754.15 | |
| Formula: | C36H35ClF3N7O6 | |
| Purity : | >98% | |
| Solubility: | DMSO : ≥ 28 mg/mL (37.13 mM) | |
| Mechanisms: | Target: Cancer Neurological Disease | |
| Biological Activity: | ||
| Telotristat etiprate (LX1606 Hippurate) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production. In Vivo: Telotristat ethyl (15, 50, 150, 300 mg/kg, po, qd) reduces serotonin content in the periphery, but not in the brain of the mice. Telotristat ethyl (200 mg/kg po, qd) prevents the increase in blood neutrophil counts that is observed after TNBS challenge, provides significant protection in a mouse model of inflammatory bowel disease. Telotristat ethyl (200 mg/kg po, qd) protects the mouse IBD model confirmed by histopathology evaluation[1]. Telotristat ethyl (15, 50, 150, 300 mg/kg) depletes 5-HT from the jejunum but not the brain. But Telotristat ethyl (200 mg/kg, p.o.) does not deplete enteric neuronal serotonin (5-HT), or alter constitutive gastrointestinal motility in mice. Telotristat ethyl (200 mg/kg) alleviates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis[2]. | ||
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